5NW5


Conserved Protein Domain Family
Rif1_N

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pfam12231: Rif1_N 
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Rap1-interacting factor 1 N terminal
This domain family is found in eukaryotes, and is typically between 135 and 146 amino acids in length. Rif1 is a protein which interacts with Rap1 to regulate telomere length. Interaction with telomeres limits their length. The N terminal region contains many HEAT- and ARMADILLO- type repeats. These are helical folds which form extended curved proteins or RNA interface surfaces.
Statistics
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PSSM-Id: 403445
View PSSM: pfam12231
Aligned: 67 rows
Threshold Bit Score: 206.71
Threshold Setting Gi: 1208077154
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5NW5_B        146 TFNNIIPILTTKN----VNEvdQKFNILIVNIEsiieiciphlqiaQDTLlSSSEKKNPfviR-----------LYVQIV 210  Saccharomyces...
XP_002110766   63 AYLTLTERLRHDDqdilVDEicRNATILCSVVK-------------RDILsDPRE-------------------LALASL 110  Trichoplax ad...
E1C2U2         31 AHLSLVNRLSGEEgrefVAAvrKHFPRLCKVFK-------------AHISsENSE-------------------LSNAAL 78   chicken
Q5UIP0         29 AYLTLTSRMTGEEgkevITEieKKLPRLYKVLK-------------THISsQNSE-------------------LSSAAL 76   human
XP_014352365   31 AYLTIANRLSGEEgkqfVAVveKHFSRLCKTFK-------------GNISsGNLE-------------------LSNAAL 78   coelacanth
XP_005475278   33 AYLTIANRLSGEEgrqfLPAveKHFSRLGKAIL-------------AHIIsPNAE-------------------LSQAAL 80   Nile tilapia
XP_007253540   32 AYLTIANRLSGEDgrqfFPIivKHFSRLGKSLQ-------------THISsENEE-------------------LSQAAL 79   Mexican tetra
XP_005167632   32 AYITIANRLNGEEgrqfLPVvvKHFARLSKVLL-------------VHISsENEE-------------------LCQAAL 79   zebrafish
Q54JQ5         58 ENGMVISVLSNSDialrFINifQTHIICCNNNQstplpnlklknnnNNNNnNNNNNNNNnngNnnsilnnqidkLAINSL 137  Dictyostelium...
XP_004356223   24 AFNQLLGLLKEHv---eNDTisQSFKLTPQTITtyikiyqyyisssNNNQpSSDN-------------------LAISSL 81   Cavenderia fa...
5NW5_B        211 RFFSAIMSNFKIVKWLTKrpdlvNKLKVIYRWTTGALRNENSNKIIITAQVSFLRDEKFGTFFLSNEEIKPIISTFTEIM 290  Saccharomyces...
XP_002110766  111 QALGYCFSLP-------------DDVAIGMLKALCSAIVSTHDKNRCTRALWCVAKQNINSDIVAN-QVSVVLPALEHVL 176  Trichoplax ad...
E1C2U2         79 QALGFCVFNSKITSELS------ASEVEDLLSTLNSIAVKTSDKNTRTRALWVISKQTFPSEIIKK-EVSSLISTLETIL 151  chicken
Q5UIP0         77 QALGFCLYNPKITSELS------EANALELLSKLND-TIKNSDKNVRTRALWVISKQTFPSEVVGK-MVSSIIDSLEILF 148  human
XP_014352365   79 QALGFCVFHSNVASGLA------ASEVEELLSVLSSIAAVTSDKNTCTRALWVISKQSFSPEVVGK-KVPSIVSTVETLI 151  coelacanth
XP_005475278   81 QALGFCVYHSHVVSGVS------EVFAAEILSALCSLVSKATDKNTCTRALWVISKQSFPAEEVAK-KVPSILGTLESVW 153  Nile tilapia
XP_007253540   80 QALGFCVFNTNIVSGIP------AHFAEEILLALCALVLKSTDKNTCTRALWVISKQNFPAEVVSK-KTPEILKTLDAMQ 152  Mexican tetra
XP_005167632   80 QALGFCVFHSHIVSVIP------ANISENILSTLCNVVVKSKEKFTCTRALWVISKQNFPPEVASK-MAPEILKSLEAMQ 152  zebrafish
Q54JQ5        138 RSLGFFLYSSSIIKCLSS-----DTQIREISTLLENTIQVTKNKNICNYAIWCFSSQSFPNGPISNKLPNTYCDLLENTP 212  Dictyostelium...
