5FUR


Conserved Protein Domain Family
DUF3591

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pfam12157: DUF3591 
Protein of unknown function (DUF3591)
This domain is found in eukaryotes and is typically between 445 to 462 amino acids in length. Most members are annotated as being transcription initiation factor TFIID subunit 1, and this region is the conserved central portion of these proteins.
Statistics
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PSSM-Id: 403397
View PSSM: pfam12157
Aligned: 88 rows
Threshold Bit Score: 414.629
Threshold Setting Gi: 123492936
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5FUR_G        586 WNLSNDEYYYPK----Q---QGLRGTf-GGNIIQHSIPAVELRQpfFPTHMGPIKLRQFHRP------------------ 639 
XP_003290603  608 FNLSNDKFYKPVkk-----sNAVQQNa-GKATIQHSLPGIKLSL--VKTHLTKEDLIYAHRP------------------ 661  Dictyostelium...
EFA78451      722 FNLSNDKFYKTLg------kGRVRQQs-GKMSIQHSLPAIKLSL--VKTHLSIEDLTHMHRP------------------ 774  Heterostelium...
EGG16797      657 FNLSNDKYY--RqgvnR---SRVRQQs-GKALVQHSLPAIKLCL--TKTHFTLDDLESYHRP------------------ 710  Cavenderia fa...
PWA89578      548 FNISNDKFYSNRkssqQqlkSHSKKRagHGVKVLHSIPALKLQT--MKVKLSNKDLAYFHRPkalwhphenvvalkeqgt 625  sweet wormwood
XP_001326171  295 LKFHCDEYYMSLtenfL-------SSr-PNLDIQHSDVATNL----YLIEPNPHDIETQHHP------------------ 344  Trichomonas v...
XP_001583472  336 ISFHSEKYYTRLkvakE---NRMHQAv------QHSDPALNL----VLIEPNLRDLENFHHP------------------ 384  Trichomonas v...
EFP03078      505 FNLSNDDYYVPKa--tS---KTLSN---NSLLIQHSTPATNIATqfFPTHPSAFRLRYWHRT------------------ 558  Caenorhabditi...
Q54DH8        839 FNLSNDKFYRPVrkppP---RPPNGS--TKVVIQHSLPGIKLSL--VKTHLTKEDLIYAHRP------------------ 893  Dictyostelium...
XP_007491796  103 WNLSNDEFYFPQ----Q---HGLQVSl-KIPIIQHSTPALELHFrlFPTHMGVEQLRLFHRP------------------ 156  gray short-ta...
5FUR_G        640 --------------------------------------PL-KkysfgaLSq-----PGPHSV-----QP----------- 659 
XP_003290603  662 --------------------------------------RL-L------FP------SNVLFKia--lYN----------- 677  Dictyostelium...
EFA78451      775 --------------------------------------VI-A------FQ------AGHQFRia--lYN----------- 790  Heterostelium...
EGG16797      711 --------------------------------------RI-Q------FP------PQHTFRia--lFH----------- 726  Cavenderia fa...
PWA89578      626 llergsmkvvlkslggkgsklhvnaeetvlsvkgkatkKL-D------FK------PSEPVKi---iYSgkeledeksla 689  sweet wormwood
XP_001326171  345 --------------------------------------RL-N------TLq----iLGLPLKi---tYD----------- 361  Trichomonas v...
XP_001583472  385 --------------------------------------HVnT------LPil---gITYTVT-----WK----------- 401  Trichomonas v...
EFP03078      559 --------------------------------------PF-T------RRivkhwqPNRFQQiqvrkHN----------- 582  Caenorhabditi...
Q54DH8        894 --------------------------------------RI-L------FP------SNVPFRii--iYNkegs------l 914  Dictyostelium...
XP_007491796  157 --------------------------------------PL-R------WLg-----RGPHPV-----HN----------- 170  gray short-ta...
5FUR_G        660 --LLKH------IKKKaKM-------ReqerqasGGG----------------EMFF----MRTPQDLTGKD-GDLILAE 703 
XP_003290603  678 --KEGA------ITSNeQLnsstsnlN-------GSVnglrtgggfdsfsgssSSSLsskkSLHKSDLSGRD-GRVVLVE 741  Dictyostelium...
