Conserved Protein Domain Family
NTP_transf_8

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pfam12281: NTP_transf_8 
Nucleotidyltransferase
This is a family of bacterial proteins that have a nucleotidyltransferase fold. The fold-prediction is backed up by conservation of three highly characteristic sequence motifs found in all other nucleotidyl transferases: i) pDhDhhh(h/p), where p is a polar residue and h is a hydrophobic residue; ii) upstream of the first, a GG/S; iii) a conserved D/E in a hydrophobic surround. In the classification of nucleotidyltransferases proposed in this is a group XVIII NTP-transferase. Many of these sequences were classified in the COG database as COG5397. The exact function is not known.
Statistics
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PSSM-Id: 403484
View PSSM: pfam12281
Aligned: 32 rows
Threshold Bit Score: 146.668
Threshold Setting Gi: 81737313
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q12C53        118 IEVLNAMMRYG-VSEHFLVVGTHALFAYETAAGVRLP-SDVMATQDADLlfDTARKAAFMEVMk--dRKMSFLGILKKVD 193 Polaromonas sp...
jgi:Daci_2532   5 HAFAKLVKALSpWRGQLVFIGGWSHRLHSLHPQANRQeHQPVFTRDTDLafANKAP-----------IEGDMRSALAAHG 73  Delftia acidov...
jgi:Ppro_0100  16 TDLLRELSGIGfF-THGLLIGSWPMVVYAEHFTLMYG----LRTGDIDFavIGAMRVPPA-------PPETVPEVLDRLG 83  Pelobacter pro...
Q3IV36        116 ARVIRKFEDLGwLGRTLLVLGTNALYAYEAAAAVRIE-AGMLATGDVDVlyDARRKLVM--SGe--vGERGLIGALQSVD 190 Rhodobacter sp...
vbi:Arad_4314 108 ARILRALNKANlIGNALDIVGTNALFAYERLSGVKID-SSLLATGDIDLlfDARTNLNLL-RRs--iGAEGLMGVLRTAD 183 Agrobacterium ...
BAF87688      135 AKIIRALDEAGlLGAGIRVAGTNAVYAYEAAAGVFVD-AGVTATQDIDLlmDARRTLRILSSEd--vPEGALLNLLRQVD 211 Azorhizobium c...
jgi:Oant_0601 118 ARIIRAVDNAGlLGAGIRIVGTNAIFAYEAIAGVFVD-PGITATDDIDLlmDARRSLKMVVDDd--iKNNSLLGLLKKVD 194 Ochrobactrum a...
Q5P6X2        112 GEVLLALAASN-VARDFCVVGTHAIHGYEAMAGVHCQ-MELLASGDVDLlyDPRRRLALV-TDk--lEGDGLLGLLQKVD 186 Aromatoleum ar...
jgi:Mpe_B0625 113 ADVCSELDAAQlMGKSMMVIGTNAMHAYAYLAGVRFQ-ADIMATTDVDLlwNHKAKLSLMATAe--vSKDGLLGLLQRCD 189 Methylibium pe...
jgi:Slit_0852 112 VGLLEEIRRTG-LQDHFMVIGTNALYAYETQAGVRFN-GDVTATTDMDLlwDSRKRITLAADGdehfNKYGLIGVLKKID 189 Sideroxydans l...
Q12C53        194 KTFERDELDNSTAR------NASGYEIDLIRRFPPDPEdtlEHplQLTPEEgDLWPVRASMGQKLLSVPrFDQVVVGVNG 267 Polaromonas sp...
jgi:Daci_2532  74 FTEQLAGEFKPPAAhytlgsDSKGFYAEFLTPLSGSGRkrdGTpdATMEKA-GISAQKIRHLEILLVDP-WVVTAGPQNG 151 Delftia acidov...
jgi:Ppro_0100  84 YS----PVQDYDAGie--tfLHGEFEVEFITHRKGGGRge----gSVLVQPwKVAAQPLPFIDLLFVRP-VTIVIED--- 149 Pelobacter pro...
