4AY9


Conserved Protein Domain Family
GnHR_trans

?
pfam12369: GnHR_trans 
Gonadotropin hormone receptor transmembrane region
This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with pfam00560, pfam00001. There are two completely conserved C residues that may be functionally important. This family contains the transmembrane region of Follicular stimulating hormone and leutenizing hormone - the two major gonadotropin hormone receptors. These receptors are G protein coupled receptors involved in development and maturation of germ cells in both fecund genders. The transmembrane region is conserved between the two different receptors while the extracellular ligand binding domains are less well conserved.
Statistics
?
PSSM-Id: 403546
View PSSM: pfam12369
Aligned: 9 rows
Threshold Bit Score: 75.9894
Threshold Setting Gi: 542199532
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
4AY9_X       266 RRQISELHPI-------CNKSILRQEVDYMTQARGq-RSSL--------AeDNESSysrGFDMTYTEFDX---DLCNEVV 326
EGW01217      75 RRQISELHPI-------CNKSILRQDIDDLTQARDr-NTSL--------I-DDEPGygkESDMMYSEFDY---DLCNEVV 134 Chinese hamster
XP_023367869 256 RRQISELHPI-------CNKSILRQEFDDMTQARGq-RVSL--------AeDDESSyskGFDMLYNEFDY---DLCNEVV 316 small-eared galago
XP_003758338 282 RRQAFELHPI-------CNKSFVRQDSNDLAMEWGyrRRSM--------EeEYISSlnkEFDITESEFDY---DLCNEVV 343 Tasmanian devil
XP_001375482 288 RRQAFELHPI-------CNKSSVRQDGDDLAMDQGhgRRSV--------EeEFVSSldkGFEITETEFDY---DLCNEVV 349 gray short-tail...
XP_021336225 258 NSRDGSVNSAlrnrssyCGDNSSPADLSAISS-----DDPL--------EsDVIGSssvEDTFGSIDFHYpdlDLCQQRQ 324 zebrafish
P79763       282 KTQNTEFYPI-------CSMSPAKQDLGEQTGKRKh-RRSA--------AeDYISHygtRFGPVENEFDY---GLCNEVV 342 chicken
EOB06810     282 KRQNTELHPI-------CSISQAKQDLDEQPGNKIh-RRSA--------AeDYISNyaiGFDPSENEFDY---GLCNEVV 342 mallard
XP_005474059 288 THRDLSINPVwnnsstsCIERDPAGRVQPVIGGST--DTSLlmgvqyfsEgDLLAE---DEPYGDVNFHYpelDLCQTTR 362 Nile tilapia
4AY9_X       327 DVTCSPK 333
EGW01217     135 DVTCSPK 141 Chinese hamster
XP_023367869 317 DVTCFPK 323 small-eared galago
XP_003758338 344 DVACSPK 350 Tasmanian devil
XP_001375482 350 DVACFPK 356 gray short-tailed opossum
XP_021336225 325 ALQCSPE 331 zebrafish
P79763       343 DFVCSPK 349 chicken
EOB06810     343 NVACSPK 349 mallard
XP_005474059 363 TLVCTPE 369 Nile tilapia
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap