Conserved Protein Domain Family
MKT1_C

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pfam12246: MKT1_C 
Temperature dependent protein affecting M2 dsRNA replication
This domain family is found in eukaryotes, and is typically between 231 and 255 amino acids in length. There is a single completely conserved residue P that may be functionally important. MKT1 is required for maintenance of K2 toxin above 30 degrees C in strains with the L-A-HN variant of the L-A double-stranded RNA virus of Saccharomyces cerevisiae. MKT1 is a 93 kDa protein with serine-rich regions and the retroviral protease signature, DTG. This family is the C terminal region of MKT1.
Statistics
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PSSM-Id: 403458
View PSSM: pfam12246
Aligned: 85 rows
Threshold Bit Score: 129.229
Threshold Setting Gi: 122051857
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002545700 533 RTLYLYGILNDk-----KEVSPLAKVLIKFANEIdvsqQEEfEQFVLLLLLLQSKSIVLNEPSKEFTDvsnyykqwgsss 607 Candida tropica...
XP_003675123 550 RMLYQLEFFDFdssknlLKPTKWGTILLKLNELEi--sANYfESILIFLMFVKMNVLSLSEELKPVVRfa---------- 617 Naumovozyma cas...
CCD23435     568 RVLTQLEFFDFniptksLKPTKLGSVLLNLPKLSi--dDKHyDSILLLLIFLKTKVMSLSEDVKPSVRsa---------- 635 Naumovozyma dai...
XP_003959380 582 RSLVQLEFFEYnfsqriLKPTKWGEVLLKFNDLSi--dSKFhERLLVLLVFLKLDTLKLSEEIKPVVRsa---------- 649 Kazachstania af...
CCK70425     563 RLLIQLEFFDFdfgeksLTPNQWGRAFLKLGNLGa--eSDFvGKLFILLVFLKTKVLSISQDFTPSVRss---------- 630 Kazachstania na...
P40850       574 RLLVLLEFFTFdfkeklLEPTRWGEVFLKLNELNi--dSKYhESVIIFLVFLKCDVLKLDEEVQPPAPsa---------- 641 Saccharomyces c...
CCH61414     642 RTLYLLEFLEFdfskriLKPTKWGEILLKLNDLNi--sEKYfEPILILLVFLKLNVLNLSDDTQPSIPsa---------- 709 Tetrapisispora ...
XP_002555402 545 RFLSLLGFFDFdssqktLKVTPWGRILLDMTKTGv--dSESiEPVFVLLMFLKTGVLSLREETVPATPsa---------- 612 Lachancea therm...
XP_003646944 518 RFLYLLGFFEHdn---gLQPTPYGKVLLKFGELGi--nESFyEMYLVLLMFFKIDVLKLSEETRPPTQsa---------- 582 Eremothecium cy...
Q755V4       517 RLLSLLGFFKYes---tLKPTKYGEALMKFNELNl--eLEFyEPFLVLLMFFKLGVLKLGEETQPPTQsa---------- 581 Eremothecium go...
XP_002545700 608 tdqpqqsgtgaQYKRDsISQEDLKKITLISRIFSFNKFNIGPIN-YQGPVSRSLLNFRSQIEFLNKNLLNSLQVVLVDLI 686 Candida tropica...
XP_003675123 618 ----------lSDSTLrSYPQESQYVLLITRILTLFQVDQKPTN-YHGPIDKRTLVFREHLDFIKKNMNELYEATIVSSL 686 Naumovozyma cas...
CCD23435     636 ----------lSDVTLrTYPQESQYILLITRILTLFQINQRPTN-YHGPIDKKTLIFREHLDFIRENMNEIYEATLISSL 704 Naumovozyma dai...
XP_003959380 650 ----------lSDHTLrSYPQESTYILLLTRLLTLYQVEQKPSN-YHGPIDKKTLIFREHLDYVRDNLKNLFEATIISSL 718 Kazachstania af...
CCK70425     631 ----------lSDHTLrSYPQESKYILALTRLLTLFQVDQKPTAiYHGPIDKKTLTFREHLDFVNDNLNDLFESLVVSSL 700 Kazachstania na...
P40850       642 ----------lSQATLrSYPEESLYVLLITRVLTLFQVDQKPSN-YHGPIDKKTLIFRDHLSFIKENLNELFEAVLISSL 710 Saccharomyces c...
CCH61414     710 ----------lSQVTLrSYPLESSYILLITRILTLFQIEQKPSH-YHGPIDKKTLVFRDHLDFVKVNLKELYEAVTIASL 778 Tetrapisispora ...
XP_002555402 613 ----------lSKATLrSYSKESSYILVLTRILSIFRLQQKPSN-YHGPIDRKTLVFRDHLDYVKENLNDLFEVTLVSSL 681 Lachancea therm...
