Conserved Protein Domain Family
CTK3_C

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pfam12350: CTK3_C 
CTD kinase subunit gamma CTK3 C-terminus
The C-terminal domain kinase (CTDK-1), is a three-subunit complex comprised of Ctk1, Ctk2, and Ctk3, that plays a key role in regulation of transcription and translation and in coordinating these two processes. Both Ctk2 and Ctk3 are regulated at the level of protein turnover, and are unstable proteins processed through a ubiquitin-proteasome pathway. Their physical interaction is required to protect both subunits from degradation, and both Ctk2 and Ctk3 are required for Ctk1 CTD kinase activation. The mammalian P-TEFb is mirrored by the combined complexes in yeast of the CTDK1 and the Bur1/2. It is not clear what independent function this C-terminal domain has.
Statistics
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PSSM-Id: 403534
View PSSM: pfam12350
Aligned: 61 rows
Threshold Bit Score: 60.7242
Threshold Setting Gi: 525582013
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WGS:AACS:CC1G_04629 200 SKNDVFKRIEEDRERHKRLRERRWVQPISYasssFnpkhmplasflpltttsktsagqdqaapefpeeelpvDIEFENEW 279 Coprinop...
XP_011272742        197 TKDQILMRIEADRERHKRFKEVNWIVNRPSgk--------------------------------------veMKEFEKIW 238 Wickerha...
XP_001645628        236 STQITLHRMESDRERHKRAKEHMWFINKTNml---------------------------------------dESEFQNLW 276 Vanderwa...
Q6CSE1              278 qlQTLLHRMENDRERHKKSKEHEWVIDRATmt---------------------------------------dTLEFDTVW 318 Kluyvero...
Q75E03              242 SASTILHRMESDRERHKKSKEHLWFTDRDSsm--------------------------------------leLAEFDALW 283 Eremothe...
EJT44594            223 nANILLHRMEADRELHKRSKETSWCVERPS----Ndi---------------------------------ldESEFQTLW 265 Saccharo...
Q6FP45              277 nvSNILHRMENDRERHKRQKENNWVVERVS----Qsm---------------------------------ldENEFKAAW 319 [Candida...
XP_003674495        226 ltTTILHRMENDRERHKRMKEQRWIIERGNqlnkKti---------------------------------ldEQEFKLLW 272 Naumovoz...
CAR29661            203 STQTIIHRMESDREKHKRLKENIWVLPRPH----Asi---------------------------------lnEFEFRTLW 245 Zygosacc...
CCE90191            217 SSSTILHRMENDREKHKRLKENNWVLERPS----Isi---------------------------------vdPQEFRSMW 259 Torulasp...
WGS:AACS:CC1G_04629 280 ETTSDWNEDDEEVVAEEREL 299 Coprinopsis cinerea okayama7#130
XP_011272742        239 NQYGELAEG----DYQDLKE 254 Wickerhamomyces ciferrii
XP_001645628        277 NKIP---NSLTAEDLTSIQE 293 Vanderwaltozyma polyspora DSM 70294
Q6CSE1              319 NSYA---LGMNRNDYQNIKT 335 Kluyveromyces lactis
Q75E03              284 QQHR---KGMTRDDYQDVKQ 300 Eremothecium gossypii
EJT44594            266 THFETTDSGFDKDDYKNIKA 285 Saccharomyces kudriavzevii IFO 1802
Q6FP45              320 NSITSL-PSLSRSDQKDIRQ 338 [Candida] glabrata
XP_003674495        273 ENQDN--NTLTTDDIKNVKE 290 Naumovozyma castellii CBS 4309
CAR29661            246 ESTPQ--EGLTKGDYRNMSD 263 Zygosaccharomyces rouxii
CCE90191            260 ENEPY--NTLTKQDYKNIKD 277 Torulaspora delbrueckii
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