XP_004356223   82 RCLGYFIYSKFIVGHLL------ENQIKDISILLENTISTTKNKNICNFAVWCLTSQAFPNGPISTKLAKTYCNILETVP 155  Cavenderia fa...
5NW5_B        291 ---EINSHNLIYEKLLLIRGFLSKYPKLMIETVTsWLPgevlpriiigdeiysmkiliTSIVVLLELLKkcldfvDEHER 367  Saccharomyces...
XP_002110766  177 lsgGFQSATVEFEAMNVILRLIEQVPNTMRANVAkWGI--------------------LVYPVMLNSAV------KVAER 230  Trichoplax ad...
E1C2U2        152 tkgDVQSMIVEYEALNVVIRLMEQAPAQMGEEAVrWAK--------------------LIIPLVVHSAH------KVQLR 205  chicken
Q5UIP0        149 nkgETHSAVVDFEALNVIVRLIEQAPIQMGEEAVrWAK--------------------LVIPLVVHSAQ------KVHLR 202  human
XP_014352365  152 tkgDVQSLVIEHEALNVVIRLLEQTPIQMREDAVrWAK--------------------VVIPLVVHSAH------KVRLK 205  coelacanth
XP_005475278  154 kreDIHSVVMEHEALNVIIRMLEQVPTQMGEGAVqWAK--------------------LVIPLVVHSAS------KVRLR 207  Nile tilapia
XP_007253540  153 t-rDIQSILMEHESLNVVIKLLDQAPTQMGQGAVfWAK--------------------LVIPLVVHSAS------KVRLR 205  Mexican tetra
XP_005167632  153 t-rEVQSILIDHESLNVIIRLLEQAPVPMAVGAVcWAK--------------------LVIPLVVHSAN------KVRLR 205  zebrafish
Q54JQ5        213 ----FNSKTIENEVLNSFTTLLQQNIQLYLNSTEiWLP--------------------IIFNKILRLENl----pNITEK 264  Dictyostelium...
XP_004356223  156 ----FGSPTIEREVLLSFTHIYAQNPQIFLPMAHkWIP--------------------LLFDKMLANSStsgdvgKLSEE 211  Cavenderia fa...
5NW5_B        368 IYQcIMLSPVCETIPEKFLSKLPLNSYDSANldkvtigHLLTQQIKNYIVVkNDNKIAMDLWLSMTGLLYDSGKRvydlT 447  Saccharomyces...
XP_002110766  231 ALVvMESALPLLLSSQEELIRVLIPDLKANL----------IDEMGKMMAE-RREISALRAWRYYIILLGKVLHR----S 295  Trichoplax ad...
E1C2U2        206 GATaLEIGMPLLLQKQQEVAAVTEHLMTTKL----------ISELQKLFST-KNETYVLKLWPLFVKLLGKTLHR----S 270  chicken
Q5UIP0        203 GATaLEMGMPLLLQKQQEIASITEQLMTTKL----------ISELQKLFMS-KNETYVLKLWPLFVKLLGRTLHR----S 267  human
XP_014352365  206 AATaLEMGMPLLLQKQQEVASITEQLMTTKL----------IPELQKLFST-KNETFVLKLWPLFVRLLGKSLHR----G 270  coelacanth
XP_005475278  208 AAAaMEMGMPLLLEKQNEVSAVIEPMMSTKL----------IPELQKLFMS-KNETNVLKLWPLFVKLLGKLLHR----G 272  Nile tilapia
XP_007253540  206 AAAaLEMGLPLLLEKQQEVAAIVEPMMSTKL----------IPEMQKLFST-KNESNVLKLWPLFVKLLGKLLHK----G 270  Mexican tetra
XP_005167632  206 AAAaLELGMPLLLEKQQEVAAIVEPMMSSVL----------IPEMQKLFAS-KNETNMLKLWPLFVRLLGKLLHK----G 270  zebrafish
Q54JQ5        265 LKQiLEIVVNHYQMKNNVMSERVSEVLLSNC-------NSFMENMGKLFDT-KNEILSIQCWGIYVFFTGKLIF-----V 331  Dictyostelium...
