Conserved Protein Domain Family
Med12-LCEWAV

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pfam12145: Med12-LCEWAV 
Eukaryotic Mediator 12 subunit domain
This domain is found in eukaryotes, and is typically between 325 and 354 amino acids in length. The function of this particular region of the Mediator subunit Med12 is not known, but there is a conserved sequence motif: LCEWAV, from which the name derives.
Statistics
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PSSM-Id: 403388
View PSSM: pfam12145
Aligned: 18 rows
Threshold Bit Score: 538.519
Threshold Setting Gi: 156224356
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001944097  286 EFCQSELLSRKLVYFCSRKLNTI------------CNSVIDlnppqsptskgaSNNSVPSNTSSATNA------------ 341  pea aphid
EDO45182        4 QFVLSQTLAKSLAQVCTKKLSTLylaaeqmqseqpPNQATKpqtnns-fptalSTNGSNDSSFTPVTSss--------st 74   starlet sea a...
3_pfamImport    1 ---MNQLLARRMSFAAARHLNWLfl--------------------------egSNSRSQSPALQSGSNtpgtpqlitrpt 51  
XP_014344111  283 EFVQSAYLSRRLAYFCTRRLSLM------------LSESPnlisah-sphviiGSNNLPLAAPSPTTTgavv-----spm 344  coelacanth
1_pfamImport    1 EFVQSAYLSRRLAYFCARRLALL------------LSDSSglltah-sphmmiGPNNASIGAPSPGPPgpgv-----spv 62  
Q8BQM9        283 EFVQSAYLSRRLAYFCARRLSLL------------LSDSPnllaah-sphmiiGTNNTSIGTPSPGTPgpgm-----spv 344  house mouse
Q2QCI8        285 EFVQSAYLSRRLAYFCTRRLNLL------------LSDGSIgpgpgghqahgiSAQQGNALPPTPTSQpagg-----nqp 347  zebrafish
XP_008119976  286 EFVQSAYLSRRLAYFCTRRLAML------------LDstggh------qahhlSAQAAPPLPSTPTPQpaag-----npp 342  green anole
Q7YQK8        133 EFVQSAYLSRRLAYFCTRRLALQ------------LDgvssh------sshviSAQSTSTLPTTPAPQppts-----stp 189  chimpanzee
Q16ZB3        333 DFVQSERFSRRLAYAVCKKLAHL------------INKMSTesd-------ikTEDGSREnp-----------------f 376  yellow fever ...
XP_001944097  342 ASTLNDMMSCPHH-RDILLPLSCIIQVILLECPTSLIWN-HSGGGKLPSVLN-----------GSPLDYLPCSPVVLPMP 408  pea aphid
EDO45182       75 STVLSQYKNCSQH-NSLVLALGAIIQAVTICCPGALVWNsTVCSSGQSSSSNnsgdqtkpqvlGSPLDRLPMAPSALPMP 153  starlet sea a...
3_pfamImport   52 PPQLKQ--QCPDYlLSIAHTLGCAIQCTVISCPGALVWY-QPVDAKSC---------------GSPLDLLPCASSDLPLP 113 
XP_014344111  345 QSAFSDFLSCAQH-RPLIYGLSCMLQTITLCCPSALVWNyYTSESKSSNP-------------GSPLDFLQVAPSSLPIP 410  coelacanth
1_pfamImport   63 QLAFSDFLSCAQH-GPLIYGLSCMLQTVTLCCPSALVWNySTNDSKSVNP-------------GSPLDLLQVAPSSLPMP 128 
Q8BQM9        345 QLAFSDFLSCAQH-GPLVYGLSCMLQTVTLCCPSALVWNySTNENKISNP-------------GSPLDLLQVAPSSLPMP 410  house mouse
Q2QCI8        348 QTPFTDFYICPQH-RPVVFGLSCMLQSIVLCCPSALVWHySLTDSRNKT--------------GSPLDLLPIAPSNLPMP 412  zebrafish
XP_008119976  343 PSPFSDLLLCPQH-RPVVFGLSCILQSIVLCCPSALVWHySLTDSRIKT--------------GSPLDHLPIAPSNLPMP 407  green anole
Q7YQK8        190 STPFSDLLMCPQH-RPLVFGLSCILQTILLCCPSALVWHySLTDSRIKT--------------GSPLDHLPIAPSNLPMP 254  chimpanzee
Q16ZB3        377 DSIFSEYMSCCHH-RDLILQLSSIVQVITLECPTALVWC-GIGETRSSSVLA-----------GSPLDHLPVAPSGLPMP 443  yellow fever ...
