5OGS


Conserved Protein Domain Family
Mcl1_mid

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pfam12341: Mcl1_mid 
Minichromosome loss protein, Mcl1, middle region
Mcl1_mid, or the middle domain of minichromosome loss protein 1, is the domain that lies between a 7-bladed beta-propeller at the N-terminus, family WD40 pfam00400 etc, and a Homeobox (HMG) domain, pfam00505, at the C-terminus. The full length proteins with all three domains are referred to as DNA polymerase alpha accessory factor Mcl1, but the exact function of this domain is not known.
Statistics
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PSSM-Id: 403527
View PSSM: pfam12341
Aligned: 114 rows
Threshold Bit Score: 196.242
Threshold Setting Gi: 74843038
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5OGS_A            108 PFQSGSTp-----------lHlT-HRFMVWNSIGIIRCY-NDEQd-----NAIDVEFHDTSIH-HATHLS-NTLNYTIAD 167 
KRH54759          424 PFQPGSTpvq-----------pgkRRFLCYNMLGCITS----IEhd--gySHIEIDFHDTGST-PRVPSMtDHFGFTMAA 485  soybean
XP_002317959      425 AFQPGATppq-----------rgkRRFLCYNMLGTITA----VEnd--gySHIEIDFHDTGRG-PRLPSMtDYFGFTMAS 486  black cot...
JCVI:AT3G42660.1  432 SFQPGATppe-----------pgkRTFLCYNMLGCITT----IEhe--gnSRIETDFHDTGRG-PRVSSMiDIYGFTMAS 493  thale cress
EFN52732          412 AIQPGATe-----------mGdSgRRYLAFTGLGCIMLRqEEDH------NVVEVSFHDSSRQrKRIPLLnDFFGFSLGS 474  Chlorella...
jgi:OSTLU_539     338 AFQSGSVaavp----------gsnRRFLSYTMVGSITS----TVeg--gfNSVEFQFHDTSRM-GRIPTItDYNGYTMGV 400  Ostreococ...
XP_003063981      407 PFQVGACdaakkp--kdgekEn--RRFLCYNMMGTVVT----TGepggdfNSVEMSFHDTSRA-GRAPTItDYHGYSIGT 477  Micromona...
jgi:MICPUN_62102  431 PFQVGSVpaktakddagndaNgStRRFLCYNMIGSVVS----TGepggdfNSVEMAFHDTSRG-GRIPTItDYHGYSVGC 505  Micromona...
EEC44446          593 AFGPSSTsle------------ltRRFLCWNHIGSVTFL---RGqaginrSTIDIHFTDSAFR-RPVSFT-DNMGFILGS 655  Phaeodact...
XP_009412221      424 AFQPGSTpae-----------tgkRCFLVYNMLGSITT----IEnd--gySHVEVDFHDTGRG-PRVPAMtDYFGFTMAA 485  wild Mala...
5OGS_A            168 LSHEAILLAcest----------------------------------delaSKLHCLHFSSWDS--SKEWIIDLPQNEDI 211 
KRH54759          486 LNESGSIFAnpckg---------------------------------ennmSTLMYRPFSSWAN--NSEWSMRFEG-EEV 529  soybean
XP_002317959      487 LNENGSVFAnpckg---------------------------------eknmSTLMYRPFSSWAN--NSEWSMRFEG-EEV 530  black cot...
JCVI:AT3G42660.1  494 INETGCVFAnpckg---------------------------------eknmSVLMYRPFRSWAS--NSEWTMRFEG-EEV 537  thale cress
EFN52732          475 LGDKGALYAsrsn----------------------------------sesaSTVVYRPFEAWAP--NSDWSLSLPKGEEA 518  Chlorella...
jgi:OSTLU_539     401 AGEKGCALAspmkd---------------------------------seneSVLYFQQYDNWAN--DGEWQVTMPAGEDI 445  Ostreococ...
XP_003063981      478 LGEKGCALAspgkp---------------------------------gggaSTVFYRPYESWAH--ASEWRVTIPAGEDA 522  Micromona...
jgi:MICPUN_62102  506 LGERGCALAspakq---------------------------------sggsSVLFYRPYESWTH--KSDWSVTLPVGEDV 550  Micromona...
EEC44446          656 LGEDGGIFAtdlaededideedddmdglnvsaatkaavkrsrkgpsnkptgSSIYFHRFETFGSlrDKDWYLTLPDGERA 735  Phaeodact...
XP_009412221      486 LNENGSVFSnpckg---------------------------------eknmSTLMYRPFSSWAN--NSEWLMRFEG-EEV 529  wild Mala...
5OGS_A            212 EAICLGQGWAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYhrgt-----gfdgDQCL------GVQLL 280 
KRH54759          530 KVVALGSAWVAAVTSFNYLRIFSEGGLQRDVFSLDGPVVTASGFKDKLAVVThatdg----llsndQKL------EFMVF 599  soybean
XP_002317959      531 KVVALGTAWVAAITSLNFLRIYTDGGLQRHILSLDGPVVTASGLKNQLAVVThvsdc----lpsndQML------EFRVF 600  black cot...
