6B9M,4TVR


Conserved Protein Domain Family
TTD

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pfam12148: TTD 
Tandem tudor domain within UHRF1
TTD, tandem tudor domain within UHRF1 preferentially binds H3 histone tails trimethylated at Lys-9. It specifically recognizes H3 tail peptides with the heterochromatin-associated modification state of trimethylated lysine 9 and unmodified lysine 4 (H3K4me0/K9me3). This domain is found in eukaryotes and is found in association with pfam00097, pfam02182, pfam00628, pfam00240.
Statistics
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PSSM-Id: 403391
View PSSM: pfam12148
Aligned: 36 rows
Threshold Bit Score: 188.591
Threshold Setting Gi: 1008428617
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6B9M_A         8 GFYKINEFVDARDLNMGAWFEAQIVKVTKTPAED---------------------------------------------- 41 
OWR50446     167 PPSNISEQSNTQKIGIAKYFTKQTNGKRLSKDFKvktv------------------------------------------ 204 Danaus plexippu...
XP_001952821 117 KYFKVGDYVDVKDYTYGSWFISKLIKIKKDSCAV---------------------------------------------- 150 pea aphid
XP_001944935  69 KYFKLGDYVDIRDFEYGVWYMGKIVKIKKDDSSQ---------------------------------------------- 102 pea aphid
7_pfamImport   1 -AHNIGDIVDARDICYGAWFEGKITGIFKNPDTVedte------------------------------------------ 37 
XP_015840551 104 RYYEIGDKIDVIDSDHGAWFEAKILGIFKPKETEna-------------------------------------------- 139 red flour beetle
ESO04458     135 NIYKVGDVLDVRDGTLGAWFEGGIVKVVSRACKNnnknnin-----------------------------------vvnn 179 Helobdella robusta
XP_011454836 143 STYKLGDIIDARDTSVGAWFEAKIVKISKDDKNErk-------------------------------------------- 178 Pacific oyster
EDO40465     128 SIYKKGEFIDAKDPSMGAWFEAEIVDISLKDESDp--------------------------------------------- 162 starlet sea ane...
XP_009023456 134 NLYKVGDVLDIRDVTLGAWFEGDLVKVVPRTRRInnnnsnnndisnsndsskdiglddkeskvsgmkedkmkkkdetnhg 213 Helobdella robusta
6B9M_A        42 ---GGP----------EE-IVYHVKYEDYPENGVVQL-RGKDVRPRARTVYQWRQLEPGMIVMVNYNPDDPKERGYWYDA 106
OWR50446     205 -------------kvtAEnVLYKVQLDDDEEDSELFC-KLKEIRPRARHEIDVKDLMPGQKVMINHNTDEPLEKGYWYDF 270 Danaus plexippu...
XP_001952821 151 -----NkpndpkspveNDgLVYVAEILRCPEEPPIEV-QLQEIRPHAFDILPFEKLKTNDRVLMNYNVDYPQERGYWYDV 224 pea aphid
XP_001944935 103 -----IeptsssdnleDDgLIYFVEDIGCPTNPPTKA-KLKEIRPYSTDILPFDQLKINDKVLMNYNQDYPKERGYWFDV 176 pea aphid
7_pfamImport  38 -------------tenEDgILYKVLLNRYPFTNPLLL-SLKDVRPRARNKISALTVKEGQIVMINYNIEQPTQRGFWYDL 103
XP_015840551 140 ---------------dEKdLTFRIKMDRNGNTAAFDV-TFSEIRPRAYYTYHKSELTPGVIVLANYNIEEPTSRGYWYDF 203 red flour beetle
ESO04458     180 nikNIDlnteeskindDD-------------SRDLTMvASRDLRPRSYRKISLTNLKINEKVMVNYNYDEPASRGYWYDA 246 Helobdella robusta
XP_011454836 179 -tdGEKmetdddgqsdHDgYIYSVVFDGYDDSEPEKL-ECKDIRPRARKVLSLGDITEGQKVMANYNVDDPDLRGFWYDC 256 Pacific oyster
EDO40465     163 ----------------ES-VLYHVKYDGYEEDEINKL-PGRDIRPRARKRLQWDQLSVGQVVMANYCPDEPKERGFWYDV 224 starlet sea ane...
XP_009023456 214 skrDDDddddkndgddDDgYEYHVRYIGDDDSSDLTIvTSKDLRPRSYRKISLIDLKVSEKVMVNYNYDEPADRGYWYDA 293 Helobdella robusta
6B9M_A       107 EIQRK--RE-TRTQ----------REVFGKILLGDAGDS----LNDCRIMFVTEIYKIEEPG 151
OWR50446     271 KVDEI--KK-LRTS----------YEIVGTLYLGPDSVP----QNDTKVKIHDKIFTIEEPv 315 Danaus plexippus plexippus
XP_001952821 225 LVKEI--KT-NRRG----------RDVIGDVSVGLDNAV----LKNCHLMFLDDIYIVkpyq 269 pea aphid
XP_001944935 177 VVKQI--IV-NRRI----------REVVGNVTIGSNKAV----LDNCNLKFVDDIFKIKpyk 221 pea aphid
7_pfamImport 104 LVTSVvkKNlEKTA-----------KIKGNLLVGYGDNV----LNNCNVKFTDDIMEIER-- 148
XP_015840551 204 EIKEI-------TK----------KGIKGALLVGTELAR----LENCTTQFVDELLRIENPK 244 red flour beetle
ESO04458     247 VITKI--KD-TKSS----------KDVYATVYIGKDLVP----MENCKLPFVNEIFMIESPG 291 Helobdella robusta
XP_011454836 257 IIKGK--RN-TRTI----------KELTATVFIGPDLMP----LDDCKLLFVNEIFDIEKPG 301 Pacific oyster
EDO40465     225 QITKK--HSkQITQggaesrsgsgRELHAKLILSNEEDShapvAQECRLIFLDEIFKIEAPp 284 starlet sea anemone
XP_009023456 294 VITEI--KN-TKSS----------KDVYATIYIGKDLVP----MENCRLPFMNEIFVIESPG 338 Helobdella robusta
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