XP_001944097  409 QRT--N--NIPLRKQLKQAEEIVKIRSQAAEGRWCLDKFHkSSIGA-----KTIKILNVLDALDRHSFERIDQN---NSL 476  pea aphid
EDO45182      154 GGGnnNpiNQEVMLSLLASEESVKTRGLAVESRWSPDKYQdKTSAVcfsviAVNRVLTTLEILDKYDFTRADNT---NCI 230  starlet sea a...
3_pfamImport  114 DVPkqD--LIKHRLLLQQQEAEIIRRSRASEMKWSTDKCQeSTAGH-----TINRVLGALEALDKQHFERRTTDswcDPL 186 
XP_014344111  411 GGNsvF--NQQVRAKIHEIEQQIKQRGRAIEVRWSFDKCQeSVAGF-----PIYKVLHILEVLDRHCFDRSDSS---NSL 480  coelacanth
1_pfamImport  129 GGNtaF--NQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQeSTAGV-----TISRVLHTLEVLDRHCFDRTDSS---NSL 198 
Q8BQM9        411 GGNtaF--NQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQeSTAGV-----TISRVLHTLEVLDRHCFDRTDSS---NSM 480  house mouse
Q2QCI8        413 GGNstF--NQQVRAKVREIEEQIKERGQAVEFRWSFDKCQeTTAGF-----TISRVLHTLEVLDNHSFEKSDFS---NSL 482  zebrafish
XP_008119976  408 GVNtgF--MQQVRAKLREIEQQIKERGQAVEVRWSFDKCQeATAGF-----TIGRVLHTLEVLDSHSFERSDFS---NSL 477  green anole
Q7YQK8        255 EGNsaF--TQQVRAKLREIEQQIKERGQAVEVRWSFDKCQeATAGF-----TIGRVLHTLEVLDSHSFERSDFS---NSL 324  chimpanzee
Q16ZB3        444 SRCekS--NEDVRKKLLQAEESIKIRSRHAESRWCIDKWQ-TAAGN-----ASLKILTVLDALDGHCFDRMDTN---NSL 512  yellow fever ...
XP_001944097  477 DTLYNKIFLPPNSKdnsnpllgnism------------------stenetlkdnrSEYNVEQDQIVVKVLCEWALSSLRR 538  pea aphid
EDO45182      231 DLLYAKIFTSASKGnrevnitcvfwylkllpphlinmlessssvsssninfslriTSWLTSTDEAIALLLCEWAISKHRV 310  starlet sea a...
3_pfamImport  187 DSLYHKIFDPGQEKdc--------------------------------------dIQLTKSSEDAVVGLLCEWAISPKRL 228 
XP_014344111  481 DTLYHKIFWPNQSKdsq----------------------------------------eiLPNGEAVVTLLCEWAVSCKRF 520  coelacanth
1_pfamImport  199 -----RRFIASSSEglrpef----------------------------------enhevAPSDEAVVTLLCEWAVSCKRS 239 
Q8BQM9        481 ETLYHKIFWANQNKdnq----------------------------------------evAPNDEAVVTLLCEWAVSCKRS 520  house mouse
Q2QCI8        483 DSLYNRIFGSGQSKdgh----------------------------------------emSPDDDAVVTLLCEWAVSCKRS 522  zebrafish
XP_008119976  478 DSLYNRIFGAGPSKdsh----------------------------------------eiSPDDDAVVALLCEWAVSHKRS 517  green anole
Q7YQK8        325 DSLCNRIFGLGPSKdgh----------------------------------------eiSSDDDAVVSLLCEWAVSCKRS 364  chimpanzee
Q16ZB3        513 DTLYQKIFPPLQQRpkhqse-----------------------------qagprfPCEQYHRDESIVKILCEWAVSWQRW 563  yellow fever ...
