6KG7,6BPZ


Conserved Protein Domain Family
Piezo_RRas_bdg

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pfam12166: Piezo_RRas_bdg 
Piezo non-specific cation channel, R-Ras-binding domain
This is an extracellular domain at the C-terminus of Piezo, or FAM38 mechanosensitive non-specific cation channel proteins. It seems likely that this region of the Piezo proteins may be responsible for R-Ras recruitment because this region is capable of relocalising R-Ras to the ER in eukaryotes.
Statistics
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PSSM-Id: 403405
View PSSM: pfam12166
Aligned: 78 rows
Threshold Bit Score: 230.613
Threshold Setting Gi: 123472633
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6KG7_A                        2410 LVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKr-yPQPR-GQKKKKAVK-YGMGGMIIVLLICIV 2486
A0DB57                        2283 SIPFLYDLKVLMDWTCLYTSLDIYQWFILEDIQRQMFFTKISSQKVM----KRQlGLEISKISK--LIFFFFVIFILICI 2356 Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00151710A 3841 AIPFLQELKVILDWTVTKTSLTLFQWFLLEDIHYSLYVAKLDSKDVR----STKvDAPQSKLVK-IFLGLLQVIVILLLI 3915 Tetrahymena thermophila SB210...
XP_004023864                   241 AIPFMQQLKVVMDWTFTATTLDLFQWFKIEDIHFTLYCAKLDSIVQK----NKPvGQNTPWFMK-LSMGWVLLILIILLI 315  Ichthyophthirius multifiliis...
XP_001319509                  1552 AVPFLFEFIYLIKWLASTTSLDLFDFFIISQMKSKFMKQLSYLKLWPl--DNKK---------KsHIIGYLFILALFALL 1620 Trichomonas vaginalis G3...
EAY21911                      1550 KTPFLFEFIQLTKWLACTTSLNMFDFMIIGQLRSKLSKQVALLKLFPa--NSKK---------KrHTLGIFFVIGLFCLL 1618 Trichomonas vaginalis G3...
XP_001581503                  1083 KVPFLFEFIQLTKWLACTTSLNMFDFMIIGQLRSKLCKQVALLKLFPa--NSRK---------KsHVLGILFMIAMFCLL 1151 Trichomonas vaginalis G3...
XP_002499460                  3627 SVPFLFELRTLLDWVMSESSLDLLMWFRFENLYHMLWKDLLYQEARRqnkEIYSgRDKFPLVFK-MLQGFTIFTGIILLL 3705 Micromonas commoda...
4_pfamImport                     1 LAPFLFEMRALLDYLCMKTSLSWQHWILLEDTAAHVFGVKGIMKRRVeeaDILQgKRRQPMRTKiMSAGVMLLFMLIC-L 79  
XP_976967                     2843 AIPFIQELKVVMDWTFTATTLDLFQWFKIEDIHFYLFCAKVDANDNK----KKPvGMPQNWIMK-FFMGWVFLLAILLLL 2917 Tetrahymena thermophila SB210...
6KG7_A                        2487 WFPLLFMSLIKSVaGVINQPLDVSVTITLGG---Yqpiftm-------------saqqsqLKVMDNSKYNEFLksfg--- 2547
A0DB57                        2357 LGPLILFSALNPA-AQNNPIVSGSFTINLVNvdtNl-----------------------nVQFYESSQLFGLElp----- 2407 Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00151710A 3916 FGPMLLFSTLNPI-SDYNGITSGEIEVGIQFkqlGqi---------------------nyYPIFTNSHTNNLQtvqrdct 3973 Tetrahymena thermophila SB210...
XP_004023864                   316 FGPMLLFSSLNPT-TQLNSITNAKLELGLLFg-gIyg---------------------vyYPLYLNQNVKYIQtvdde-- 370  Ichthyophthirius multifiliis...
XP_001319509                  1621 FVPFIVMMSSSST-SKPNPVKVASVSIGIYGlpeIwsgtvlpdes-----nifsdtmqreILNLNDPMLDAFYs------ 1688 Trichomonas vaginalis G3...
EAY21911                      1619 FVPFVVMMSSSST-SIPNGVKVATVSLGIYGlpeLftgtvlpddt-----tlmtdsmqkhVMTMNDKTLEPFFa------ 1686 Trichomonas vaginalis G3...
XP_001581503                  1152 FAPFIVMMSSSTT-SITNNVQVASVSLGIYGlpeLftgtvlpned-----sfitnsmqkkIMAMNDQKLDPFFa------ 1219 Trichomonas vaginalis G3...
XP_002499460                  3706 LAPIFLFSSINPV-LSPNKVTSANLNVELRVrvnSslavyniyqaqaqsvemsgedidasERYLMTSPLTQKF------- 3777 Micromonas commoda...
4_pfamImport                    80 VGPLAMFSSINPS-TTANDVTLTTVKFGIEDakeTm------------------------nELYSNSDSNSPS------- 127 
XP_976967                     2918 FGPMILFSSLNPS-TQLNNITNASFEMGLQIn-gQsg---------------------nyYQFYQNGNIGNLKsvasss- 2973 Tetrahymena thermophila SB210...