EFA78451      791 --KDRP------DDKP-KQ-------R-------GSN----------------RADP----MKHKLDLSARE-GRVIFVE 826  Heterostelium...
EGG16797      727 --KEAH------RDDRgRT-------R-------VAD----------------PS------MKHKIDLSARE-GRVVFVE 761  Cavenderia fa...
PWA89578      690 eqDVRPnsllhlVRTRiHLlpkaqklP-------GEN----------------KSLRppgaFKKKSDLSARD-GHVFLME 745  sweet wormwood
XP_001326171  362 --PKTH------PSYSnEF-------D-------TVQ----------------ISPY----LRDFESLSGRNgRKLILLE 399  Trichomonas v...
XP_001583472  402 --PDEI------PDDD----------P-------DAQ----------------ISPF----LKDLDDLSGRR-GGIIVVE 435  Trichomonas v...
EFP03078      583 --PARH------QQRVqAMregmrqsQ-------GGG----------------EVFY----MREINDLSGKD-ENLVMIE 626  Caenorhabditi...
Q54DH8        915 sgDLSS------SSNNlLLnsstnsiM-------GGHnmrgsinggmmsssssSSSSsskkSLHKSDLSARD-GRLVLIE 980  Dictyostelium...
XP_007491796  171 --LTVH------IRKKaQKreqelqaS-------GGG----------------HMFF----MKTIQDLSGKD-GDIVLFE 214  gray short-ta...
5FUR_G        704 YSEENGPLMMQVGMATKIKNYYKRKPGKDPGAP-----DCKY--GETVYC---HTSPFLGSLHPGQLLQAFENNLFRAPI 773 
XP_003290603  742 YTEQNPPLLSNVGMGMKIRNYYRKKSNHDSAK------DVEFedGELVVIdsnDDSPFLGDIYPGQAVQAVVNNLYKSPV 815  Dictyostelium...
EFA78451      827 YMEQNPPLLSNVGMATRVRNYYRRKNSDDDQFL-----TFDD--GETVMLdhnDESPFLGEINPGVPIQSMVNNLYKAPI 899  Heterostelium...
EGG16797      762 YLEQHPALLNNVGMGARIRNFYRRKNASDA--P-----FLSFedGENVLLdtnDETPFLGDITPGRTIQALVSNLYKAPI 834  Cavenderia fa...
PWA89578      746 YCEERPLLLGNPGMGARLCTYYQKVSPGDQAGThlrsgPNNL--GNVLTLdpaDKSPFLGDIKPGSTQSCLETNMYRAPV 823  sweet wormwood
XP_001326171  400 HTSENPAFILNVGMASRLITYYHQATAEDIPRS-----LIE---SDTHLIkpnQASPFLASIPKSTPIHTISCNMFDVPV 471  Trichomonas v...
XP_001583472  436 HTVEYPQFITNVGMASTLVTFWHKAHANDNPR------TFD---QHIQILdpdHASPFIGEIPKNEPVQCLSCNMFNVPV 506  Trichomonas v...
EFP03078      627 YSEEHPVILSQPGMASKMKNYFKRRQAND-TEP-----TFDY--GEMAFS---HQIPFLGQLQPGQSLQSIENNLYRAPI 695  Caenorhabditi...
Q54DH8        981 YTEQHPPLVSNVGMGLRIRNYYKKKNTHDTGPK-----DLNFedGELVMLdnnEESPFLGDINPGQTIQSVVNNLFKVPI 1055 Dictyostelium...
XP_007491796  215 WSEENPPLLSQVGMASQIQNYYKRKIGKDSGPP-----AYKY--GNLVFC---STSPFLGQLQAGQFLQALENNLFRAPI 284  gray short-ta...
5FUR_G        774 YLHKMPETDFLIIRTRQG---YYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKD---RprRIR 847 
XP_003290603  816 YKHNSSNTDFLLVRSRDGk-rWYIRDLGPVYSAGQMLPEIEVPAPNSRSANMFLKSRLQAYIYRLFLKKSNs--Qr-RLK 891  Dictyostelium...
