Conserved Protein Domain Family
MKT1_C

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pfam12246: MKT1_C 
Temperature dependent protein affecting M2 dsRNA replication
This domain family is found in eukaryotes, and is typically between 231 and 255 amino acids in length. There is a single completely conserved residue P that may be functionally important. MKT1 is required for maintenance of K2 toxin above 30 degrees C in strains with the L-A-HN variant of the L-A double-stranded RNA virus of Saccharomyces cerevisiae. MKT1 is a 93 kDa protein with serine-rich regions and the retroviral protease signature, DTG. This family is the C terminal region of MKT1.
Statistics
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PSSM-Id: 432422
Aligned: 83 rows
Threshold Bit Score: 131.162
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002545700 533 RTLYLYGILNDk-----KEVSPLAKVLIKFANEIdvsqQEEfEQFVLLLLLLQSKSIVLNePSKEFTDvsnyykqwgsss 607
XP_003675123 550 RMLYQLEFFDFdssknlLKPTKWGTILLKLNELEi--sANYfESILIFLMFVKMNVLSLSeELKPVVRfa---------- 617
CCD23435     568 RVLTQLEFFDFniptksLKPTKLGSVLLNLPKLSi--dDKHyDSILLLLIFLKTKVMSLSeDVKPSVRsa---------- 635
XP_003959380 582 RSLVQLEFFEYnfsqriLKPTKWGEVLLKFNDLSi--dSKFhERLLVLLVFLKLDTLKLSeEIKPVVRsa---------- 649
CCK70425     563 RLLIQLEFFDFdfgeksLTPNQWGRAFLKLGNLGa--eSDFvGKLFILLVFLKTKVLSISqDFTPSVRss---------- 630
P40850       574 RLLVLLEFFTFdfkeklLEPTRWGEVFLKLNELNi--dSKYhESVIIFLVFLKCDVLKLDeEVQPPAPsa---------- 641 Saccharomyces c...
CCH61414     642 RTLYLLEFLEFdfskriLKPTKWGEILLKLNDLNi--sEKYfEPILILLVFLKLNVLNLSdDTQPSIPsa---------- 709
XP_002555402 545 RFLSLLGFFDFdssqktLKVTPWGRILLDMTKTGv--dSESiEPVFVLLMFLKTGVLSLReETVPATPsa---------- 612
XP_003646944 518 RFLYLLGFFEHdn---gLQPTPYGKVLLKFGELGi--nESFyEMYLVLLMFFKIDVLKLSeETRPPTQsa---------- 582
Q755V4       517 RLLSLLGFFKYes---tLKPTKYGEALMKFNELNl--eLEFyEPFLVLLMFFKLGVLKLGeETQPPTQsa---------- 581 Eremothecium go...
XP_002545700 608 tdqpqqsgtgaQYKRDsISQEDLKKITLISRIFSFNKFNIGPIN-YQGPVSRSLLNFRSQIEFLNKNLLNSLQVVLVDLI 686
XP_003675123 618 ----------lSDSTLrSYPQESQYVLLITRILTLFQVDQKPTN-YHGPIDKRTLVFREHLDFIKKNMNELYEATIVSSL 686
CCD23435     636 ----------lSDVTLrTYPQESQYILLITRILTLFQINQRPTN-YHGPIDKKTLIFREHLDFIRENMNEIYEATLISSL 704
XP_003959380 650 ----------lSDHTLrSYPQESTYILLLTRLLTLYQVEQKPSN-YHGPIDKKTLIFREHLDYVRDNLKNLFEATIISSL 718
CCK70425     631 ----------lSDHTLrSYPQESKYILALTRLLTLFQVDQKPTAiYHGPIDKKTLTFREHLDFVNDNLNDLFESLVVSSL 700
P40850       642 ----------lSQATLrSYPEESLYVLLITRVLTLFQVDQKPSN-YHGPIDKKTLIFRDHLSFIKENLNELFEAVLISSL 710 Saccharomyces c...