6KG7_A                        2548 ---------------------pnsGAMQFLEn-yERE-----------DVTVAELEGNSNSLWTISPPSKQKMIQELt-- 2592
A0DB57                        2408 ----------------------flTDYSEIKeltKQQkitqqqidnsgGIQRFQLSDFSNQKWQVSLPLYNQLIRELnqt 2465 Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00151710A 3974 ydpqknvnnqdasqqecywdeykfRDVNIIYt-tDSQ-----------QFQKFNFYSYSENSWDLSFPSKKDIESKFedi 4041 Tetrahymena thermophila SB210...
XP_004023864                   371 -------------------dlqnfKNITQISq-sDKR-----------QFQTFVYSSSSDDNWTASKPNKDEIKMIL--- 416  Ichthyophthirius multifiliis...
XP_001319509                  1689 ---------------------------------nNKK-----------ESQYFQYPDITLTNWQISDSSANYALNKM--- 1721 Trichomonas vaginalis G3...
EAY21911                      1687 ---------------------------------nSRK-----------ESQYFTYPSITMTNWIISESSARFAMNTIk-- 1720 Trichomonas vaginalis G3...
XP_001581503                  1220 ---------------------------------nSKR-----------ESQYFNYPGITMTNWIISESSARFAMYTIk-- 1253 Trichomonas vaginalis G3...
XP_002499460                  3778 ------------------------------------------------DAECLLFPRHSSVSWVLPAGPRGALATNLvth 3809 Micromonas commoda...
4_pfamImport                   128 ---------------------------CEVDlntDSA-----------STQCIEFGVFSNDAWGLSPPRMDLLVAQL--- 166 
XP_976967                     2974 ------------------tnmdiyQNITAISq-aSPS-----------QFQQFSLYSSSDVNWQLSVPSITEIQQTLenq 3023 Tetrahymena thermophila SB210...
6KG7_A                        2593 --------------DPNSCFSVVFSWSIQRNMT-------LGAKA-EIAtdklsfp--------lavatrnSIAKMIAGN 2642
A0DB57                        2466 -----------itlDEKYHFLFNVTFTFRRRFQfilpsmyKFSYPyNPLingengtv------glgldqlkYIRNAAMAC 2528 Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00151710A 4042 l----------nnqNTSQTAQLVIKLVLNRKVS-------QYNTApYISyypnpqiqns---sylnkqiiqGFYDTLTDC 4101 Tetrahymena thermophila SB210...
XP_004023864                   417 ----------------NQTINQQIKNQVN-----------DLNSQpSTFyypfntksldsmgtsmsleqinQLYQIINCN 469  Ichthyophthirius multifiliis...
XP_001319509                  1722 -----------------TKFIPYVNFKFTTTSP-------TTKLTtDQItitktgnn-------ldeeqikTLKEIINCT 1770 Trichomonas vaginalis G3...
EAY21911                      1721 -------------nTSNPIFIPYVTFKFTVQTP-------TTKKNvDQItitkngkq-------lkpevleTLYKALECT 1773 Trichomonas vaginalis G3...
XP_001581503                  1254 -------------nTTNPIFIPYVTFKFTVQTP-------TTKKNiDQItitkngkq-------lsekdleTLYKALECT 1306 Trichomonas vaginalis G3...
XP_002499460                  3810 akwlnttrqltstsTSESQAELVFTTAFTRYGP-------PTAKTvMmevispl-----------tssqalEMGTMINDI 3871 Micromonas commoda...
4_pfamImport                   167 --------------QSTKTLKWTITFTFTRPGP-------TNAEViSakysarm-----------tdehriALIPMIKQT 214 
XP_976967                     3024 -----------iqgRTNIQIQFSVRYNIQRNVT-------SLSSQdNTFlypintqniydkstsltqeqvaQLLVVMDDC 3085 Tetrahymena thermophila SB210...
6KG7_A                        2643 DTEs----sNtPVTIEKIYPYYVKAP-SDSNSKPIKQLL-----SENNFMNITIILFRDNVTKsn----seWWVLN---- 2704
A0DB57                        2529 NT-------S-GVMLPNFYIEALRIYqSSATNYNTTPIYg---kDIPTAQDVFLNINCSYGNTnplq-gvsNWEFQyagn 2596 Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00151710A 4102 QK-------P-GVILPNFYIFLLSSTiSNQSYISSPINHednnnSAYFAKDSYIQLKCQDIQNpqt---qkYWEISid-- 4168 Tetrahymena thermophila SB210...
XP_004023864                   470 AT-------S-PLLLNNLYLELLRLDtNGKTYKARPFYSi---dYQSYIKDAYFNLICLEHGKitq---aqYFDLQiv-- 533  Ichthyophthirius multifiliis...
XP_001319509                  1771 LNTqep-enL-SLNIENLIPLYFTIPlSDEATFINKYYF-----------NLSMQFMKSQSSGq------fYWLISvn-- 1829 Trichomonas vaginalis G3...
