Conserved Protein Domain Family

pfam12171: zf-C2H2_jaz 
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Zinc-finger double-stranded RNA-binding
This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.
PSSM-Id: 403410
View PSSM: pfam12171
Aligned: 114 rows
Threshold Bit Score: 29.0465
Threshold Setting Gi: 75337315
Created: 21-May-2020
Updated: 7-Aug-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
6G90_T       280 IYCPFCSRWFKTSSVFESHLVGKIHK 305 baker's yeast
Q4DXJ0        68 FACKLCKKTFHSVQTLQAHVRSTAHL 93  Trypanosoma cruzi
Q16M83        54 LTCILCNSVVRSEAVWKVHINSKQHK 79  yellow fever mosquito
CAF98476      46 lSCVLCNVQVKSELLWPTHVLGKPHK 71  spotted green pufferfish
XP_001708492  28 LRCTLCDLAFKDSLTLVQHLSSEAHR 53  Giardia lamblia ATCC 50803
Q54VV0        97 FYCDVCDVSFKDSNSMLAHVNTKRHN 122 Dictyostelium discoideum AX4
Q7RIP5       127 YYCKICDCTLKDSQTYLDHINGKNHN 152 Plasmodium yoelii yoelii
XP_001609779  98 FYCKTCDCILKDSQAYMDHLNGRKHN 123 Babesia bovis T2Bo
BAE89853     167 FFCPICSLFYSGEKAMTNHCKSTRHK 192 crab-eating macaque
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