CCH61414     710 ----------lSQVTLrSYPLESSYILLITRILTLFQIEQKPSH-YHGPIDKKTLVFRDHLDFVKVNLKELYEAVTIASL 778
XP_002555402 613 ----------lSKATLrSYSKESSYILVLTRILSIFRLQQKPSN-YHGPIDRKTLVFRDHLDYVKENLNDLFEVTLVSSL 681
XP_003646944 583 ----------lSQATLrSYPKESLCILALTRVLTLFQLNQKPSK-YYGPIDKKTLIFREYLDYIKQNMSELFEAVLVSSL 651
Q755V4       582 ----------lSQVTLrSYPKESQCILCLTRVLTLFKLRQKPAN-YYGPIDKKTLTFREHLDYVKQNISELFEAVLVSSL 650 Eremothecium go...
XP_002545700 687 VHQEQNEiksfEsKqDW-YNLINNLPFYKSInNYLMGVIGEIYFEICAkqkqgddEVRKKNAMNHLCDFVFqvnlptfni 765
XP_003675123 687 TANEFDRls-lD-NnEWqKNIVRNAPFKSSSpNTLMAMMWEFFLQKYLh------NGNVKTDAMAMVATEFg-------- 750
CCD23435     705 TANEFDRls-lD-NfEWqSKVVRNMPFKLATpNTIMAMMWEFFLQKYLh------NGNVKTDALALVATEFg-------- 768
XP_003959380 719 TSNEFDRls-lD-NnDWkTSIVHKMPFKLALpNTIMAMMIQFFLQKYLh------NGNAKNDALTLVATEFs-------- 782
CCK70425     701 TANEFDKls-lQ-NhEWqSEIVYHMPFKRSLpNTVMSMMVEFFLQKYLh------NGNIKHDALALVSTEFs-------- 764
P40850       711 TSGEFNRls-lD-NfGWaRKIVRYLPFKLDSpNTIMAMMWEFFLQKYLh------NGNAKNDALSLVATEFn-------- 774 Saccharomyces c...
CCH61414     779 TSGEFLRln-mD-DnAWrNKIVGDLPFKSSSpNTIMAMMWEFFLQKFLh------NGNAKNDALTLVTTEFn-------- 842
XP_002555402 682 AAGEFDRls-lD-NtGWqKKIVAAMPFKLSTpSTVMAMIWQFYLQKFLh------NGNSKSDALNLIASTFn-------- 745
XP_003646944 652 ATSEFDRls-lD-NsGWqHKIVNHIPFKLSTpNTVMAMIWEFYLQKWLh------NGQDKQDALALVANAFs-------- 715
Q755V4       651 AAGEFNRiq-lD-NaEWqQKIVGNAPFKVSTpNTVMAMMWEFYLQKWLh------NGQDKQDALALVSNSFs-------- 714 Eremothecium go...
XP_002545700 766 nvhgiNAinKDQLISDFKKSVSFWGKFVKLSEITNGidkNLISDKFLEEIKQTDIFLQK 824
XP_003675123 751 -----TYksIPNLEEQFEISHEFLVQVSKVMQELTSv--GLLKKGDQNSFEQAVKFSEd 802
CCD23435     769 -----TYksVPNLNEQFEHSYEYLMQILKVLKELNAi--GLFDRKDLKIVEEALEFCSN 820
XP_003959380 783 -----TYktIPDLGEQFENAVEYLTQCVNLVKELSSq--RLMKNDEAALIAKAVEFTKN 834
CCK70425     765 -----TYkcVPNLTEQFDQSIAYLSQCKVLFDELCDm--KLVSKDESELLSEAVTFATN 816
P40850       775 -----TYksTPNLDEQFVESHRFLLEISKVMQELNAa--KLIDENVFKLFTKAVEFTTT 826 Saccharomyces cerevisiae S288C
CCH61414     843 -----TYrsTPNLEGQFKNSLEFLEQVSSVFNELLKv--GLVTENNTKLLSNAVEFART 894
XP_002555402 746 -----TSkvVPNLDEELKRSLDFARQFGQVLGALSKa--NLCEKQDYELVVEAVEFAEK 797
XP_003646944 716 -----THkyVTNLAEELERASNYLKDVGVIFGSMKDl--KLINDADFELFNDALKFSNK 767
Q755V4       715 -----AYkhVPNLEEEMKRALKYLENVKSLLGVMHAl--DLIQESEYELFNDAAAFANK 766 Eremothecium gossypii
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