Conserved Protein Domain Family
Rav1p_C

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pfam12234: Rav1p_C 
RAVE protein 1 C terminal
This domain family is found in eukaryotes, and is typically between 621 and 644 amino acids in length. This family is the C terminal region of the protein RAVE (regulator of the ATPase of vacuolar and endosomal membranes). Rav1p is involved in regulating the glucose dependent assembly and disassembly of vacuolar ATPase V1 and V0 subunits.
Statistics
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PSSM-Id: 403447
View PSSM: pfam12234
Aligned: 64 rows
Threshold Bit Score: 680.054
Threshold Setting Gi: 398404113
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6BYJ7        683 VKFFAINFAKSRDSLEWIETYRLH--TNISEATKIHGASIiNKFAIV---DKTGSRLTIWDTKSGVL----EYEETFdDS 753  Debaryomyces ...
XP_002171588  576 LQTWTATV-TSDNTPRVLELSRVQ--TSVRDATLIKGSTS-KIVAVV---SENGSRLSVFDMRSSEFssqeESSAVF-PE 647  Schizosacchar...
Q9Y817        576 LQTWMARV-LGDDKAEISEISKVQ--TSIKSATMIKGSTS-KKVAVV---SENNRRLSIFDTRSSEFsekeEFSSVF-DD 647  Schizosacchar...
EPY53766      577 LQTWIAKV-IEPFKASISEFSRLQ--TNIKSSSMVKGSTS-RKVAVV---SDNRLRLSIYDTRSSLFtsneEFTNVF-ND 648  Schizosacchar...
EIE80308       66 ilfYSMYITSDDASIEWNVLYTLDlpSSL-SIQHIRYCSP-NIVAVVs--GDNSTQLSIWTGMRAGIapvcEQKISF--- 138  Rhizopus dele...
EPB89763       42 peiifygINTDNTSIEWDALFSMDasSLASSIHQIK-CAP-GTIALVs--GQNRKTLSIWMEMRSGVapscVKTFEF--- 114  Mucor circine...
CBQ68202      654 ievrHAT-RDLSGELRWPVTATFD--ESTGTTRLARRSAN-GLVAVVtrdEQGKDTLVVFDSKTTSFnsgeEHRQTF-GS 728  Sporisorium r...
GAC99552      653 FEAMHAT-RDTRGQLRWTAVALLR--ESSGIPQRVRCNVD-GLFAAVtrdDQGTETLVIFDLKTSSFssgeEHRQSF-GA 727  Pseudozyma hu...
XP_011386551  656 IEAVHAI-QDATGQLRWTTIAAFH--EPLGTPTLISGSAH-GLVALVtrdKQEKETLVILDSKTSSFssgeEHRQCF-SS 730  Ustilago mayd...
SAM58489      659 VEVWKPT-GNSSNELHLDLVTSLR--PSAGSPQLVRCSAS-GLIAVVhhdEHDSQVLVIYNSKTTSFssgeEHRQTF-GS 733  Ustilago brom...
Q6BYJ7        754 YGAVTDLDWTFItsnserLTSNAILSVGFLRFVLLYTQLR-YDYTNK-----IPTFAVLKKIDISNYTSHEIGDLIWLDD 827  Debaryomyces ...
XP_002171588  648 LGPIIDLDWTST------PNSHSILAVSFKHDVVLICQNR-RSYIMK-----SPLWVPIVRVNTSSFTDLPIRDSTWLDN 715  Schizosacchar...
Q9Y817        648 YGPINDLDWTST------PNSHSILAVGFLHDVILLCQNR-RSYMND-----IPCWSRIRRYNLLEYTNSLISDSSWLDN 715  Schizosacchar...
EPY53766      649 YGPIIDLDWTST------PNSHSILAVGFQHEVILLCQNR-RSYISD-----APCWVPIRRYSLSMYTNMLISDSSWLDN 716  Schizosacchar...
EIE80308      139 DQSIKDIAWSVT------SDAQFILAVAFSDHISIYGQKRaYNNGYE------AEWSCYADFKVD--TPEDITALAWVDY 204  Rhizopus dele...
EPB89763      115 DEPVCDIAWNVT------SDAQFILAIAFPKSVSIFGQKRaSNNVNN-----DDIWACYTTFKVD--TPEDITALAWVDC 181  Mucor circine...
CBQ68202      729 DESIVAIDWSPS------PLSSSVLAVAFEHHVDIIAPGR-SSPNDArdagpGPQWQLLVRLDLRTCTPSSIRAACWLGS 801  Sporisorium r...
