Conserved Protein Domain Family
PIP49_C

?
pfam12260: PIP49_C 
Protein-kinase domain of FAM69
This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localized to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain.
Statistics
?
PSSM-Id: 403470
View PSSM: pfam12260
Aligned: 30 rows
Threshold Bit Score: 139.739
Threshold Setting Gi: 212517868
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_002604567 242 FLKLLQktfdDNgNKRlnrLEQAIPRK-Kl--PIPAFLGACGNLVATETAG--KPlsm-----yleVKGPWQVRANLSLQ 311 Florida lancelet
XP_697696    194 LYTLAV----NQ-QPL---ILQMFPGT-Eg-wPFLRYHGSCGRLMVWAASRalRTl----------FSSPLERRADLAYQ 253 zebrafish
XP_416761    208 LYTLSV----NS-HPI---LLQIFPDV-Eg-wPFPRYLGSCGRLVVSASTRplr----------dfFRAAPEVAADLALQ 267 chicken
XP_002593078 195 LSTLKF----NP-EPL---MLQTFPIT-Eg-wPFPFYFGACGRLTVVQKCDktl---------asyYSAPWLKRVELSLQ 255 Florida lancelet
VFV43512      49 LLTLAF----NP-EPL---VLQSFPSD-Eg-wPFAKYLGACGRMVAVNYVGe-ELws--------yFNAPWEKRVDLAWQ 109 Spanish lynx
XP_001637923 193 LITGLHl---NP-ELL---LLQIFRQE-Eg-wPFPRFYGVCGRIMVVEDSG--PPis-------sfLEESWDVRAQIAVN 254 starlet sea ane...
XP_002434016 195 AYTASV----NP-EPL---ILQAFPRR-Dg-wPFPEFCGSCGRL-VVESYEgtPLsq--------fELFDWSVRAHLANR 255 black-legged tick
EEB19697      62 LWSFLD----VSiEPL---LMLSLGK--S---GFPKYIGACGDFLVEEYKGlpl---------dnfLSCDFKTRALLSIK 120 human body louse
Q176Y7       184 SWNLIQ----NH-EFV---MAVMFNEN-D---LFPYVEGNCAEMFASEKLNavEFdenrsyfgshiTLDRWRYHIKMAVL 251 yellow fever mo...
XP_002591750 301 ITALLL----NP-EAA---LLKHFTSRaEeywPFPKYLGACGRVILVESGG--KLlg-------saIESPWKERANIALQ 363 Florida lancelet
XP_002604567 312 LLQMLDDFQNKDPDWlLMFVEVNIENFSVS-SDGRLILTDLGNMTIINKhdldKNS-TKKRSsv--cN--------EACF 379 Florida lancelet
XP_697696    254 LLHITQSLSANSLRFrLFYTRIPEDMFGIL-EDNKVFIVDTSTIGIIDL----QEG-HPPDK-----Dll-----pEELD 317 zebrafish
XP_416761    268 LLAVLHSMGTNDLNYfFYFTRVDVGTFGVF-SNGHLFIRDASTLGIIDKeegsQPI-DGQQE-----Y--------KD-- 330 chicken
XP_002593078 256 MMKIAEYLTNNEADFgLYLTDISYENFGVT-SDGNLFVIDVENVIVVDKq--kIKA-DKPRN-----WearyqshfDECP 326 Florida lancelet
VFV43512     110 LMEIAEQLTNNDFEFaLYLLDVSFDNFAVGpRDGKVIIVDAENVLVADKr--lIRQ-NKPEN-----WdvwyeskfDDCD 181 Spanish lynx
XP_001637923 255 LITLAHQLSSALDDWaLYIADPAPGNFGVS-DSGKVTLLDLEHLVVVDLsevqMEEaNDKPK-----P--------SDCS 320 starlet sea ane...
XP_002434016 256 LLDLAQLLTENPTEFaLYLTDVSMDNFAVD-AMGQVTVVDAENVIVVDQr--eVREgQKPGW-----Dkry--ehlEE-A 324 black-legged tick
EEB19697     121 LLNLANFFTFSSSDFiFYFTDISLYNIVVD-EHGNVSLVDLDNVIIFDKksqkSSS-VKAKIhkteiW--------NDn- 189 human body louse
Q176Y7       252 ILDYMDELDQ---HG-IQMCHVDLSRFGIN-NN-RLKYDDLRFVFTDYTinrkISSgSYCAR-----D--------EHCN 312 yellow fever mo...
XP_002591750 364 LLEMIDKFRNGDPKWvVIFVDFSFNNFAVN-NYGRLTLIDFDDVMLIDRee-fVGE-NKTEPc----D--------LKCF 428 Florida lancelet
XP_002604567 380 K-RFTRN-LSHRPETSCRQAGR--YSQlmYARACQR-I------LGCWqtersgegrvvlssskdascaygrglLFGP-- 446 Florida lancelet
XP_697696    318 V-FSCLS-GSCVRPPPCETVRE--AQS--FILLCKY-I------LNNL--------------------------LTSNd- 357 zebrafish
XP_416761    331 I-FSCLTvDCQSAFVSCNSIRE--KQS--LVMVCQE-L------LPKL--------------------------LRGKf- 371 chicken
XP_002593078 327 GmSNCLS-FD--VSALCRYLHT--DHN--YYAVCRNmL------SEYAsemgk-----------------pgglLHDP-- 374 Florida lancelet
VFV43512     182 K-EACLS-FSK--EILCARATV--DHN--YYAVCQN-L------LSRHatwrg----------------tsgglLHDP-- 228 Spanish lynx
XP_001637923 321 Q-PDCLS-FSP--SDMCSGGSR--DHN--YYAICQG-VlagssrRQGL--------------------------LHNP-- 363 starlet sea ane...
XP_002434016 325 C-HDCLS-FSS--EDLCSHQLA--DHN--YFAVCSG-Ll-----APRAfyss------------------vgglLHSV-- 370 black-legged tick
EEB19697     190 --DDDYS-FSS--SDICSHYLS--DHN--YYSICTH-I------LSHSdy----------------------glLKEI-- 229 human body louse
Q176Y7       313 F-MHCKS-ECNVEKNRCESTVM--NNN--VQIVCDK-I------FLGS--------------------------KRYPgi 353 yellow fever mo...
XP_002591750 429 KtFISQI-EAMNSYDSCSAMPQysQMM--YALACVR-L------LSHLpehlsepnpmdpkpdkhrpdserprlLWGP-- 496 Florida lancelet
XP_002604567 447 --PR---EAKQE--LEDLLTECVEE 464 Florida lancelet
XP_697696    358 -kQS---GLPRA--AVDELLVCADP 376 zebrafish
XP_416761    372 --LP---PVQEK--IDSFLQHCAEG 389 chicken
XP_002593078 375 --PE---TVVRDgtLQRLLAECAKP 394 Florida lancelet
VFV43512     229 --PS---EIAKDgrLEALLDECANP 248 Spanish lynx
XP_001637923 364 --PV---ALKAS--LNQLLQDCTAQ 381 starlet sea anemone
XP_002434016 371 --PP---DVEKQhgLSALLAACDRP 390 black-legged tick
EEB19697     230 --PRtitNLNPD--LEFLLNECKKP 250 human body louse
Q176Y7       354 liTQ---KTPDR--LHMLLERCANP 373 yellow fever mosquito
XP_002591750 497 --PE---QEAKV--LEELLRGCVEE 514 Florida lancelet
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap