Conserved Protein Domain Family
HoxA13_N

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pfam12284: HoxA13_N 
Hox protein A13 N terminal
This family of proteins is found in eukaryotes. Proteins in this family are typically between 149 and 306 amino acids in length. The family is found in association with pfam00046. This family is the N terminal of the Hox gene protein involved in formation of the digital arch of the hands and feet as well as in correct genital formation. Mutation of the protein is associated with hand-foot-genital syndrome.
Statistics
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PSSM-Id: 403486
View PSSM: pfam12284
Aligned: 20 rows
Threshold Bit Score: 67.9835
Threshold Setting Gi: 511890491
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q3V614        28 SKNMDGLvGGGNFatAASQCRNIMAhsaaaaalggHASGLMHSs-----AGFSTVDVSTSGSGETaatsGKQCAagqcaA 102 Japanese medaka
XP_005995687  31 NPGMEGL--SGNC--PATHCRDLIShpa----lgrHSSTIATHq----gPVYSDIAAPEAG---------RQC------- 82  coelacanth
XP_004070510  31 SQTMEGL--SGNC--PATHCRDLMShpa----lgrHSGTIATHq----gSVYSDISSPDTG---------RQC------- 82  Japanese medaka
Q3V600        31 SQTMEGL--SGNC--PATHCRDLMShpa----lgrHSGTIATHq----gSVYSDISSPDTG---------RQC------- 82  Japanese medaka
OCA46671      31 spAMEGL--SGNC--ASSHCRDFIShpa----lgrHSSAIGSHq----gPVYTDITSPEAA---------RQC------- 82  tropical clawed...
P50207        52 apSMDGL--GGSC--PASHCRDLLPhpv----larPPAPLGAPq----gAVYTDIPAPEAA---------RQCA-----P 105 house mouse
OCA23571      10 qWEMEGLrGGGEGp-SSNQCRNFLSsps----vfgSPSSRTVPg-----LAYSAPDRSGSARAEAt----KEGP-----T 70  tropical clawed...
XP_004764951  12 AKAMEGLpGAG-------GSRNLAArsp----lpsHPAAAGAPpllpaaVSYAPLDLPGSAEPP------KQCH-----P 69  domestic ferret
XP_006638382  27 NKNMEGLvGAGNF--AANQCRNLMAhsa----lggHPSTLVHGs------GYSAVDVSGSGSGEP----GKQCA-----P 85  spotted gar
XP_007232293  27 NKNMEGLvGSGNF--AANQCRNLMAhsa----lsaHPSSLVHGs------SYSTVEVSTSSAAET----SKQCT-----P 85  Mexican tetra
Q3V614       103 AAAMphQSSSAAtALPYGYF-GNGYYPCRMGR-----GSLKSCT--QAAG--AALSSQYMDTTVS--PDEYP 162 Japanese medaka
XP_005995687  83 -PAP--QTSSSA-TLGYGYPfGGTYYGCRLSHshnvnLQQKPCS--------YHPAEKYAETSSSlpSEELS 142 coelacanth
XP_004070510  83 -PAP--QSSSSA-SLSYGYPfGNPYYGCRLSHshnvnLQQKPCS--------YHPAEKYAEPSTAlpSEELS 142 Japanese medaka
Q3V600        83 -PAP--QSSSSA-SLSYGYPfGNPYYGCRLSHshnvnLQQKPCS--------YHPAEKYAEPSTAlpSEELS 142 Japanese medaka
OCA46671      83 -TAP--PSSSNA-SLGYAYPfGSSYYGCRLSQshnvnLHQKPCS--------YHPAEKYPEPSNPlpSEEFS 142 tropical clawed frog
P50207       106 PPAP--PTSSSA-TLGYGYPfGGSYYGCRLSHnv--nLQQKPCA--------YHPGDKYPEPSGAlpGDDLS 164 house mouse
OCA23571      71 CPAS--TGPSGP-SLGYGYHfGNGYYSCRMSHgv--gLQQNPLKssSHASlgGFPVEKYMDVSGL------A 131 tropical clawed frog
XP_004764951  70 CPGVp-QGTAPA-AVPYGYF-GGGYYSCRVSR-----SSLKPCA--QAATlaAYPAE----TAAP--GEEYP 125 domestic ferret
XP_006638382  86 CPAVp-QGTSTApPLPYGYF-GNGYYSCRMGR-----GSLKSCT--QPGAlsSYSAEKYMDTPVP--SEEYP 146 spotted gar
XP_007232293  86 CPTVp-QASSTG-PIPYGYF-GNSYYPCRMGR-----GSLKSCT--QPSAl-SYTAEKYMDTPVT--SEEYP 144 Mexican tetra
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