2JX0


Conserved Protein Domain Family
GIT1_C

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pfam12205: GIT1_C 
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G protein-coupled receptor kinase-interacting protein 1 C term
This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with pfam01412, pfam00023, pfam08518. GIT1 plays an important role in cell adhesion, motility, cytoskeletal remodeling and membrane trafficking. To perform this function, it localizes p21-activated kinase (PAK) and PAK-interactive exchange factor to focal adhesions. Its activation is regulated by interaction between its paxillin-binding C terminal and the LD motifs of paxillin. The C terminal folds into a four helix bundle.
Statistics
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PSSM-Id: 403431
View PSSM: pfam12205
Aligned: 19 rows
Threshold Bit Score: 154.785
Threshold Setting Gi: 1005951418
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2JX0_A               13 LPSTEDVILKTEQVTKNIQELLRAAQ---E-FKHDSFVPCSEKIHLAVTEMASLFP---KRPALEPVRSs-------LRL 78 
WGS:AAPU:GI20174-PA 614 KPFGEEVKLRSDLVTRCLKELIQAMHpatE-AEKQSIAPHGERIRSAVTDLIALYSnlpPNASELTRET--------LKQ 684 Drosophi...
EDW47289            572 KPFGEEVKVRSDLVTRRLKELIRAMQpvpE-DQKQSIAPHGELIRSAVTDLIALYAnlpPNPNDPSRET--------LKL 642 Drosophi...
WGS:AAQB:GK10671-PA 606 KPFGEEVKLKSDLVTRRLKELIIAMQqgpE-EQKQSIAPHGERIRSAVTDLIALYTnlpPNASEATRET--------LKQ 676 Drosophi...
Q16UB2              560 LPLFDEVKNRTDLVARRIKELFAAMQ---DlAKTDAFVPCAERIRLAVAELIAIFP---ATMREETLRNa-------LKQ 626 yellow f...
XP_009027781        653 MPSQEEVVRKTERITKALQELFQMAQ---D-NSYNAYSGCSDRIQGAVTDMMQLFP---SAKMMTSVSQle-----aLRM 720 Helobdel...
EFX84315            582 ptTSDEVVRRTNIITKRIQEVFHNVQ---N-RRHDQVEPCAQRIVEAVQSMATIVP----QGSSEEVKTc-------INQ 646 common w...
Q1RLG9              632 LQRYDEVIRKTETVTRNISSLLQAAQ---K-GKSESYPACAENILTVVQEIVALFP---EDLNDPDMKNv-------IIK 697 vase tun...
2_pfamImport          2 LPKADEVIRKTDTVTKNISNLLQAAQ---K-GKSESYPECAENIYTAVQEIVALFP---DDQNDPDMKIv-------LDK 67 
XP_015784059        645 FPIKEDVFRKTEQITKGIQELLQVSL---E-GRQEVFIKCAENIQQAVFNMIDLFP---ESLSDGELKNkeeqlfeiIEA 717 two-spot...
2JX0_A               79 LNASAYRLQSECRKTVpP--------EPGAPVDFQLLTQQVIQCAYDIAKAAKQLV 126
WGS:AAPU:GI20174-PA 685 LTRNNILIQHECENLQ-Ks------iEAEDQQGIHKNMLEVRDCAFHIASAIKTLV 733 Drosophila mojavensis
EDW47289            643 LTRQNILIQHECENLQ-Ka------iDADDKQAIQKNTLEVRDCAFHIASAIKTLV 691 Drosophila sechellia
WGS:AAQB:GK10671-PA 677 LTRHNILIQHECENLQ-Ks------iETDDKLGIQKNTLEVRDCAFHIASAIKTLV 725 Drosophila willistoni
Q16UB2              627 LNFNTNLIHTECTRLQ-RsfveegshqSVLSDSIKLNMEQVRNCAYDLAMSTKILI 681 yellow fever mosquito
XP_009027781        721 LEEGSERIRELCCRVP-Q----------DSPADAKLHTQKIIQTAYDIAKAAKKLV 765 Helobdella robusta
EFX84315            647 LTTSAFRLLAECHEAG-T---------VASCPPDQAVTQRIIQGAYDVAKATKQLV 692 common water flea
Q1RLG9              698 LGGGAEKLRNRCKEVA-E---------QGIAFNAKQVTEEIIKNAYDIAKAEKELV 743 vase tunicate
2_pfamImport         68 LNSGADKLRNRCREVA-E---------QGIA-NSKQVTEDIIKNAYGIAKAEKELV 112
XP_015784059        718 LRNNTTRLMSECQVRN-S------------KPDGHSEVEKIIDSAYDIARVAKQLI 760 two-spotted spider mite
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