GAC99552      728 EESVVGLDWSPS------PLSSNMLAVAFHHHVDIVAPRR-FSPYEAhdattGSQWQLLVRLDLRSCTSSAIRAACWIGS 800  Pseudozyma hu...
XP_011386551  731 EEVVVALDWSPS------PLSSNVLAVAFEHHVDIVASRR-SSPFDLnqarsSPQWQLLVRLDLRICTPSMLRSACWLTC 803  Ustilago mayd...
SAM58489      734 RDRIIALDWSPS------PLSNNALAVVFEHHVDVMAPGR-ASTFDSksangGSRWEQLARLDLLSCTPSSIRAACWLGS 806  Ustilago brom...
Q6BYJ7        828 GYLVIGCGNQFFIDDKWVKLgssannsldstirqlmvgytniENEdyDSsqketksTYDmiYDIEQLVRILNGPLPVYHP 907  Debaryomyces ...
XP_002171588  716 GTLVLACGTGIYYFDKTLPQ---------------------------NPsllypysVNRqsKDLFDLVYQLNGILPVYHP 768  Schizosacchar...
Q9Y817        716 GTLVTAIGNGLFYFDNSLPE---------------------------DQsllfpasLKRsaKNIFDLAYQLNGILPVFHP 768  Schizosacchar...
EPY53766      717 GTLVTAAGNNLFFFKNKIPN---------------------------NKsllfpasLKRsaNNIFDLAYQLNGILPVFHP 769  Schizosacchar...
EIE80308      205 GVLTVAAGNQLRCYLKWLTE-----------------------QDtvIKssdslndKMEpmSSIYDISYEMNGPLPFYHP 261  Rhizopus dele...
EPB89763      182 GVLTVAAGNQLRCYLKWLID----------------------DETisKAvqvhgvsQVEpmSSIFDISYEMNGPLPFYHP 239  Mucor circine...
CBQ68202      802 EQLVIASGSVLFVYGPWLHSglq-------------------------------dvTRSrkMHLAELVAEVGGPVVQYHP 850  Sporisorium r...
GAC99552      801 EQLVIASGSLLFLYGPFVQPssq-------------------------------vaGEPkkVHLAELVAEVGGPVVQYHP 849  Pseudozyma hu...
XP_011386551  804 EQLVVASGSLLLIYGPWVQPclp-------------------------------ctEVPkdMHLAELVAEVGGPVVQYHP 852  Ustilago mayd...
SAM58489      807 EQLVVASGAVLFVYGPFVQSsls-------------------------------ngIGSerMHLAELVAEVGGPVVQYHP 855  Ustilago brom...
Q6BYJ7        908 QFLIQCLFMHQISLVKDVFVRLFQILRkgdSIQWDlsMDLTNEVLENNESRQ-----SGASTPSlsSKid--iiNDAFSS 980  Debaryomyces ...
XP_002171588  769 QFLQQLMLNNKISLILLILHRVYECLQq--------nNPLHFLLNIEAEKLIlpsaaQDDVQSQvnSVldeiksGNDSVE 840  Schizosacchar...
Q9Y817        769 QLLQQLLLRNQPFLFTNILLRFYLCLKd--------dVDMHFLLNMDCSEFY-----CCDEEISkdLLikslsqNSAEIL 835  Schizosacchar...
EPY53766      770 QFLQQLLLKNQEFLIRKILLLFYICLKn--------dYPMHFLLNMDCSDFY-----EHNDEKLmeKFfevlttYANEIp 836  Schizosacchar...
EIE80308      262 DHIIHYIMWGKMELVHNVFLTMYGFLK---QFVDEedNVMNELPPVSFSNML-----KLQDINGs-TKknkggyDVLFDN 332  Rhizopus dele...
EPB89763      240 DHLIHYIMWGKMDLVHSVLISLYTFFK---QFVDDedNIINEFPPVSFSKML-----KLQNGKS--SKsakqeyNGLFED 309  Mucor circine...
CBQ68202      851 TFLLQCAVWHKLGLAKAIIGNLNKAVL---ACSAQevGETWAFEDVPLDAVL-----EGDSTADnaASkhaaplPRKSFR 922  Sporisorium r...
GAC99552      850 AFLLQCAIWGKMEVAMAVISNLENAVL---AYDGQdtGDSWAFQEVPLDAVL-----LHDSAAGngRTrsa-lpSRHTVD 920  Pseudozyma hu...
