6BJC


Conserved Protein Domain Family
TPX2_importin

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pfam12214: TPX2_importin 
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Cell cycle regulated microtubule associated protein
This domain is found in eukaryotes. This domain is typically between 127 to 182 amino acids in length. This domain is found associated with pfam06886. This domain is found in the protein TPX2 (a.k.a p100) which is involved in cell cycling. It is only expressed between the start of the S phase and completion of cytokinesis. The microtubule-associated protein TPX2 has been reported to be crucial for mitotic spindle formation. This domain is close to the C terminal of TPX2. The protein importin alpha regulates the activity of TPX2 by binding to the nuclear localization signal in this domain.
Statistics
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PSSM-Id: 403435
View PSSM: pfam12214
Aligned: 33 rows
Threshold Bit Score: 113.918
Threshold Setting Gi: 75111052
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6BJC_P       367 PQTPVLQTKHRARAVTCKSTAELEAEeLEK-----LQqyKFKARELDPRILEGGPIL-PKKPPVKPPTEPIGFDLEIEKR 440
2_pfamImport   6 PREPELETARRAFSFRAQRQRLVDAKcLVEgmpqfTS--TFKAHPLNRKILEAPSLP-LPQKSTPRLPKFKEFNFRTHSR 82 
F4I2H7       320 PKEPEFVTSQRARPLRVKSSAELEEEmLAK-----IP--KFKARPVNKKILAAPALP-APQRSTPHLPEFQEFHLQTMAR 391 thale cress
XP_009413368 382 PKNPEFETAHRVRAVRIKSSAELEEEmLAK-----IP--KFKARPLNKKIFEAPSFP-ALPKSVPQPPIFQEFHLKTMDR 453 wild Malaysian ...
XP_009406514 376 PKDPELGTAHRARAVRIKSSAELEEEmLSK-----IP--KFKARPLNKKILEAPTFP-ALPRSIPQPPVFQEFRLKTMER 447 wild Malaysian ...
XP_006351941 307 PKEPEFETAQRVRPTRVKSSAELEEEmMAK-----IP--KFKAHPVNKKILEAPTQPlLLPKSTPQLPEFKEFHLETMAR 379 potato
XP_010327080 412 PKEPEFVTAQRVRPTRVKSSAEQEEEmMAK-----IP--KFKARPLNKKILEVPTLP-TLPKSIPQLPEFKEFHLQTMAR 483 tomato
ERN19493     318 PREPELETAQRARRIMIKKNSDAGEGmLLM-----AP--KFKARPLNRKIFEAPSVP-LPQKSIPRVPEFREFHLKTTER 389 Amborella trich...
KRH77444     251 PREPDLETAHRAQRIRPKIAAEAEVV-TVA-----AP--IFRARPLNRKILNAPSLP-LPKRSTPRLPEFQEFHLKTQER 321 soybean
EMS46329     319 PKEPEFQTTHRVRAVRMKSSSELEEEmLAK-----IP--KFRARPFNKKIAEAPSFP-PLPRTAPQLPEFNEFHLKTMER 390 Triticum urartu
6BJC_P       441 IQERESKKKTE----------------------------------------------De-------HFEFHSRPCPTKIL 467
2_pfamImport  83 ALLHSTTSSTLvgsinldfcslmksctvhiliqy-qyigslrpnclinlkmnvehecKrdaevkdiSTKFRPQALNQKIL 161
F4I2H7       392 ANQHAETSSIAstevskqhndqkhhltepk--------spvlqtmlrarptiakttaEleqeelekAPKFKAKPLNKKIF 463 thale cress
XP_009413368 454 ANQHTETSSVVssidgsvqnqnkpfrltepr-------pphletslrarppmikstqEleledlekIPKFKARPLNKKIL 526 wild Malaysian ...
XP_009406514 448 ANQHAETSSAVssldgvvqnqvkpirltepr-------pphletsfrarpsknkssqEseleelekIPKFKARPLNKKIL 520 wild Malaysian ...
XP_006351941 380 ANKNVDTTSVQsiesssqshqwqphltapk--------spvlktslrarppiaksteElekeelekAPKFRARPLNKKIL 451 potato
XP_010327080 484 ANQNAETSTVAsiestqihqwksshltapk--------spvlktslrarpprirsskEmekeelekVPKFKARPLNKKIF 555 tomato
ERN19493     390 AIQHAAAAPSLpshvdsnnvankhkhassnqvgtidlkmschqaphlekhkvvdepkQeqr---erIATFKARPLNPKIL 466 Amborella trich...
KRH77444     322 AMQHTSATSTSslhcndsdkdldkhravsa---------qenrirdlrrpsamgapkHdgl---dfAHSFKARPLNKKIL 389 soybean
EMS46329     391 ASRHADTCSEAssvgtmrsqgskplklaeak-------ppqletalrarpsrvkstqEleleelekAPKFKAKPLNKKIL 463 Triticum urartu
6BJC_P       468 E--DVVGVPEKKVLPITVPKSPAF 489
2_pfamImport 162 AskGDIGVFRSTKRDTTIPKEFNF 185
F4I2H7       464 EskGEMGIFCNTKKHITIPQEFHF 487 thale cress
XP_009413368 527 EskGEIGLFCNPKPQITITEEFHF 550 wild Malaysian banana
XP_009406514 521 EskREIGMFCNPKPQKTIPQEFHF 544 wild Malaysian banana
XP_006351941 452 EskGDLGMFCNTKRQVTVPQEFHF 475 potato
XP_010327080 556 EskGDLGMFCNTKRQVTEPQEFHF 579 tomato
ERN19493     467 SskGDIGMFKNCKREATKPTEFSF 490 Amborella trichopoda
KRH77444     390 SskGDIGVFRNRKQETTVPMEFNF 413 soybean
EMS46329     464 EskGDIGVFAHPKAQATEPKEFHF 487 Triticum urartu
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