Conserved Protein Domain Family
Elf-1_N

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pfam12310: Elf-1_N 
Transcription factor protein N terminal
This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with pfam00178. There is a conserved PAVIVE sequence motif. Elf-1 is an immune cell specific transcription factor. It is found in T cells, B cells, megakaryocytes,and mast cells and is involved in the control of transcription for various immune proteins. These include IL-2, GM-CSF, IL-5, IL-2 receptor alpha chain, and CD4 in T cells, IgH, blk, and lyn in B cells, TdT in T and B cells, IL-3 in megakaryocytes, and SCL and Fc-epsilon-RI alpha chain in mast cells.
Statistics
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PSSM-Id: 403506
View PSSM: pfam12310
Aligned: 16 rows
Threshold Bit Score: 109.478
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005159887   4 VVLVDSGGAVVEYVT-AVDDHLPEEGgVYevegemegevegdvEYPAVIVEPVPSARM---EQGFAAQVLVYDDETYLMQ 79  zebrafish
XP_006639126   2 AAAVQQSELVFEFASnCMEDIQQLND-PS--------------VFPAVIVEQVPSAHL---LQDYSGLA-CAEHSSDVIH 62  spotted gar
XP_006633101   2 TTAVQPTELVFEFASnGMDEIHQLDD-PS--------------VFPAVIVEQVPAADL---MQVYSGLE-SDEVPNGIMA 62  spotted gar
Q3U1U8         2 AIALQPSDLVFEFASnGMDDIHQLED-PS--------------VFPAVIVEQVPYPEL---VHLCSGLD-LDEVHNGIIR 62  house mouse
Q0IHW0         2 ATVVQPNDLVFEFASnVMEDEHQLGD-PS--------------IFPAVIVEHIPNADL---LHSYSGLT-CVDEPNNMIT 62  tropical clawed...
XP_003131046   2 AAVVQQNDLVFEFASnVMEDEQQLGD-PA--------------IFPAVIVEHVPGADI---LNSYAGLA-CVEEPNDMIT 62  pig
1_pfamImport   1 AAVVQQNDLMFEFASnVMEDEQQVGEkPP--------------PIPWIAKLEIPGIDFhwvMNRYTGLNYCVLVYHDVHT 66 
XP_015200291   4 VVVVDGGGPVVEYVS-AMENPQQEEVqGE--------------EYPAVIVEQVPSARL---EQCYAAQVLVYDDETYLMQ 65  spotted gar
XP_031407897   2 AAVVQQNELVFEFASnVMEDEQqLGD-PS--------------IFPAVIVEHVPSGDL---LNNYSGLT-CVDEPSDMIT 62  turkey
XP_029298240   2 tTAVQPSELVFEFASnGMDEINQLDD-PS--------------VFPAVIVEQVPAADL---LQVYSGLE-SDEVTNGIMV 62  Cottoperca gobio
XP_005159887  80 G----VAEEQEV--ETEVLET-VEASVHG--VQCSDKTIEAAEALLHMDSP 121 zebrafish
XP_006639126  63 HssldVAEEQVI--VNEDVTLtVEASCHDggDETME-TIEAAEALLHMDSP 110 spotted gar
XP_006633101  63 DtsldVVEEQIM---GRDLGLaVEAAGQDt-EENME-TIEAAEALLNMESP 108 spotted gar
Q3U1U8        63 DrtlcMTQDQIL--EGSILLTdDDVSTSN--------NVSSTEVLFNVATP 103 house mouse
Q0IHW0        63 EnsldVAEEQIId-DDDDITLtVEASCHNg-DETME-TIEAAEALLNIDSP 110 tropical clawed frog
XP_003131046  63 EssldVAEEEIIdeDDDDITLtVEASCHNg-DETIE-TIEAAEALLNMDSP 111 pig
1_pfamImport  67 HfvyvLNEMNMFdkVDDGFTLtVEASCQNg-DETMQ-TIEAAEALLNMESP 115
XP_015200291  66 D----VAEEQEI--ETEIVES-VEASVHGsnVHCSDKTIEAAEALLHMDSP 109 spotted gar
XP_031407897  63 EnsldVAEEQII--EDDDIPLtglqynffsamllqqdgcg----------- 100 turkey
XP_029298240  63 DttlhIVEEPSI--LVGGVDL-SETSVSGp-EDSME-TNEAAAALLNMESP 108 Cottoperca gobio
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