XP_001944097  539 GEHRGMAVARLLDKRQAEITgRESDSSvevvpgGPSEDKDSIVST----PATLPLFQPLLMNFLDHDAPVL---ENTSTS 611  pea aphid
EDO45182      311 GKHRAFVVAKLLQRRQSDLLnKKDDST------SGGEESNSSRHN----PIATPVCQKVLLEFLDNYAPVVesyQHSKGD 380  starlet sea a...
3_pfamImport  229 GVHRAAVVAKLLDLRQQAELpEPPMEN------DTS--LNTSESMppnlASATPYFQNLLFTFLDVQAPELskeNRDDFE 300 
XP_014344111  521 GKHRAVAVAKLLEKRQVEVEaERCGES------EVLDEKESISSVsl-aGSSLPVFQNILLKYLDTQGPVLt-dPNNETE 592  coelacanth
1_pfamImport  240 GKHRAMAVAKLLEKRQAEIEaERCGES------EVLDEKESISSAsl-aGSSLPVFQNVLLRFLDTQAPSLs-dPNSECE 311 
Q8BQM9        521 GKHRAMAVAKLLEKRQAEIEaERCGES------EVLDEKESISSAsl-aGSSLPVFQNVLLRFLDTQAPALs-dPNSECE 592  house mouse
Q2QCI8        523 GPHRAMVVAKLLEKRQTEIEaERCGES------EVVDEKGSVSSGslsaATL-PVFQDVLLQFLDTQAPVLt-ePGNESE 594  zebrafish
XP_008119976  518 GRHRAMVVAKLLEKRHSEIEaERCGDS------EVVDEKGSISSGslsaVNA-PVFQDVLMQFLDTQAPMLt-ePANENE 589  green anole
Q7YQK8        365 GRHRAMVVAKLLEKRQAEIEaERCGES------EAADEKGSIASGslsaPSA-PIFQDVLLQFLDTQAPMLt-dPRSENE 436  chimpanzee
Q16ZB3        564 GEHRAMAVAWLLDKRQNDVFtTYENESgn--naNSSDDKDSVISGgg-pGGGLPIFQNILMKFLDNDAPTLd-eHGTQHN 639  yellow fever ...
XP_001944097  612 RTT-FTNLVHVFTELIRNDVFSHDAYMCTLISRGDLQSTNNIGmcq-----------pgsNKPadt-------psgAGPS 672  pea aphid
EDO45182      381 PS--FAQLVLLFVELVRHDVFSHNAYLCTLISRGDLQPTPAVSi----------------PSPprqigetplplpvMSDI 442  starlet sea a...
3_pfamImport  301 EIQsFRNLVLLFSELIEHDVFSHDIYMNTLISRGEISSAWTAT-----------------RYPtip--------asTDQR 355 
XP_014344111  593 KTE-FINLVLLFCEFIRHDVFSHDAYMCTLISRGDLSSMISA------------------AGPrs----------pAGEN 643  coelacanth
1_pfamImport  312 KAE-FVNLVLLFCEFIRHDVFSHDAYMCTLISRGDL-SVTSS------------------TRPrs----------pSGEN 361 
Q8BQM9        593 KVE-FVNLVLLFCEFIRHDVFSHDAYMCTLISRGDL-SVTAS------------------TGLrs----------pAGEN 642  house mouse
Q2QCI8        595 RVE-FSNLVLLFYELIRHDVFSHNIYMCTLISRGDLASNSHL------------------PRPrs----------pSDEP 645  zebrafish
XP_008119976  590 KVE-FFNLVLLFCELVRHDVFSHNMYMCTLISRGDLAIDHG-------------------PRPps----------pFDDA 639  green anole
Q7YQK8        437 RVE-FFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPG------------------PRPps----------pFDDP 487  chimpanzee
Q16ZB3        640 KSQ-FTNLVHLFSELIRHDVFSHDAYMCTLISRGDLLTGSGMsvldvqsncpglvtgpisNKP--------------NTS 704  yellow fever ...