EFA78451      900 AKHNPNPTDFLLIRSRDGk-kWYIREMGTMYTAGQMMPEIEVPAPNSRSANMFVKSRLQAYIYRLFLKKSNi--Qr-RLK 975  Heterostelium...
EGG16797      835 FRHNPSPTDFLLIRSRDGk-kWYIREMGTLYTAGQQMPEVEVPAPNSRSANMFLKNRLQAFIHRLFRKKKNv--Qr-RIR 910  Cavenderia fa...
PWA89578      824 YPHKVSSTDYLLIRSAKGk--LSLRRIDRIYAVGQQEPHMEVMSPASKVLQTYNMNRLLVFMYREFRACQKrglAp-AIR 900  sweet wormwood
XP_001326171  472 AKHDVEPTDFLLIRDMednrkFYIRHIDATYCASLLEARVKVMRPNKKVTQTFITNFITAILVNIFRGNKQykgRs-RIQ 550  Trichomonas v...
XP_001583472  507 AKHPVESTDFLLVRSlde-pvFYLRNIDACYCAGLLEARTKVMRPGTKDAQKFNLNFIKAILINIFRGTKQypgRh-HIQ 584  Trichomonas v...
EFP03078      696 YLHKRQSTDFLLIRSQNQ---WFIRPIPAIFIAGQQCPLYEVPSPNSKRATVFVRDFLFAFIYRLFWASEHs--Pr-RLK 769  Caenorhabditi...
Q54DH8       1056 HKHNSANTDFLLVKSRDGk-rWYIRDVGPIYAAGQILPEVEVPAPNSRNANMFLKSRLQAYIYRQFLKKSNp--Qr-RLK 1131 Dictyostelium...
XP_007491796  285 YAHEMAGTDFLVVVTNTG---CFLREVKDIFAIGQQCPLDEVPAPKSKMAKNYSHTFLQVFIYRQFQNSPFr--Pr-RIR 358  gray short-ta...
5FUR_G        848 MEDIKK-AFPSHSESSIRKRLKLCADFKRtgmDSNWWVL--KSDFRLPTEEEIRAM-VSPEQCCAYYSMIAAEQRLKDAG 923 
XP_003290603  892 ITDICS-SFPSQSETSIRKRLKDCADFQRggdDSGWWTV--KDNFPLPTEEELQKL-VTPEVVCAYESMLIGLQRLQDNG 967  Dictyostelium...
EFA78451      976 ISDVCT-AFPGQSETSIRKRLKDCSDFQRggdDSGWWTV--KDNFPLPTEEELQKL-VTPEVVCAYEAMLSGLQRIQDSG 1051 Heterostelium...
EGG16797      911 IQDVCN-AFPSQSEASIRKRLKDCADLQRggeDGGWWIL--KDSYRLPPEEEIQKS-VTPELVCTFESMLVGLYHLQANG 986  Cavenderia fa...
PWA89578      901 ANELSA-LFANVAEIPLRKRLKVFCDFQRg-----sWVM--KRNFRIPLEEELRRL-VTPEHVCAFESMLAGMYRLKRLG 971  sweet wormwood
XP_001326171  551 VSSVLKeFFPDMNELKLREVLKKFAKNYRe-qGSGYWEPveKDLDAFFGT----IQ-ITPEDVCSYQSMQAGFKKLRRSG 624  Trichomonas v...
XP_001583472  585 VQNVIKeFFPDVNEPKLRNILKDFADFYRe-qGNGFWRI--KE--KINLDAEFQKIdITPEDVCSYQSMLVGHYHLKKSG 659  Trichomonas v...
EFP03078      770 MEDVRN-AFPHYAESNIRKRLKMCSTYTRngaDT-FWSL--KPEFRLPSKEEVLSM-VTPEMCCAQYSMMAAEQRLKDAG 844  Caenorhabditi...
Q54DH8       1132 ITDICS-AFPSQSETSIRKRLKDCADFQRggdDSGWWTV--KDNFTLPTEEEFQKL-VTPEAVVSFESMLIGLQRLQDNG 1207 Dictyostelium...
XP_007491796  359 MEVIRK-AFPTLSETSIRRRLVMCSDFHRsgiYFNWWVL--KARFRLPSEEELRVM-MTPEKCCALYSMLAAQQRLKDAG 434  gray short-ta...