JCVI:AT3G42660.1  538 KVVANGSGWVAAVTSLNLLRVFSEGGLQKHILSLDGPVVTAVGCKDHLAVVThvsdc----lpsneQVM------EFRVF 607  thale cress
EFN52732          519 ECAAAGGSFCAVATSKRHLRLFSQAGTQTHLLTLPGAPVGLAAAGHQLAAVWhgaap----taggDQCL------QYALY 588  Chlorella...
jgi:OSTLU_539     446 LSIATGSTWVAAVTSKRYLRIYSLGGAQRQIISLEGDAVSISGSDDALAVVWheaapi--gpapgSQVL------AYAVY 517  Ostreococ...
XP_003063981      523 VSVAAGNNWVAAVTSKRNLRLFSHAGAQRQIVTLEGAPVTCVGKGDSLVVTWhaaapa-lvpgadGR-LeveqriEFAEY 600  Micromona...
jgi:MICPUN_62102  551 VSVATGKDWVAALTSGRMLRVFSHAGAQRQMVQLDGAPVTAAGKGDSLVVAWhasapalvpdaadPKVLrvepriEFAEY 630  Micromona...
EEC44446          736 LGCASGEGWAAVVTSRRFLRLFSSGGNQGEVLWLNGHPVTMAGRGRFVAVVYhestp----lpdgTQKL------GYLVL 805  Phaeodact...
XP_009412221      530 KAVALGTGWVAAITNLNLLRIFTEGGLQRHILCLNGPVVTAAGYEDKLAIVThasec----lssgdQML------DVLVL 599  wild Mala...
5OGS_A            281 ELgkk-kkQilHGDPLP-LTrkSYLAWIGFSAEg--TPCYVDSEGIVRMLNr----------gLGNtWTPICNTREhCK- 345 
KRH54759          600 NIprg-tlL--LQGRLP-LSpgSSLSWFGFSEEg--QLCSYDSKGVLRSYTskf----------ggrWIPLFSATK-EKs 662  soybean
XP_002317959      601 DIsng-tqP--LTGRLP-LTpgSHLTWFGFSEEg--QLSSYDSKGVLRVFTsqy----------ggnWLPIFSARK-EKk 663  black cot...
JCVI:AT3G42660.1  608 NIskm-tqE--LKGRVA-LTpgSRLTWIGFSEEg--SLSSYDSEGVLRVFTsqy----------ggsWIPVFSTSK-EKk 670  thale cress
EFN52732          589 DVaeq-rqV--HGGPLP-LSpaASLAWLGFAEEg--LLAAYDTEGELRLRSadf----------ggsWVTAFSAAAeRKs 652  Chlorella...
jgi:OSTLU_539     518 NVrys-seL--ARGRVA-LStqSTLTYLGFSEEg--MLVTRDSAGVVRMRTdaf----------ggsWTPVFRSSS-ARa 580  Ostreococ...
XP_003063981      601 DVadggkiL--SRGRVP-VPpgHTLTWLGHSEDdnrALCFGASDGTVRVRVpdf----------ggsWSQVFSSMD-ARq 666  Micromona...
jgi:MICPUN_62102  631 DVasggkvL--SKGRIP-LPpgATLTWLGHVEDgngAIAFGASDGCVRVRTsef----------ggsWTPVFRSQD-ARq 696  Micromona...
EEC44446          806 DAman-rvV--AKGPVScISgaSTLSWLGFSNDg--SLLAMDSDGMLSMLVcassldaegpteKHWeWMPMLDTVG-LRk 879  Phaeodact...
XP_009412221      600 NIseg-akL--FEGRLP-LSptSCLTWFGFSEEg--QLSSYDSKGVLRVFShqy----------ggsWLPVFSAEK-TRk 662  wild Mala...
5OGS_A            346 GKSDhYWVVGIHEn-----pQQLRCIPCKGs---rFPPTlPRPAVAILS 386 
KRH54759          663 --DEnYWVTGLNA-------SKVFCVVCKKpe--dFPQVmPKPVLTPLN 700  soybean
XP_002317959      664 S-DEsYWVVGLNA-------SKLFCIVYKDpd--mFPQViPKPVLSLLN 702  black cottonwood
JCVI:AT3G42660.1  671 Q-EEnYWVVGLNT-------SSLYCIACKYae--mFPQVtPKPILTILD 709  thale cress
EFN52732          653 --TEqYWVVGLGA-------KELQCIVCANttepaVPSGmQRPVVTAVA 692  Chlorella variabilis
jgi:OSTLU_539     581 TDGQhHWIVSSCA-------STLYCIITRTsa---gPVPnPRPVLSMLP 619  Ostreococcus lucimarinus CCE9901
XP_003063981      667 SEGEhHWVVAVATsdnayssSALYCVVCRDas---gPGVyPKPVQTLMP 712  Micromonas pusilla CCMP1545
jgi:MICPUN_62102  697 QEGEhHWTVAVSVa-----eSALYCVVGGNan---gPAVhPRPVLTPLP 737  Micromonas commoda
EEC44446          880 SRDDsFWPVTVYD-------GKLVCVPLKGgm--kHPDAvRRPVTAALG 919  Phaeodactylum tricornutum CCAP 1055/1
XP_009412221      663 SEDEtYWIVGLNA-------SKLFCIICKSpn--cYPTVmPKPVLELLS 702  wild Malaysian banana
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