XP_011386551  853 TFLLQCAIWGKIGLASAIIGNLEKALL---ACSAQdmGETWAFEEVSLDAML-----KDDRTADqgATklv-psTQKNTL 923  Ustilago mayd...
SAM58489      856 AFLLQCALWGKMGLAKAIISNLDKAAF---ACNAQdvLETWAFEQVPLDILL-----KDDAKADeaRPra---pQRHGVQ 924  Ustilago brom...
Q6BYJ7        981 Kf--------dSSGIHIFNSFNDNLLDLLIEKLMKISLPLLTRHQQITLISIISIVKELGKYLMSLDENGLRFLMGF--K 1050 Debaryomyces ...
XP_002171588  841 EtavnslnewrNS---------LDWLSSLEAQLKSQKVQTLTRTSQFLLLNFIEAFHKTLSVGSFLDLNGRRYCLML--N 909  Schizosacchar...
Q9Y817        836 Npael--dfeeTSVSKHLGLYIDEMIKKLTALLKVKKVKTLTRSSQFLLLNLIEAFNKARALRDSLDLNGKRYCIML--N 911  Schizosacchar...
EPY53766      837 vead--sfgekPSVSEDVTTYMNAFMTHLCLLLKNKKVGTLTRSSQFYLLNVIEAFDKAYHLRESLDLNGRRFCIML--N 912  Schizosacchar...
EIE80308      333 Gdete---gtdDEEDEEVRFMTSNEAKNLAHCLKHKNLPGLSKRDKYQLIAMVNTIVEITNQGESIDANGARFIALVenH 409  Rhizopus dele...
EPB89763      310 DddaedvdkkqDDDDDVVRALTSNEAKNLAHYLKVKVLPGLNENERIHLIAMVDTIVEITNQGESLDENGARFTALLenH 389  Mucor circine...
CBQ68202      923 Gsild--epdrTDEADEADLFASDRIDDLACRLKEIHPPHLSSSDLGMLVNLIKTIGEAVREHRSLDPSGLRYTLAL--R 998  Sporisorium r...
GAC99552      921 Gsifd--eldrSDDADDSGLFGLDRIDSLAQRIRDVQPPHLSPSDLDVLVNLVKSIGEVAREHRSLDPSGLRYTLAL--R 996  Pseudozyma hu...
XP_011386551  924 Ssifd--epasVGDARDTDLFAIDRINTLARHLQEIKPPHVSAADIEVLVCLIKTISEAIREHRSLDASGLRYTLAL--R 999  Ustilago mayd...
SAM58489      925 Rsifd--epdlSGDQADTDPFSSERIEKLVVQLKQVRPPHLSDSDLHMLVNLIKTIGEAVREHGSMDPSGLRYMFAL--R 1000 Ustilago brom...
Q6BYJ7       1051 LFQLSSK---------QSKLTTRDISWALHSDNKEMLLTMVEEYFKNRLKWENVKQIGLVYWVET-IRLTKIMESCARNE 1120 Debaryomyces ...
XP_002171588  910 QYTLLRHqt-----keKSQLPFRDCMWAFYSSNQDVLLGYSKQLLGNFLLWDDVRELGLPYWLSQ-SSLCQVFRELAQNH 983  Schizosacchar...
Q9Y817        912 QYVLSKHqr------qLTSLPTREMAWAFHSSNKAVLLDHTKKLHGKPLLWNAVEEYAIPFWLNE-QLLKDVFLELSRNH 984  Schizosacchar...
EPY53766      913 QYVLNKYqr------rSNRLPTRDILWGFYSTNKSVLLDYTVKVHGKTLLWPVVEEYGLPFWLNQ-QALINVFGELSRNH 985  Schizosacchar...
EIE80308      410 FHLNLQLpee----qrQPNLQTRDFTWALHSQSQDLLLQKCMQLCGDKFVWEDARSLGIFLWLQKiDTVREQMTTIARNI 485  Rhizopus dele...
EPB89763      390 FHLNKSLppe----qrQMQLESRDYVWALHSQSQDLLLERCIRLCDNKLVWEDARNLGLFIWLQKiDVVRDQMATIARNI 465  Mucor circine...
CBQ68202      999 QMLNGTSeskevkvapHAGLGYRDFLWAFHSNNQETLLAAIESAYRNKLDWPAARATGLFVWLQNpSALRAQAEAVARAQ 1078 Sporisorium r...