XP_004356223  212 MIKrLILPAPPHELFAPEVYKELTQGLIQEI-------DVFISKLTSLND--KNELHCATIWGYFIYFLGEELFS----- 277  Cavenderia fa...
5NW5_B        448 SESNKVWFDLNNLCFINNH-PKTRLMSIKVWRIIT--YCICTKISQKNQegnksLLSLLRTPF--------QMTlpyvnd 516  Saccharomyces...
XP_002110766  296 GSLLNDMLKIMEMGFKNKS-IDILLEAYANWRHFIdsFVSYTDLTTSPK-----KRKLLSTPImiksse----------- 358  Trichoplax ad...
E1C2U2        271 GSFINSLLQLEELGFRSGS-PVVKKIAFIAWKSLIdnFALNPDILCSAK-----RLKLLMQPL----------Ssihv-- 332  chicken
Q5UIP0        268 GSFINSLLQLEELGFRSGA-PMIKKIAFIAWKSLIdnFALNPDILCSAK-----RLKLLMQPLssihv------------ 329  human
XP_014352365  271 GSFINSLLHLEELGFRSGS-PVVKKIAFIAWKSLIdnFALNPDILCSSK-----RLRLLMQPLssihv------------ 332  coelacanth
XP_005475278  273 GPFINSLLHLEELGFRSSS-PTIKKIAFLAWKSLIdnFALNPDILCSAK-----RMKLLMQPLtsinv------------ 334  Nile tilapia
XP_007253540  271 GAFINSLLYLEELGFRSSS-PNIKKIAFLAWKSLIdnFALNPEILCSSK-----RLKLLMQPL----------Ssilv-- 332  Mexican tetra
XP_005167632  271 GAFINSLLYLEELGFRNSS-PNIKKIAFIAWKSLIdnFALNPDILCSSK-----RLKLLMQPLssiqv------------ 332  zebrafish
Q54JQ5        332 NKMANKVLGLAEKCFTHEN-KLVRIETYNSWKLLI--DSMDIEYISVDK-----RLELFCAPFmtgftserEAE------ 397  Dictyostelium...
XP_004356223  278 NSIINKILKLPEKWFVCLEnPELRCQTFISWRYLI--DALRQKSLVIPK-----RLNLIATPLslglkretNSN------ 344  Cavenderia fa...
5NW5_B        517 psaregIIYHLLGVVYTAFTSNKnlstDMFELFWDHLI 554  Saccharomyces cerevisiae S288C
XP_002110766  359 -dtppvLNESRILTWWHLIKSMN----KHSPALFKEIC 391  Trichoplax adhaerens
E1C2U2        333 --rteaLALTKLEVWWYLLMRLG----PQLPANFEQVC 364  chicken
Q5UIP0        330 --rtetLALTKLEVWWYLLMRLG----PHLPANFEQVC 361  human
XP_014352365  333 --rteaMALTKLEVWWYLIIRLG----AQLPVNFEQVC 364  coelacanth
XP_005475278  335 --rteaLLLTKVEVWWYLVIQLG----PNLSPNFDQVS 366  Nile tilapia
XP_007253540  333 --rteaLLLTKLEVWWYLVVKLG----PNLATNFEQVA 364  Mexican tetra
XP_005167632  333 --rteaLLLTKLEVWWYLAVKLG----PNLSANFEQVG 364  zebrafish
Q54JQ5        398 ------VKKTSFSTWMYFLKQFK----TQLFDVFNKVF 425  Dictyostelium discoideum AX4
XP_004356223  345 ------VKLNCFITWLYLLNALG----GDLPNTFHIVA 372  Cavenderia fasciculata
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