Conserved Protein Domain Family
Bot1p

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pfam12298: Bot1p 
Eukaryotic mitochondrial regulator protein
This family of proteins is found in eukaryotes. Proteins in this family are typically between 168 and 381 amino acids in length. Bot1p localizes to the mitochondria in live cells and cofractionates with purified mitochondrial ribosomes. Bot1p has a novel function in the control of cell respiration by acting on the mitochondrial protein synthesis machinery. Observations also indicate that in fission yeast, alterations of mitochondrial function are linked to changes in cell cycle and cell morphology control mechanisms.
Statistics
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PSSM-Id: 403498
View PSSM: pfam12298
Aligned: 19 rows
Threshold Bit Score: 169.809
Threshold Setting Gi: 758978671
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6CH22              102 PLVPFPDNPYTRTNTVIPESVREHIIKDVTVNSM--SLEDVSVKYGIQLVRLRALLKLNQVRQTFk-----cDPKYKKDL 174 Yarrowia...
EEQ28823            119 RLQPFPLNPFFVSESVLSEELRNEIYDQVVNKGN--SVRLVSVMFGVDMRRIGAVVRLVELEKRMka----eLKQKKPMA 192 Microspo...
EAW12787             88 SNRPFPLNPNFVSEPILSEELRKEIYRRVVDRKQ--SVRAVSVDLGVDMRRVAAVVRLVELEKRW-------KQQGKSLA 158 Aspergil...
EED51957            100 RTRPFPLNQNFVSESILSEELRNEIYDRVVNQKK--SVRAVSVDLGVDMRRVGAVVRLVELEKRQ-------KQQGKSLA 170 Aspergil...
XP_002147453        106 PKTPFPLNPQFISEPILSEELSNEIYKRVAQQGK--SVRSVSVEMRVDMRRVGAVVRLKELEKRM-------KNEGKSMA 176 Talaromy...
Q0UEV8              121 DLRPFPLNQYFRSQPVLSEDLREAIYQRVKKDGA--TVSLASVEYGVSNERVGAVVRLKQLEKEW-------IAQGKHLA 191 Parastag...
Q2H3W6               90 GSRPFPNNPNFRSEPVLSSEARKMIWEAIMVKGM--PLKAVSAEFHVDMRRVAAVVRMMEIEKKYerevtntCRQGQPLA 167 Chaetomi...
WGS:AATM:SJAG_02067 102 SSAPFPLNPLFHPAKPLSHLLRQKIYEKYSKGD---SLEKLAKEYKTCPQRVEAIVKLARINESW-------GNNGTPVL 171 Schizosa...
O60096              116 TNQPFPLNPFFKPPRPISHSLRMKITDEYLQGA---SIEVLARKFNTSPQRIEALIKLRRINDEF-------EEKKKPIL 185 Schizosa...
XP_011389385        113 GDTPFPLNPSFNPPAPIRQSTKTEIWRLHASDPKewTIRALSEKFSIGLQRTEAILRLKALESEW-------TSKNKPLQ 185 Ustilago...
Q6CH22              175 SKFSSSIVEMLPR----------LRVNYTFKEEddkrekrvyfnkeqgqqNLSEVPVPSATRGSRFMTLAESEPFGPVES 244 Yarrowia...
EEQ28823            193 LPYGRAIRDMLPTtrl------agKGEKQQPHE-----------------PINDLPVHKLTEPQIFYPVSESRNFTRVDA 249 Microspo...
EAW12787            159 LPYARAVHEMVPTtq-------lRSDMDARPHE-----------------SINDLPVHRLTDPQIFYPVSESRQFTRMDA 214 Aspergil...
EED51957            171 LPYARAIHEMVPTtpl----yedTRDNRNRPHE-----------------SINDLPVHKLTDPQIFYPVSESRQFNRVDA 229 Aspergil...
XP_002147453        177 VPYSRAIHEMVPTtpl------aeRGESQPVHE-----------------SINDLPVHRLTAPQIFYPVSESRQFTRVDA 233 Talaromy...
Q0UEV8              192 IPYSKAVLDMLPItpyvdtskpeNRGKRPIIHE-----------------PINDLIVHPATRQQLFVPVSESRHFTRVDA 254 Parastag...
Q2H3W6              168 HAYARAIEKMLPRqd---------lRDGEDKFE-----------------PINDIHVHSHTMQQLFVPTSESREFTRADA 221 Chaetomi...
WGS:AATM:SJAG_02067 172 ESYSRVMEKML------------NACQKREEIQf---------------nDDNDIAV-KTTMVQRWKVLPENEPYTTKDA 223 Schizosa...
O60096              186 HSYNEVMEKML------------NACTKPEMMQf---------------nDGNDIPL-RSNPVSLWKSLPEGETFTPQEA 237 Schizosa...
XP_011389385        186 SEFQSNMDRLL------------GAQDRKRMPE----------------------SEPSVQSTSKSMRGAQHEEFSEADS 231 Ustilago...
Q6CH22              245 AKLLDL--APAADVLEKLQHVVADHSEKAEieFEKaKA---KGQIFDVVKKSE 292 Yarrowia lipolytica
EEQ28823            250 ARVFSA--APELPAAERDVAGNTP-EAIAKvtRAP-HN---IEMVGKGANEQQ 295 Microsporum canis CBS 113480
EAW12787            215 GRVFSA--APALPHEETAHSAANPAEAVSRitQNP-SR---IERVGKGADEHE 261 Aspergillus clavatus NRRL 1
EED51957            230 GRVFSA--APALENKQVN-DAADPAEAVSRitQNP-SH---IEKVGKGEAEQQ 275 Aspergillus flavus NRRL3357
XP_002147453        234 GRVFSA--APALEHGEEAKV-----NVETLitPET-RR---YEKVGKGDEEQQ 275 Talaromyces marneffei ATCC 18224
Q0UEV8              255 GKAFDNnlLPADERIPHPELVLAERELAQGlsFEErRR---LAEERLEAENAE 304 Parastagonospora nodorum SN15
Q2H3W6              222 AKAFGEhiLPPDAKMRIPELVQMEKNIAEGmdEREaRGhfiKEAAESEQAFAE 274 Chaetomium globosum CBS 148.51
WGS:AATM:SJAG_02067 224 AKELGW--PPLSELLASAEAAVSTKASCNDatYEP-TK---LVEKSPFMKSHR 270 Schizosaccharomyces japonicus yFS275
O60096              238 AKILKW--PSIEELNMRQNATHFHKTSDEHkdLNEdEE---LISSSPSEVGKR 285 Schizosaccharomyces pombe 972h-
XP_011389385        232 LDAPSViaPAMAEESLKRASMIAALPSGGPdvDAKsST---KVIKTQRAPLSI 281 Ustilago maydis 521
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