Conserved Protein Domain Family
Dsh_C

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pfam12316: Dsh_C 
Segment polarity protein dishevelled (Dsh) C terminal
This domain family is found in eukaryotes, and is typically between 177 and 207 amino acids in length. The family is found in association with pfam00778, pfam02377, pfam00610, pfam00595. The segment polarity gene dishevelled (dsh) is required for pattern formation of the embryonic segments. It is involved in the determination of body organisation through the Wingless pathway (analogous to the Wnt-1 pathway).
Statistics
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PSSM-Id: 403510
View PSSM: pfam12316
Aligned: 17 rows
Threshold Bit Score: 87.9464
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003966937 506 YMANLTLNDNDGSS-GASDQDTLAPLPLPGASPWPMmhTFPYQpY-PT-HAFSSQPpPYHELSSYSYAPGSTGSQHSE-- 580 torafugu
XP_015216866 435 NMANLSLHDHDGSS-GASDQDTLAPLPHPGAAPWPL--AFPYQ-Y-PVpHPYNPHP-LHDPAFSYGGGGGSAGSQHSE-- 506 spotted gar
EGV97796     287 NMANLSLHDHDGSS-GASDQDTLAPLPHPGAAPWPM--AFPYQ-YpPPpHPYNPHPgFPE--LGYSYGGGSASSQHSE-- 358 Chinese hamster
Q60838       515 YLVNLSLNDNDGSS-GASDQDTLAPLP--GATPWPLlpTFSYQ-Y-PApHPYSPQPpPYHELSSYTYGGGSASSQHSE-- 587 house mouse
7_pfamImport   1 NMTHLSLHEHDGSSgGASDQDTVPPLPHPGAAPWPI--TLPYQ-F-PVlHPYDMQQpGHG-----GPGAGSAGSQNSVin 71 
XP_001920242 510 NMASLTLHDHDGSS-GASDQDTLAPLPHPGVAPWPL--AFPYQ-Y-PIpHPYNPHP-VHEPGYSFTAGGGSVGSPHSE-- 581 zebrafish
XP_022521691 513 NMANLTLHDHDGSS-GASDQDTLAPLPHPGAAPWPL--PFPYQ-Y-PIpHPYNPHP-VHEPTYSYTVGGGSAGSPHSE-- 584 Mexican tetra
KAE8620805   360 YMANLSLNDNDGSS-GASDQDTLAPLPLPGASPWPLlpTFSYQ-Y-PApHPYSTQPpAYHELSSYSYGMGSAGSQHSE-- 434 tropical clawed...
XP_023822010 506 yMANLSLNDNDGSS-GASDQDTLAPLPLPGATPWPMmhTFPYQaY-PT-HPYSSQPpPYHELTSYSYAPGSTGSQHSE-- 580 Japanese medaka
XP_012821473 402 NVAALNLNE--GSS-GTSDQDTLAPLPHP-AAPWPLgqGYSYQ-Y-PLaPP--CFPpTYQE-PGFSYGSGSAGSQHSE-- 470 tropical clawed...
XP_003966937 581 ----GSR-SSGSTRSEGDRRRTAKGP---------------------GSTVGggDkspsaggegggadsRSGSGSESEYS 634 torafugu
XP_015216866 507 ----GSR-SSGSNRSGSEQRRKEKEG---------------------AGPAKagGase---------pkSGGSGSESDHT 551 spotted gar
EGV97796     359 ----GSR-SSGSNRSGSDRRKEKDPK---------------------AGDSKs-----------------gGSGSESDHT 395 Chinese hamster
Q60838       588 ----GSR-SSGSTRSDGGAGRTGRPE---------------------ERA----Pe------------sKSGSGSESELS 625 house mouse
7_pfamImport  72 ipsnSSKgSSGSNCSKNEGRKSG------------------------------------------------GSGSEPE-- 101
XP_001920242 582 ----GSR-SSGSNRSGTKNDTNAAPA---------------------APESGg----------------rSGSGSESD-- 617 zebrafish
XP_022521691 585 ----GSR-SSGSNRSGTK------AG---------------------AVETKs-----------------gGSGSESE-- 613 Mexican tetra
KAE8620805   435 ----GSR-SSGSNRSDG--GRGTQKD---------------------ERSGVvgVggg---------esKSGSGSESEYS 477 tropical clawed...
