Conserved Protein Domain Family
FXMRP1_C_core

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pfam12235: FXMRP1_C_core 
Fragile X-related 1 protein core C terminal
This domain family is found in eukaryotes, and is typically between 126 and 160 amino acids in length. The family is found in association with pfam05641, pfam00013. This family is the core C terminal region of the fragile X related 1 proteins FXR1P, FXR2 and FMR1. These different proteins have different regions at their very C-terminus. The Glutamine-arginine rich region facilitates protein interactions. This family contains two blocks of RGG repeats that bind to G-quartet sequences in a wide variety of mRNAs.
Statistics
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PSSM-Id: 403448
View PSSM: pfam12235
Aligned: 23 rows
Threshold Bit Score: 88.3008
Threshold Setting Gi: 321462329
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFX73353            358 HLAHLKEVEQLRMEKLEIDQQLRSI--HNSNLTSAPTFppprrIDR--GYSAE--------PDNGGNRDRgnMTRGRGRg 425 common w...
XP_002593122        376 HLAHLKEVEQLRIENLQIAEELRNAggGGGTYFP---------PPRerRYSTDytsdttesTSRGRGQMY---GRGRGRg 443 Florida ...
EFN82491            395 HLAHLKEVEQLRQEKLEIDQQLRSM--HGSTTGPMPNFppt-----rrGMVAGpeegvsgrGGRGG------QSRGRGS- 460 Jerdon's...
WGS:AAQB:GK12202-PA 374 HLSHLKEVEKLRQEKLEIDQQLRAI--QESSMGSTQNFpvsrrSER--GYSSDiesvrsmrGGGGAQR----GRRGRGGg 445 Drosophi...
1_pfamImport          1 HLNYLKEVDQLRLERLQIDEQLRQI--GASSRPP-PNR-----SDKdrGYIADesv-----glgRGGKPY--SARGRSR- 64 
XP_022539181        355 HLNYLKEVDQLRMERLQIDEQLRQI--GGGPRAP-PGR-----PEKekPFSADngm-----gpsRGGKPF--GRGGRGR- 418 Mexican ...
XP_011478776        364 HLNYLKEVDQLRMERLQIDEQLRQI--GGSGGGS-GPR-----NPKdkAYVFDngm--glgMGRGGGKPYsgGRGGRGR- 432 Japanese...
XP_023184799        390 HLNYLKEVDQLRLERLQIDEQLRQIggGGGGGGA-GPR-----NPKdkSYVFDngmgmgmgRGAGGGKPYvgGRGGRGR- 462 southern...
XP_015207210        358 HLNYLKEVDQLRLERLQIDEQLRQI--GGGSRPQ-AGR-----SDKdkGFVSDdgpg---vgpsRGGKPY--GSRGRGR- 423 spotted gar
CAG00680            395 HLNYLKEVDQLHLERLHIDEQLRQF--GGAGA---GPR-----MPKekHFLLDngv-------------dpgSGRGAGRg 451 spotted ...
EFX73353            426 g----gRGAPVSsvvmdnssGGSRLHSALSSKEGTPAES---------TAKNITHAGSSHSAAAsGPPHSRDqrNRY 489 common wate...
XP_002593122        444 g----sRGRGQGgrg---rpRRYQGSRNAVSENDRRHQD---------ELSDWSSAVTEDSMSEaSGVRGSRysgnr 504 Florida lan...
EFN82491            461 ------RGRAPTrhn-----------agLRRDTMDSSED---------RVRDLPPRGGHQGGAGnSGYMSGRqgRPT 511 Jerdon's ju...
WGS:AAQB:GK12202-PA 446 g----gGGSGGGgg----ggNGLNQRYQNNRRDDDDYNS-----------------------------RGDHqrDQQ 485 Drosophila ...
1_pfamImport         65 ------RGPSYTsg----skHNFHCNLMAASEFNTEAPDwlflfqsvtKLSFKRKVLEEKNINKnNSYLNKEp---- 127
XP_022539181        419 ------RGPTFA--------SGTNSEASNASETESDHRD---------ELSDWSLAPTDEE----SMGYPKRvsDGR 468 Mexican tetra
XP_011478776        433 ------RGAGASf------tSGTNSEASNASETESDHRD---------ELSDWSLAPTEELMTG-GGTLPRRt-DGR 486 Japanese me...
XP_023184799        463 ------RGGGAAf------tSGTNSEASNASETESDHRE---------ELSDWSLAPTEELMTG-GGSLPRRt-DGR 516 southern pl...
XP_015207210        424 ------RGPGFA--------SGTNSEASNASETESDHRD---------ELSDWSLAPTDEE----RDVFTRRg-DGR 472 spotted gar
CAG00680            452 hggggggGEAAMa-------sGTNSRASNASEASSEHKD---------ELSDWSLAATDEQAPG-SGVLPRRtdDRK 511 spotted gre...
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