XP_003646944 583 ----------lSQATLrSYPKESLCILALTRVLTLFQLNQKPSK-YYGPIDKKTLIFREYLDYIKQNMSELFEAVLVSSL 651 Eremothecium cy...
Q755V4       582 ----------lSQVTLrSYPKESQCILCLTRVLTLFKLRQKPAN-YYGPIDKKTLTFREHLDYVKQNISELFEAVLVSSL 650 Eremothecium go...
XP_002545700 687 VHQEQNEiksfEsKqDW-YNLINNLPFYKSInNYLMGVIGEIYFEICAKqkqgddEVRKKNAMNHLCDFVFqvnlptfni 765 Candida tropica...
XP_003675123 687 TANEFDRls-lD-NnEWqKNIVRNAPFKSSSpNTLMAMMWEFFLQKYLH------NGNVKTDAMAMVATEFg-------- 750 Naumovozyma cas...
CCD23435     705 TANEFDRls-lD-NfEWqSKVVRNMPFKLATpNTIMAMMWEFFLQKYLH------NGNVKTDALALVATEFg-------- 768 Naumovozyma dai...
XP_003959380 719 TSNEFDRls-lD-NnDWkTSIVHKMPFKLALpNTIMAMMIQFFLQKYLH------NGNAKNDALTLVATEFs-------- 782 Kazachstania af...
CCK70425     701 TANEFDKls-lQ-NhEWqSEIVYHMPFKRSLpNTVMSMMVEFFLQKYLH------NGNIKHDALALVSTEFs-------- 764 Kazachstania na...
P40850       711 TSGEFNRls-lD-NfGWaRKIVRYLPFKLDSpNTIMAMMWEFFLQKYLH------NGNAKNDALSLVATEFn-------- 774 Saccharomyces c...
CCH61414     779 TSGEFLRln-mD-DnAWrNKIVGDLPFKSSSpNTIMAMMWEFFLQKFLH------NGNAKNDALTLVTTEFn-------- 842 Tetrapisispora ...
XP_002555402 682 AAGEFDRls-lD-NtGWqKKIVAAMPFKLSTpSTVMAMIWQFYLQKFLH------NGNSKSDALNLIASTFn-------- 745 Lachancea therm...
XP_003646944 652 ATSEFDRls-lD-NsGWqHKIVNHIPFKLSTpNTVMAMIWEFYLQKWLH------NGQDKQDALALVANAFs-------- 715 Eremothecium cy...
Q755V4       651 AAGEFNRiq-lD-NaEWqQKIVGNAPFKVSTpNTVMAMMWEFYLQKWLH------NGQDKQDALALVSNSFs-------- 714 Eremothecium go...
XP_002545700 766 nvhgiNAinKDQLISDFKKSVSFWGKFVKLSEITNGidkNLISDKFLEEIKQTDIFLQK 824 Candida tropicalis MYA-3404
XP_003675123 751 -----TYksIPNLEEQFEISHEFLVQVSKVMQELTSv--GLLKKGDQNSFEQAVKFSEd 802 Naumovozyma castellii CBS 4309
CCD23435     769 -----TYksVPNLNEQFEHSYEYLMQILKVLKELNAi--GLFDRKDLKIVEEALEFCSN 820 Naumovozyma dairenensis CBS 421
XP_003959380 783 -----TYktIPDLGEQFENAVEYLTQCVNLVKELSSq--RLMKNDEAALIAKAVEFTKN 834 Kazachstania africana CBS 2517
CCK70425     765 -----TYkcVPNLTEQFDQSIAYLSQCKVLFDELCDm--KLVSKDESELLSEAVTFATN 816 Kazachstania naganishii CBS 8797
P40850       775 -----TYksTPNLDEQFVESHRFLLEISKVMQELNAa--KLIDENVFKLFTKAVEFTTT 826 Saccharomyces cerevisiae S288C
CCH61414     843 -----TYrsTPNLEGQFKNSLEFLEQVSSVFNELLKv--GLVTENNTKLLSNAVEFART 894 Tetrapisispora blattae CBS 6284
XP_002555402 746 -----TSkvVPNLDEELKRSLDFARQFGQVLGALSKa--NLCEKQDYELVVEAVEFAEK 797 Lachancea thermotolerans CBS 6340
XP_003646944 716 -----THkyVTNLAEELERASNYLKDVGVIFGSMKDl--KLINDADFELFNDALKFSNK 767 Eremothecium cymbalariae DBVPG#7215
Q755V4       715 -----AYkhVPNLEEEMKRALKYLENVKSLLGVMHAl--DLIQESEYELFNDAAAFANK 766 Eremothecium gossypii
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