XP_023822010 581 ----GSR-SSGSTRSEGERHRGSKGPgsvvgggeksptggggdggggDSRs--------------------GSGSESEYS 635 Japanese medaka
XP_012821473 471 ----GSK-SSGSSRSNRE-GKRSSGR---------------------EKDRRs-----------------tGSGSGSDRA 506 tropical clawed...
XP_003966937 635 TRSSLr-RGHGSAAPSEHSHASSQRSHHHRmappphlspyppgiLPYNpmmvmmvpQHPhpam----------------- 696 torafugu
XP_015216866 552 TRSTT--VRRERAPSERSAAPPSEHSVRSGhs-----------lRSSH--------SHA--------------------- 589 spotted gar
EGV97796     396 TRSSl-rGPRERAPSERSGPAASEHSHRSHhs----------ltSSLR--------SHHth------------------- 437 Chinese hamster
Q60838       626 SRGGSlrRGGEPGGTGDGGPPPSRGSTGAppnlra---------------lpglhpYGApsgm----------------- 673 house mouse
7_pfamImport 102 -------IRSHRAPSERSAAPPSERSVRSSv------------sHRSAh-------SHSiafg----------------p 139
XP_001920242 618 --------RREKAPSECSAAPPSEHSVRSSht-----------iRSIH--------SHTsn------------------- 651 zebrafish
XP_022521691 614 --------KKDKAPSERSAAPPSEHSVRS---------------------------THSvhsihsvrsvhsvhsvqshgq 658 Mexican tetra
KAE8620805   478 TRSSIr-R-----IGGGEAGPPSERSTSSrpplhh----------------ppsvhSYAapgv----------------- 518 tropical clawed...
XP_023822010 636 TRSSLr-RGHGSAAPSEHSHA-SSRSHHH-----------------HHhrlpqpphMSPyppg----------------- 679 Japanese medaka
XP_012821473 507 PRSGGskNERPLSQHSHHSHSSVSRSQRShrss----------------------------------------------- 539 tropical clawed...
XP_003966937 697 aaaHtlphpqqMP---------------------------------TAMHPAlAPPp-----sSTPGGPPGAPP-TRDLG 737 torafugu
XP_015216866 590 ---Y-------GP---------------------------------PGLPPP-SFPqppmglmGSSAAPPGAPP-SRDLG 624 spotted gar
EGV97796     438 -psY-------GP---------------------------------PGVPPLyGPPmlmmtppPAAMGPPGAPP-GRDLA 475 Chinese hamster
Q60838       674 alpY-------NPmmvv--------------------------mmpPPPPPV-----------STAVQPPGAPP-VRDLG 708 house mouse
7_pfamImport 140 glvY-------GP---------------------------------PGLPPQ--PP--------LSTAAPGAPP-GRELA 168
XP_001920242 652 -mvC-------GA---------------------------------AGLPPQ--PP---------VAAAPGSPP-EQDLS 678 zebrafish
XP_022521691 659 nlvY-------GP---------------------------------PGLPPQ--LP--------TVAAAPGSPP-GRDLA 687 Mexican tetra
KAE8620805   519 plsY-------NPmmlm-------------------------mmppPPLPPPgACP-------PSSSVPPGAPPlVRDLA 559 tropical clawed...
XP_023822010 680 ilpY-------NPmmvmmvpqhphhpalaaahglphtqqlppapmhPALPP----Pp-----sSTPGGPPGAPP-TRDLG 742 Japanese medaka
XP_012821473 540 hhsH-------GP---------------------------------PGLPPLfSLPkignkvyGTS-GPPGGPP-VRELA 577 tropical clawed...
XP_003966937 738 SVPPELTASRQSFHLAMG 755 torafugu
XP_015216866 625 SVPPELTASRQSFRMAMG 642 spotted gar
EGV97796     476 SVPPELTASRQSFRMAMG 493 Chinese hamster
Q60838       709 SVPPELTASRQSFHMAMG 726 house mouse
7_pfamImport 169 SVPPELTASRQSLRMAVG 186
XP_001920242 679 SVPPELTASRQSFRMAMG 696 zebrafish
XP_022521691 688 SVPPELTASRQSFRMAMG 705 Mexican tetra
KAE8620805   560 SVPPELTASRQSFHMAMG 577 tropical clawed frog
XP_023822010 743 SVPPELTASRQSFHLAMG 760 Japanese medaka
XP_012821473 578 NVPPELTGSRQSFQKAMG 595 tropical clawed frog
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