GAC99552      997 QMLNRTDmskqaknapSIELTYRDYLWAFHSDNQETLLAYVESAYPNKLDWRAARSAGLFTWLKNpSALRTQAEAVARAQ 1076 Pseudozyma hu...
XP_011386551 1000 QMLNRSSpwkqakqasAVSLTYRDYLWAFHSHNQETLLSSIESVYHNQLDWPAARATGLFIWLQNpSMLRNQAEAVARAQ 1079 Ustilago mayd...
SAM58489     1001 QTLNGSDpvkdaqatpVAELSYRDFLWAFHSDNQETLLSAVESSYRNKLDWPAARSTGLFAWLKSpQALRTQAEAVARAQ 1080 Ustilago brom...
Q6BYJ7       1121 FS----DTRDPSgRVSLFYLAIRKKQVLIGLWRTVS-HTEQQKMLKFLANDFNESRWKSAALKNAYVLMGKHRYIDAAYF 1195 Debaryomyces ...
XP_002171588  984 YTh--nDERNPE-FVSLYYMALRKKAVLVNLWKLASwHKESARTVKLLSNDFTLPRWRVAAAKNAFALLSRHRYFYAAAF 1060 Schizosacchar...
Q9Y817        985 YAe--iDDRNPE-NVSLYHIALHKINVFRDLWRLASwHKESARTVKLLSNDFSKKKWKVVASKNAFALLSKHRYFYASAF 1061 Schizosacchar...
EPY53766      986 YIn--nGERDPE-KVSLYHVALGKVAVLRSLWSLASwHKESGPTVKFLSNDFTQKRWKVAASKNAFALLSKHRYFYAAAF 1062 Schizosacchar...
EIE80308      486 YLsk-eDFRDPV-DCTLFYFALRKKNLVQGLWRSASyHKEQGAMLKFLANDFSQPRWQTAASKNAFALLGKQRFEYAAAF 563  Rhizopus dele...
EPB89763      466 YLsksaEARDPV-DCTLFYLALRKKNLIEGLWKSTSsHKEQAAMKKFLANDFTDPRWQRAASKNAFALLGKQRFEYAAAF 544  Mucor circine...
CBQ68202     1079 FMs--gEDRDPV-KCSLLYFALGKRKVVQGLWRQAVwHPEQKKMLQFLSHDFDEERWKTAAQKNAFALLSQRRYEFAASF 1155 Sporisorium r...
GAC99552     1077 FMs--sEDRDPV-KCSLLYSALGKRKVVQGLWRQAVwHPEQKKMLQFLSHDFDEQRWKTAAQKNAFALLSQRRYEFAASF 1153 Pseudozyma hu...
XP_011386551 1080 FMs--sEDRDPV-KCSLLYFALGKRKVVQGLWRQAVwHPEQKKMLQFLSHDFDEQRWKTAAQKNAFALLSQRRYEFAASF 1156 Ustilago mayd...
SAM58489     1081 FMt--gEDRDPV-KCSLLYFALGKRKVVQGLWRQAVwHPEQKKMLQFLLHDFDEERWKTAACKNAFALLSQRRYEFAASF 1157 Ustilago brom...
Q6BYJ7       1196 FLLADALKDCCNIIATKLNDVQLAIAIAKIYSAtskgtiSEGEIIKNLIENYMVPEVLKNGDRWITSWIFWELEEHEISI 1275 Debaryomyces ...
XP_002171588 1061 FLLGDQCLDAVRVCIRNLNDPALAIAVARVYEG------DDGPTFSKLLVEFMLPISQRYYDRFLACWCFEMLKNKAKAI 1134 Schizosacchar...
Q9Y817       1062 FLLADSCYDAAKVCIRNLKSISLAIAMTRVYEG------DDGPTLKRLINEYVLPLAVSQNDRWLTNWSFTILKQEKKAL 1135 Schizosacchar...
EPY53766     1063 FLLADSPYDAAKVCIRNLRCLSLAVAVVRVYEG------DGKTCLKRIIEEFVLPSAAYHNDRWLTNWGFAMINEKMKSV 1136 Schizosacchar...
EIE80308      564 FLLADKLRDAVNVILRNVKDYQLAIAICRVYEG------DHSPILREILENTVIPTAIKSNDRWLISMTYWLLGKQKESI 637  Rhizopus dele...
EPB89763      545 FLLADKLKDAVNVILKNVKDFHLAIAICRVYEG------DHSPLLREILENSVIPMAIENNDRWLISMAYWLLDKHKDAV 618  Mucor circine...