EAY21911                      1774 MNLatp-enL-SFYLDDLVPLFFIIPlAKDASVVSNYYF-----------NTTFTFEQSTNGNf-------YWSIStk-- 1831 Trichomonas vaginalis G3...
XP_001581503                  1307 VTStspqenL-TFYLDSLVPVFFIIPlSADATAVSGYTF-----------NVTFSFQQSYSGNy-------YWSINam-- 1365 Trichomonas vaginalis G3...
XP_002499460                  3872 SDQk-----A-EVAVERALPRLLNLPpRDQVIKLSKTAPd---pNPSDDATTILSLERLDDSLm-------IWGLRtkqi 3935 Micromonas commoda...
4_pfamImport                   215 LTDgegttlP-SVQIDDFFPAVVQLTaSRGVLKRSTQMH-----------SLAVSKHSLNGST--------WWNIEpv-- 272 
XP_976967                     3086 NS-------Q-AMELPNFYISLLRLDtNGDSFEARTFSNlspsqQIAYFKSAYLNLKCKLNPDqtydenirYWVLSld-- 3155 Tetrahymena thermophila SB210...
6KG7_A                        2705 ---------LTGSRIFNQGSQALELVVFNDKVSPps-lG-FLAGY--GIMGLYASVVLVIGKFVREFFSGISHSIMFEEL 2771
A0DB57                        2597 -----sslfL--NSSNLTLPDGLLYFVICDNYSV------LTYGL--SVITIYTTVILLIAKFIRSTFSSQVFMLEFTQM 2661 Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00151710A 4169 ----------------qAGTSGLSYFVVTDKYSQ------ATFGF--SIITLYTSVILVIGKFIRDAFGGELEKIIIKCM 4224 Tetrahymena thermophila SB210...
XP_004023864                   534 ---------------gGEQGEGLNFYVLCDKYSS------FFMGF--SIITIYTSVILVIGQFIKTIFSGDIQIIVFSDL 590  Ichthyophthirius multifiliis...
XP_001319509                  1830 ---------kTEDMPDFVEEGALSSAVYCKPSYNav-iGsLLTSTg-GFYGLYVFIIFTCGTFVRSFITSFFQDLWIDRM 1898 Trichomonas vaginalis G3...
EAY21911                      1832 ---------rTAKQPVDVQEGPIGSVVFSKPTYDav-iStLMSKTggGFYGLYVFFTLSCGKMVRSFINSFFTDLWIDKM 1901 Trichomonas vaginalis G3...
XP_001581503                  1366 ---------rNENLPDDIKEGPISSIVFSKPTYDet-iGsILSKTggGFYGMLLFVIMTCGKFIRSFINSFFSDLWIDKM 1435 Trichomonas vaginalis G3...
XP_002499460                  3936 tlagvkkgfCGMVDYTEEGSQGVLYATMSDRFLSgvveQlGLDSY--SMLALYAFIFVAIGGVVRRFFQFKIEDVMIYEI 4013 Micromonas commoda...
4_pfamImport                   273 --------vSSSGSNYCSATYPFCIVAVSDRIVQgl-tTlGISSY--GLTAVYVFVVVTVGSAVKVFFRGKLFRIQYDEL 341 
XP_976967                     3156 ----------------qNGQNGLIFYVLCDKYSS------VLQGL--SIITIYTSVILVIGKLIKSVFSGDIQLLMFTDQ 3211 Tetrahymena thermophila SB210...
6KG7_A                        2772 PNVDRILKLCTDIFLVRET---GELELEEDLYAKLIFLYRSPETMIKWTRE 2819
A0DB57                        2662 VQPDDLLSICQAVSVARQL---QNYRKENLLYFELIDILRSPELVKAMTGA 2709 Paramecium tetraurelia
WGS:AAGF:cds.TTHERM_00151710A 4225 PNPDELLRICEAISNARNE---KDLLKERILYFELMDLIRSPEVLKKLTGS 4272 Tetrahymena thermophila S...
XP_004023864                   591 PNSDKLLKICDAIAVARAE---RDLIKENLLYYELIDLLRSPEVIKMITGS 638  Ichthyophthirius multifiliis
XP_001319509                  1899 GNPEIFLNVILAIEAHRNT---GDLPMEYATATMILNTARSLHNMAKIGKT 1946 Trichomonas vaginalis G3
EAY21911                      1902 GKPEIFLNVILAIEAHRKA---GDLKSEYATAMMLLNTIRSVHNLVKIGGT 1949 Trichomonas vaginalis G3
XP_001581503                  1436 GKPQIFLNVILAIEAHRKE---GDLTSEYATAMMLLNTIRSVHNLVRIGGT 1483 Trichomonas vaginalis G3
XP_002499460                  4014 PNPDYLLRLCRGLRMLRAHrypGCRRDEIKLFHTLIQMLRSPDILIKVTRN 4064 Micromonas commoda
4_pfamImport                   342 PDPGDVLELIEGIYIARHEqyvGHLKDEVRLFEMLVRVLRSPETLIKVTG- 391 
XP_976967                     3212 PHSDKLIKICDAIAYSRTE---RDLIKENLLYWELIDLMRSPEVVKMLTGS 3259 Tetrahymena thermophila S...
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