XP_001944097  673 QAQVHMEDDN---LFDLKPNvpehhnrHMDYD---DSKIDDDLDKL------------------LQHIKEEQQNSMDAPD 728  pea aphid
EDO45182      443 EECVQEGDAHgvpGMDVPMSth---edVLRKDlssELELDREL-----------------------TLHQEQLERL---- 492  starlet sea a...
3_pfamImport  356 YDSNGYFGESvfsPMDCRVD-------RHFLD---AVRIDSTTGK--------------------------------SPP 393 
XP_014344111  644 PSEHYRKDHElkqEIFSPMPgep--ltYENVNc-lDRRIAVIEEMA---------------------WRTEKQKELV--- 696  coelacanth
1_pfamImport  362 ADEHYPKDHDmkmE----APgls---ysKDFNmsvRLLLFVSKEKFsvskfkitlrcrgrgegdPQ--RTDIRKEVKpar 432 
Q8BQM9        643 SDEHYSKDHDmkmEIFSPMPge----scENINpslSRRLSVNGEKL---------------------LKREKPRELI--- 694  house mouse
Q2QCI8        646 SDESERKDQDagsSVKMEDTgm---seSMEIDh-nSSANFDEMfsppmhc-------eskgspsPEKQAQEQESKSTakd 714  zebrafish
XP_008119976  640 AEDHDRKEGEgnsGIKLEDTgls--ecQMDIDh-nSSAIFDDMEKTdfsmfsppmhceakaspsPEKLDPEKESKLLllk 716  green anole
Q7YQK8        488 ADDAEHKEAEgssSSKLEDPgl---seSMDIDp-sSSVLFEDMEKPdfslfsptmpcegkgspsPE--KPDVEKEVKppp 561  chimpanzee
Q16ZB3        705 SPNVNQSMDEdvmQNDFKAK-------LEDLD---DSNVDDDLDKL------------------LQHIKEDQQNSMDAPD 756  yellow fever ...
XP_001944097  729 SPK--------VEPFAGSSIGGlesndpstntndnmykcrpSRHLLYATHFPLP-LDEEtTSH--DCNQRHVLL 791  pea aphid
EDO45182      493 -------------------------------------------------------LDQGdAEGclDPDQAQSLH 511  starlet sea anemone
3_pfamImport  394 NPDgnniagg-------------------------vwghgqPRHVQYLMHFPIPfQDDGiTQ---EWNQRLMVL 439 
XP_014344111  697 ---------------FSSTYDL-------------------PRHLQYATHFPIP-LDDS-SSH--ECNQRVILL 732  coelacanth
1_pfamImport  433 --------argSRGTLGRVYNQ-------------------KRNKGFTVHFSVF-QDES-SSH--ECNQRTVLL 475 
Q8BQM9        695 ---------------FPSNYDL-------------------LRHLQYATHFPIP-LDES-SSH--ECNQRTILL 730  house mouse
Q2QCI8        715 ---------kgMDPAFPLVYEQ-------------------PRHIQYATHFPIP-QEES-ASH--ECNQRLVVL 756  zebrafish
XP_008119976  717 --------draADGLLASLYDQ-------------------PRHIQYSTHFPIP-QEES-SSH--ECNQRLVVL 759  green anole
Q7YQK8        562 --------kekIEGTLGILYDQ-------------------PRHVQYATHFPIP-QEES-CSH--ECNQRLVVL 604  chimpanzee
Q16ZB3        757 SPKdpehtaphANTVNNKSESS-------------------SRHFLYTEHFPLC-QDDPiSQH--DCNQRYILL 808  yellow fever mosquito
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