Conserved Protein Domain Family
IKKbetaNEMObind

?
pfam12179: IKKbetaNEMObind 
I-kappa-kinase-beta NEMO binding domain
This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with pfam00069. These proteins are involved in inflammatory reactions. They cause release of NF-kappa-B into the nucleus of inflammatory cells and upregulation of transcription of proinflammatory cytokines. They perform this function by phosphorylating I-kappa-B proteins which are targeted for degradation to release NF-kappa-B. This kinase (I-kappa-kinase-beta) is found in association with IKK-alpha and NEMO (NF-kappa-B essential modulator). This domain is the binding site of IKK-beta for NEMO.
Statistics
?
PSSM-Id: 403417
View PSSM: pfam12179
Aligned: 23 rows
Threshold Bit Score: 41.9059
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_006097115 708 LMAEAHNLCTQLESAMQD----TMKEQDRSLRSLDWSWL 742 little brown bat
XP_005048073 695 VIRENVNYLELFSSILQE----MRQEL-NSMMSFDWSWL 728 Collared flycatcher
Q5ZJB4       724 VIEENLNYLDRFSSMLQE----AREEQNNSLTNFDWSWL 758 chicken
XP_015201935 713 LLEENQMYLSQLTSLMQE----TTEEQVKSIMDQDWSWT 747 spotted gar
XP_011601695 689 LLEENENYLSQLTSLLQE----TTRDPEYSIMEQDWSWT 723 torafugu
XP_003441159 688 LLDENQRYLSQLTSLLQD----ATQEMEHSIMDQDWSWT 722 Nile tilapia
XP_005811961 689 LLDENQRYLNHLTSLMQD----ATQELKQSVMDQDWSWv 723 southern platyfish
Q4G3H4       712 LLEENQRYLTQLTSLLQE----TTEEKSESIMAQDWSWT 746 zebrafish
XP_003961166 714 LLQENQRYLSQLTSLMQE----AADEQSKSIVDQDWSWT 748 torafugu
CAG03014     831 LLQENQRYLSQLTSLMQEgcgrTVQKhfrgefksmraw- 868 spotted green pufferfish
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap