6FC0


Conserved Protein Domain Family
eIF_4G1

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pfam12152: eIF_4G1 
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Eukaryotic translation initiation factor 4G1
This domain is found in eukaryotes, and is about 80 amino acids in length. It is found in association with pfam02854. This domain is part of the protein eIF_4G. It binds to eIF_4E by wrapping around its N terminal to form the eIF_4F complex. This complex binds various eIF_4E-BPs (binding proteins) to regulate initiation of translation.
Statistics
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PSSM-Id: 403394
View PSSM: pfam12152
Aligned: 50 rows
Threshold Bit Score: 55.6764
Threshold Setting Gi: 74604651
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6FC0_B          5 QPSAALQSLRSARFLPGIVQ-DIYPPGIKSPNPALN-EAVQkkgriFKYDVQFLLQFQNVFTEKPS 68   Chaetomium thermophilum var...
CCX31323      679 LPSAALTALRSARPIETLKG-LEYPEGIQSPNPALNpTAAPa---kFRYDKDFLMQFQTVFTDKPS 740  Pyronema omphalodes CBS 100304
XP_016759574  875 EPTPGMQALKSSRFLEIKEE-AKYPDGFKSPNPALN-PAGGrk--gHAYNKEFLLQFQNVFKEKPS 936  Sphaerulina musiva SO2202
XP_003834529  750 QPTAGMQALKSARFLQVKAElVKYPEGIQSPNPALN-LSTKsk--gRQYDKDFLLQFQEVFKEKPS 812  Leptosphaeria maculans JN3
XP_003030647  151 EFAPFNAALANARAIGDITS-VQYPEGIICPAAEMNiHTKNg---rFIYDRGFLLQFSDVCKERPG 212  Schizophyllum commune H4-8
XP_007417007  879 TMSPLPSALSSARKIEDLGQ-VSYPENIKSPHPDLNaEAAPg---kFRYDRAFLLQFMEVCKGKPT 940  Melampsora larici-populina ...
Q5KP78        679 TPSASASALSSARPINDLSS-ITYPATLKSPDPRLNvDAEPg---kFRYDREFLMQFMAVCREKPD 740  Cryptococcus neoformans
GAC74445     1370 SSSGASASLVAAKFIDSFSK-VNYPTNINSPKPELNqSAEPg---kFRYDRDFLMQFMGVYTEKPI 1431 Moesziomyces antarcticus T-34
XP_006958195  505 STQKPSQALGAARRIDDLTK-ISYPGDIKSPKAELNkQARPg---kFRYDRDFLMQFMSVFTDKPA 566  Wallemia mellicola CBS 633.66
EDP42485      534 SSSEPSRAIEHARAIEDLSS-VPYPPDVHPPQAELNkEAAPg---kYRYDRDFLLQFMSVYSEKPf 595  Malassezia globosa CBS 7966
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