5FUR_G        924 YGEks---------ffAPEEENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGK----CLLEVTGVaDPTGCGEGFSYVKIP 990 
XP_003290603  968 IIHftaqgtiptilggLDEDDPIKKSYKPVEDELSITPWNLTGSFQAAMQGK----GRMQIISE-DPTAREDEFCYLKMP 1042 Dictyostelium...
EFA78451     1052 IIHftnagtiptmlsnLDENEPLRKKCKPVEDELNQTPWNLSASFVSAMQGK----GKLQLIGD-DP--RGEMFSFLKMP 1124 Heterostelium...
EGG16797      987 IIHftspgt-ipmftqRESADPNRDRYKLVEDELNRTPWNLTSSFTQAMQGK----GKMQLVSD-DPDNNET-FSYLKMP 1059 Cavenderia fa...
PWA89578      972 ISMthpagl-saamnqLPDEAIALAAASHIERELQITPWNLSSNFVACTNQDrgnlERLEITGVgDPSGRGLGFSYVRTA 1050 sweet wormwood
XP_001326171  625 VNMlirskr-vyqqiqNLKGELTKKVAEKIELELMKTPWARTENFTKAFDGQ-----LMEM------SRADTGEQIVRTK 692  Trichomonas v...
XP_001583472  660 VNIlirskr-vyqqiqKLEGELTKKVAARIEIELMKTPWARTENFVKAFEGQ----A-MQIQRTeD------GQQIMRSK 727  Trichomonas v...
EFP03078      845 YGEky---------ffTPENDEGSDDEVTIEDEIKCAPWNTTRAFMASQREK----CLLDQTGIaDPTGCGQGFSYVRVS 911  Caenorhabditi...
Q54DH8       1208 IIHftapgtiptilgnLDDEDPIKKSIKPVEDELSITPWNLTGSFLSAMQGK----GRLQIISD-DPTGREDEYSYLKMP 1282 Dictyostelium...
XP_007491796  435 YGGi-----------sLLDTEGTNDDSTYLDDEVQAAPWNTTRTFLAATKGQ----CLLEVTGAaDPTGCGEGISYVKLK 499  gray short-ta...
5FUR_G        991 -NKPtqQKDD-K-------EpqpvKKTVTGTDadlRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDV 1049
XP_003290603 1043 -QKV--VNQK-QkaiklalQ----KNQVTGTDadlRKLSLSASKTVLLELGVSEEKINSLTRWQRIDL 1102 Dictyostelium purpureum
EFA78451     1125 -QKV--VNQK-QkaikqalQ----KNQVTGTDadlRKLSLKESKIVLLQLGVTEEVINNLTRWQRIAL 1184 Heterostelium album PN500
EGG16797     1060 -QKV--VNQK-QkdlkkqlQ----KNQVTGTDadlRKLSLKESETVLLKLGVSEEVINSLTRWKRIAL 1119 Cavenderia fasciculata
PWA89578     1051 -PKApvSNAVaKkkvpinrG----GLTVTGTDadlRRLSMKAAREVLMKFNVPEDQIAKLTRWHRIAM 1113 sweet wormwood
XP_001326171  693 -GRRgkSEAG-Eqk----eP----KKQRYGTDadlRVLHIPQLNEKLRSYGIPEEQIARLLRWDKVKL 750  Trichomonas vaginalis G3
XP_001583472  728 -SRRehDNSAgApq---paP----KKPLAGTKadlRALTLRELRDKLVSLGVPTGEIERLSRWNQVAL 787  Trichomonas vaginalis G3
EFP03078      912 -QKPh-KDEN-Atp----vP----KKLVTGTNadlRKLPLKEAKQICRGYGVKEEEISALTRWEIIDV 968  Caenorhabditis remanei
Q54DH8       1283 -QKV--VNQK-QkaiklalQ----KNQVTGTDadlRKLSLSASKTVLLELGVDEETINKLARWQRIDL 1342 Dictyostelium discoideum
XP_007491796  500 qENKthTDVG----------------RVMGTDadlRRLTLREAQKFLRTFGVSEEEIKKLSRWEVIAA 551  gray short-tailed opossum
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