Q3IV36        191 RSFQPVGRRSYTAA------NKDGYMVDLLEPLDYDRVmrqGPa-RMSAAPdDLVAVSTESSRWLLNVPkFSATTFDEKG 263 Rhodobacter sp...
vbi:Arad_4314 184 KSFHALGKRSFRAA------NKDGYLVDLIGPMPSRPLnssRPa-GIGENEdDLAAVEIEGLQWLINSPkVTAIVLDERG 256 Agrobacterium ...
BAF87688      212 RSFERT-RETFRAI------NRDGYLIDLIKPDPRPPWkmeRD--RIGSGEdDLVAASMEGLAWLENARpFEAIAIDEKG 282 Azorhizobium c...
jgi:Oant_0601 195 KSFERT-RSSYRAA------NREGYLVDLIKPPAKPIWresRE--SIGNGEdELVAAAIEGLDWLENSPpFEAIAIDEKG 265 Ochrobactrum a...
Q5P6X2        187 ASFERLPDTRFRAA------NSNGFMVDLIIPERDLQIt-----eAVTFGAdDLVAVEVPNLHWLVNAPkLDVVAIAANG 255 Aromatoleum ar...
jgi:Mpe_B0625 190 KTYVQDPRQRFRAR------SSTGFMVDLIRQMPEPPWadePD--RLAKN--DLVATDISNMDWLLSAPrIEQPAVAVDG 259 Methylibium pe...
jgi:Slit_0852 190 PTFELLKDQEYSAA------NSQGYMIDLIKRRPASFFddkEHp-QLIANPdDFWATKIKNMDWLLSSPkFRQVVVGTNG 262 Sideroxydans l...
Q12C53        268 a----mARMRTVHPLDFARIKRQLSKD---INREPLKKAKDLAQADMVETLVREYLpHLAKDLA 324 Polaromonas sp. JS666
jgi:Daci_2532 152 ipleapVDLQVANPLCFMVQKLLIK-----KDRKPAKHAQDLLYIYDTISLFGHLL--PLFKDC 208 Delftia acidovorans SPH-1
jgi:Ppro_0100 150 ------FSISIPSPEALMLHKLIIAQRrtgKDKE-LKKEKDLQQCSVLVEVARPEEvQQLLAEY 206 Pelobacter propionicus DSM 2379
Q3IV36        264 l----pVRIVTIDPRAFALQKQWILENd--PTRDPAKRRRDGEQARLVAKLAVRHL-GLSFNDS 320 Rhodobacter sphaeroides 2.4.1
vbi:Arad_4314 257 y----pVHYTCPDPRSFALHKLWLSRR---EDRDPLKKLRDEAQAYVVADMIGRYVpHLRFDDT 313 Agrobacterium radiobacter K84
BAF87688      283 w----pVRMVCPDPRVFAAHKLWLSGR---VDRDPPKRRRDEAQAAVVGRLTAAYLtHLPYEGD 339 Azorhizobium caulinodans ORS 571
jgi:Oant_0601 266 e----pLRIVAPDPRIFAAHKFWISQR---GDREPVKRQRDRAQAETVAQLTTTYFkHLPYEAS 322 Ochrobactrum anthropi ATCC 49188
Q5P6X2        256 a----pVMMRVPDPRAFALHKAWLSQQ---PDREPVKKRRDRAQAVMVAALVQTHLpALPFDTA 312 Aromatoleum aromaticum EbN1
jgi:Mpe_B0625 260 r----vFMMTAPDPRAFAAFKVWLSQE---PGRDPLKKGRDIAQARAVLRVLEERLpHLPLIEA 316 Methylibium petroleiphilum PM1
jgi:Slit_0852 263 s----mAEMVTVDPRAFVFYKTWLSQK---EDRNPMKKPRDLAQARAVYQLLQERLpQLSFDKi 319 Sideroxydans lithotrophicus ES-1
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