CBQ68202     1156 FMLGESLRDAINVCVRNLDDLPLAIALARIQEGr-----DDGPVFTELLKNRVLPLAFERGDRWMGSWAFWMLKRRDLAV 1230 Sporisorium r...
GAC99552     1154 FMLGESLRDAVNVCVRNLDDLPLAIALARIKEGc-----DDGPVLTDLLKTRVLPLAFERGDRWMGSWAFWMLKRRDLAV 1228 Pseudozyma hu...
XP_011386551 1157 FMLGESLRDAVNVCVRNLDDLPLAIALARIHEGr-----DDGPVLIDILKTRVLPLAFETGDRWMGSWAFWMLKRRDLAV 1231 Ustilago mayd...
SAM58489     1158 FMLGESLRDAVNVCVRNMDDLPLAIALARVKEGc-----DDGPVFTDLLRTRVLPLAFERGDRWMGSWAFWMLKRRDLAV 1232 Ustilago brom...
Q6BYJ7       1276 QALIKSPIEIINhHkakf-sddCSKNyiski--------tprfSSMSFLK----------DDPVLIILFHALRQ------ 1330 Debaryomyces ...
XP_002171588 1135 QCLVSPLYSTIRdDaelkkettATATllprddd----alpghpQDKNGAA----------DDPALILLYVWLRDqfctfg 1200 Schizosacchar...
Q9Y817       1136 QSLVSPIRSLVSdNdfiqlytsDKNDqeihenkdsqrnstnepVRNKFPS----------DDPAFILLYECLRS------ 1199 Schizosacchar...
EPY53766     1137 QSLLVPVRSLIEvDndliesfgIIGDypletet---teenhdkTKNEYTS----------DDPALILLYDFLRS------ 1197 Schizosacchar...
EIE80308      638 RSLIVPLSQFTDeLihdedsaaAV------------------------------------QDPNAFILYHQLKK------ 675  Rhizopus dele...
EPB89763      619 RAMVVPLTQFTDkDidttdadfAAVV----------------------------------HDPNAFILYQHLKK------ 658  Mucor circine...
CBQ68202     1231 RIIVTPLRDLIAdA-----------------------------DVASLLGapvtcgndsySDPALALLFQHLRT------ 1275 Sporisorium r...
GAC99552     1229 RIIVTPLRDLIAdK-----------------------------DVASLLGstltcgndsyGDPALALLFQQLRS------ 1273 Pseudozyma hu...
XP_011386551 1232 RIIVTPLRDLLAdK-----------------------------DVAVLIGssitcgndsySDPSLALLFQQLRA------ 1276 Ustilago mayd...
SAM58489     1233 RIIVTPLRDLLAdE-----------------------------GVASLLGsnvtcgndsyNDPALALLFQQLRS------ 1277 Ustilago brom...
Q6BYJ7       1331 ---KTIKYLKGSLSIAPDEEFNFIIKVCSIYTRMGCDYLAVV 1369 Debaryomyces hansenii
XP_002171588 1201 gsaSQLRPLGNLAPVNPSHEFKFVLHMARVYDQMGCDLTALS 1242 Schizosaccharomyces japonicus yFS275
Q9Y817       1200 ----------SNVQIDESLEYRFVLHNANVYCQLGCDLIALG 1231 Schizosaccharomyces pombe 972h-
EPY53766     1198 ----------DLLRKDQILEYRFVLNSARVYNEMGCDLIALD 1229 Schizosaccharomyces cryophilus OY26
EIE80308      676 ---GQTQVLS----VPYDLEYHFSLLVSKAYERLGCPLLALH 710  Rhizopus delemar RA 99-880
EPB89763      659 ---SLIQDQK--SIVSYSIEYGFSLLVSRSYERLGCPLLALy 695  Mucor circinelloides f. circinelloides 1006PhL
CBQ68202     1276 ---KSLQTIKGLYGIPEKKVFDFVLTTNRALCRMGCDAIGLS 1314 Sporisorium reilianum SRZ2
GAC99552     1274 ---KSLQTIKGLYDIPEKKVFDFVLNTNRALCRMGCHSIGLS 1312 Pseudozyma hubeiensis SY62
XP_011386551 1277 ---KSLQTIKGLYDIPEKKVFDFVLNTNRGLCRMGCHSIGLS 1315 Ustilago maydis 521
SAM58489     1278 ---KSLQTIKGLYHIPEKKIFDFVLNTNRALCRMGCHSIGLS 1316 Ustilago bromivora
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