6EZ8


Conserved Protein Domain Family
DUF3652

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pfam12372: DUF3652 
Huntingtin protein region
This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with pfam02985. This family is in the middle region of the Huntingtin protein associated with Huntington's disease. The protein is of unknown function, however it is known that a polyglutamine (CAG) repeat in the gene coding for it results in the development of Huntington's disease.
Statistics
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PSSM-Id: 403547
View PSSM: pfam12372
Aligned: 11 rows
Threshold Bit Score: 50.1377
Threshold Setting Gi: 968074385
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6EZ8_A       1509 QIIGIPKIIqlcDGIMASGRKAVTHAIPAL-----QPIVHDLF 1546
EFA10047     1236 SIITVPKIIhlcDGLMASEQSPLTHCIPAL-----EPIVENIF 1273 red flour beetle
XP_002070517 2706 ALLQHPRIW---REVNASTT-GVRSELLEVltmtgRCLLQDTI 2744 Drosophila willistoni
EDW38895     2793 ALLQQPRVW---RDLNASTDAALRCELLEVlchsaRCMLQETI 2832 Drosophila persimilis
EDX14747     3353 ALLQQPRVW---RELNASLNPSLRCELLDLldsvaRCILQDTI 3392 Drosophila simulans
EFN65477     1290 AIIGIPKIIqlcDGLMASGQPAITHCIPAL-----APVIEDIF 1327 Florida carpenter ant
NP_077333    1494 QIIGIPKIIqlcDGIMASGRKAVTHAIPAL-----QPIVHDLF 1531 Norway rat
XP_002114774  963 PIVGIPRILqlsDGIMASGQLAPAHVIPAF-----RPVVFDLF 1000 Trichoplax adhaerens
EKC42935     1371 SIIGMPKIIqlcDGIMASGLQPVSHAIPAL-----RPVVFDLF 1408 Pacific oyster
XP_001955065 2713 ALLLQPRVW---RDLNARLDPGPRCDLLELldrvsGCILQDTI 2752 Drosophila ananassae
NP_001342356 1323 AVITMPKIIqlcDGLMASGQGSASHVIPAM-----QPIIHDIY 1360 vase tunicate
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