6V4X


Conserved Protein Domain Family
Symplekin_C

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pfam12295: Symplekin_C 
Symplekin tight junction protein C terminal
This domain family is found in eukaryotes, and is approximately 180 amino acids in length. There is a single completely conserved residue P that may be functionally important. Symplekn has been localized, by light and electron microscopy, to the plaque associated with the cytoplasmic face of the tight junction-containing zone (zonula occludens) of polar epithelial cells and of Sertoli cells of testis. However, both the mRNA and the protein can also be detected in a wide range of cell types that do not form tight junctions. Careful analyses have revealed that the protein occurs in all these diverse cells in the nucleoplasm, and only in those cells forming tight junctions is it recruited, partly but specifically, to the plaque structure of the zonula occludens.
Statistics
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PSSM-Id: 403495
View PSSM: pfam12295
Aligned: 51 rows
Threshold Bit Score: 117.713
Threshold Setting Gi: 167517747
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6V4X_J        858 DVRFLIPVLNGLEKKEVIQALPKLIKL-------N-----PIVVKEVFNRLLGTQH-----------GEgnsalsPLNP- 913 
O16929        889 DIRALLPIIGGLEREEVVRLIPTFIFRa-----eY-----QKSVNVLFRKLYTVRD-----------PQtg--nlVFDP- 944  Caenorhabditi...
CAP22763      879 DIRALLPIIFGLEKEEVMQLIPTFIFKt-----eY-----QKSVSTLFRKIYTARD-----------FKtg--elNFDP- 934  Caenorhabditi...
EGT34494      878 DLRALLPIIGGLPKDEVFRLIPAFIFKa-----eY-----QKNVSILFRRIYSVRD-----------PNtg--esIFDP- 933  Caenorhabditi...
EEA05070     1397 NFYLVIPMIGFYEIDIIKQYLPILINTg-----------dKILLKHTIQNILSPDGkh-------leNSri--ksKISS- 1455 Cryptosporidi...
XP_002262257 1908 NIYFIIELVAFLKKEQTVHIFNEIIKSdle-entK-----VDLLKFCINKIVKLPYfyiae--kqneNEne--syYITN- 1976 Plasmodium kn...
Q7RF71         29 NIFFIIELIGFLKKDQTLYIFNEIIKNemd-enkK-----IEILKTCIDNIIKLPYsyvm----ekqNEne--syYITN- 95   Plasmodium yo...
ESS34142     1651 aLRLALPLVAFFDRAQLAVLLPKFIFGef----------sETQMKTALKRLLTIPLel-------qqKAyp--grSVMPp 1711 Toxoplasma go...
Q4N2F1       1090 lnkLLIFLFRKYEKEKIIKVLDVIIETpkvslpqHflysiYNMPTSQISNKLATVVsqs-----tgvPQgt--vsEVTPv 1162 Theileria parva
Q8I5M6       1886 NFEFIIEIIGFLGKEQTLQIFNDIIKNeiieenkK-----IEFMKSCINNIVKLPYayilekkknndNDne--tyYVTN- 1957 Plasmodium fa...
6V4X_J        914 GELLIALHNID--SVk--CDMKSIIKATNLC-F----------AERN------VYTSEVLAVVMQQLMEQ--SPLPMLLM 970 
O16929        945 IEVIKEYHKIEp-KNdneAEL--LVNNLEFL-F----------D-PA------LLKPDTASQAIEAVFKW--ENVPFLFL 1001 Caenorhabditi...
CAP22763      935 VDVIQRYHKIEp-KDdheAEL--LVNNLESL-F----------D-PA------VLKPDLASKGIEAIFKW--EQVPFLFL 991  Caenorhabditi...
EGT34494      934 VEIITEYHKIEa-KDdkeAEL--LVKHLEYL-F----------D-AT------HLKPDIASQAIETIFRW--DDVPFLFL 990  Caenorhabditi...
EEA05070     1456 EDLLRMAVSYSy-PEvknVDARRAVDIVDCC-F----------ELTQis--ppLFDSDTIASVLGRFAQEdmPTFPRTLG 1521 Cryptosporidi...
XP_002262257 1977 IEIFYFYYNLNknKNiqkIMLDYFVTKVNLHtV----------DDQEnkm-fnDITIKDLANIIQQIAENs-NAIFPIYG 2044 Plasmodium kn...
Q7RF71         96 IEIFYFYYNLNknKNiqrIMLDYFVTKVNLNqL----------DDQEnnkmtnDITIKDIANIIQQIAENt-DSIFPIYG 164  Plasmodium yo...
ESS34142     1712 EDILMLLYNLP---CttsQQRKKQTTVLDFC-LdltgctsraeSPTE------IFPIDVIATTCQRIADDdsQPISVIFG 1781 Toxoplasma go...
Q4N2F1       1163 ------------tPVdekDYMKLQVLLLDTC-I----------KYCTl----gRFSVESAISSLYLIVESf-DNINFVFG 1214 Theileria parva
Q8I5M6       1958 ADIFYLYYNLNkyKNiqrVMLDYFVTKVNLNtI----------DNDDntkmfnDITIKDLASIVQQIAENs-NTIFPIYG 2026 Plasmodium fa...
6V4X_J        971 RTVIQSLTMYPRLGGFV-MNILSRLIM-KQVWKY-PKVWEGFIKCCQ----RTKPQSFQVIL-QLPPQQLGAVFDKC 1039
O16929       1002 HSLYTLFHKFKTFESFV-ANLFYKVTE-KKMYQQsDRWKQAFFKCIK----ELKTKAYPAVItFLSFEEYEELKEvl 1072 Caenorhabditis e...
CAP22763      992 HSLYTLYHKFKTFDSFV-ANLFYKVTE-KKMYQQsDRWKKAFFKCIR----EMKAKAYPAVLiLISFEEYEELKAel 1062 Caenorhabditis b...
EGT34494      991 HSLYHLYRKFK-FDSFV-ANLFYKVTE-KRMYQQsERWKQAFHTCIK----ELKTKAYPAVLcLATWEEYEELKALl 1060 Caenorhabditis b...
EEA05070     1522 RAMVLSILYIPSIKPFIaSFVISSLIRsRRVWDD-TLTWRGIRHCIQklwtDYKNILLPSLI-LLPRSEFEVIFHEL 1596 Cryptosporidium ...
XP_002262257 2045 RFLCQISKNINILREFIsSIIIPLLIQ-KKIWNN-KVIWKGCLMCISmlwpDFKHSLFYVFF-MLPADECATLFNAL 2118 Plasmodium knowl...
Q7RF71        165 RFLCQVTKNINILREFVsSIIIPLLIQ-KKIWTN-KFIWKGCLMCISmlwpDFKHSLFYIFF-MLPEAECAMLFNSL 238  Plasmodium yoeli...
ESS34142     1782 RLLCQVAQNIPSLREFVaGTVMPALVR-RKIWTN-RSLWKGFVMATSilwaERKDLLVRMIL-VLPEDRTRDLLQHL 1855 Toxoplasma gondi...
Q4N2F1       1215 RLLCQFVQKVPLTRKVIvDVIFPKLIQ-KQCWQD-KQLFKGVVITICtlwnHFKDHLLRYIL-EMPNSNVKTVLKAL 1288 Theileria parva
Q8I5M6       2027 RFLCQITKNINILREFVsSIIIPLLIQ-KKIWTN-KFIWKGCLMCISmlwpDFKHSLFYIFF-MLPSDECSTLFHAL 2100 Plasmodium falci...
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