Conserved Protein Domain Family
BMT

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pfam12141: BMT 
Beta-mannosyltransferases
This entry represents a group of fungal beta-mannosyltransferase that are involved in cell wall biosynthesis. For example, in Candida albicans, BMT1-4 enzymes act stepwise to add beta-mannoses on to cell-wall phosphopeptidomannan (PPM). While Bmt5 and Bmt6 are involved in the addition of the first and third beta-mans to phospholipomannan (PLM), respectively. Furthermore, in Saccharomyces cerevisiae, BMT5 and BMT6 are responsible for methylation of uridine residues in the 25S rRNA.
Statistics
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PSSM-Id: 403385
Aligned: 50 rows
Threshold Bit Score: 509.042
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6BT15       124 KCEAkLQSTSVIEIDKAKNIGVSLPEILTNFLKEc--eTNPYYKELSPFFIDELKLQLKFNVVEKYWYRLAGSSVWLEQY 201 Debaryomyces ha...
CCE40237     132 MCSE-LEYEDAFDVTKQAYLDSDFEYFMTKFKQIk--eYAKLLKKAKAKFKPVIPE-------HKQWFRFGGSSVWLSQF 201
XP_001527259 152 MCSE-LEFEDSFEHTGQAYLNANLALLLNKINGIe--eYKNLIQQAKKRFRPTIPE-------QKQWFRFGGSSVWLPQF 221
XP_007376341 123 MCRN-ILFEDSFEVSEQSYLNANHEIFMNELNKNv--eFVNILKQAKDKFKPTIPE-------EKQWLRFAGSSVWLPQF 192
Q5AEC6       131 iCSEkLMFPSKIKLTKQQYLPADLQQFLGVLNNMr--pYHDMVEKAKAYFISDLRE-------EKKWFRFAGSSIWLPQF 201 Candida albican...
EMG46220      96 ICQV-LNFEDSFDVSQQDFLDFDLDMFLNKLRQMk--aYYGIVQQAQDYFVSDLAE-------HKKWIRFVGSSLWLPQY 165
XP_004198562 128 KCEK-SHMVKEIGVGRTVESKVALREVLYRFLNEy--eNNAYYDEVSPFFMEHLADQLRSNLFDNSWFRLAGSSIWLEQF 204
XP_002546906 101 QCGL-LESKNTISINKPIDMKVSLFKILSKLLYDm--kDDEYLKELQPFIIPELLIQLKLNIIDKFWYRFSGSAIWLDQY 177
CCE43544     119 QCNR-LQLNSSVMISKAVNMKTPLREVLQNVLNDiesgESAYLAGLKKIILPELRLQLDLNVVDKFWFRLAGSSVWLKDY 197
EDK42946     130 RCHE-IKQELNMFIDKAIDMKTPLDKVLEHLLKElqhgSNPYFEDIQDLILPELKLQVHLGVVDKFWFRIAGSSTWLEDF 208
Q6BT15       202 GVHFMISRILYSPKGARNQPIISLTYAQIFSKDWKELTN-TKLIVPTNYIEGMEdte--------vidD-QRFEaLKFPY 271 Debaryomyces ha...
CCE40237     202 KVHYMVSRVLYSPSGIANKAYVSFLYVQLFDQDWKELPKgTNLTIPFEKSDSTNwmnldgsvttirgdPqLRYKrVEFPH 281
XP_001527259 222 KVHYMVSRVLYSPQGVPNKAYVSFLYIQIYDENWQELPQgTKLTIPFEEVKVKYqgnydgsftksgaeSkLGFReTEFPQ 301
XP_007376341 193 NCHYMVSRVLWTPTGIPNKAFASFLYIQLFDTNWQEIPT-MSLEVPFEEQVLKKglrsdgtfdemimsKiLNFReQTFPY 271
Q5AEC6       202 QCHYMVSRYLYSPNGVANHAFASFLYIQLFDSDWKELPShTTLDIPFEQTEANSifkif-----kpkqKyANFRnSTYPQ 276 Candida albican...
EMG46220     166 NCHYMVSRILYSPNGIANYGFVSFLYIQLFDTDWNELPP-MKLEIPFEDSIVKEssqyggwvsnveesHfLNFRtVEFPH 244
XP_004198562 205 GVHLMISRVIYTPKQSRSQPSLSLTYAQLFTKDWKELVD-TRLVVPTNDPENPYgd-----------sD-DNYRvIKFPC 271
XP_002546906 178 QVFFMISRIIYSPKGIKNQPVLSLTYAQIYDKNWNEIHG--KLVVPSNNLNKQQq------------qQ-ESFKdLTFPC 242
CCE43544     198 GVHYMVSRIMYSPKGTRNSPILSLSYAQLYDENWNELVG-TRLLLPKAHNSPT-----------------GERHiLNFPQ 259
EDK42946     209 GVHYMISRVLYSPRGIRSRPIVSLTYAQIYDKDWNELVG-INLVIPPIKNGTHVeene------gkatK-KNFRlMEYPR 280
Q6BT15       272 FLPIPFWHDYDNVE-HKYYGPEDPRILLVKNTKGYLEPLIIFNAYHRKLSRYDDDEDDGLVLKQDFYRSMFMSWPWQFQK 350 Debaryomyces ha...
CCE40237     282 ILPIPIDYAMQTENeKYYYGPEDPRIILRENPLGFEEPLIVFNMKELKIVK----------------RIMFLYLPFS--- 342
XP_001527259 302 ILPIPFDYSLKTEKnKYYYGPEDPRILLHENPLGFEEPLIVFNMKDLKIEK----------------RTMFMYKPFS--- 362
XP_007376341 272 ILPISFDYQLDVPNgKYYYGPEDPRVVLRANPLGFDEPLIVFNMKDLKLVK----------------RVMHTYLPFS--- 332
Q5AEC6       277 ILPIPFDYKLPIETkKYYYGPEDPRILLRSNPLGFDEPLIVFNMKGLKLTK----------------RVMYSYLPFS--- 337 Candida albican...
EMG46220     245 ILPISFDYETGSGSkNLYYGPEDPRIVLRTNPLGFEEPVIVFNMKDLELRK----------------RVMHLYLPFS--- 305
XP_004198562 272 FLEIPFWHDYSNTN-NKYYGPEDPRITLVKNKKGYEEPLIIFNAYHRKL----MKDEKSGEVKPAFFRSIFMCLPWQRQK 346
XP_002546906 243 FLRIPFFHDYDQTS-GKYYGPEDPRLTLV-NVNGYEEPLIIFNSYNRKFIDADDDEDIGLGKEIKFFRSMYMCYPWKFQL 320
CCE43544     260 IVPIPFWQDPEINE-DQYYGPEDPRLILIKNEGGYDEPLILYNSYNCKMDTYDDDEDEKLVTTQRCYRAMSICWPWQFDE 338
EDK42946     281 FVAIPFWHDVDQFD-NRYYGPEDPRLILVMNEHGYEEPLLVYNSFYVDMRPYDDDEDLGEPKTQEFFRTMFICWPWQLGE 359
Q6BT15       351 GKPNTDGMGNkEFDDKLYNKAIELKIKNIP-RQKKQKNWTPFISDNLRTIHG----YDKFVNFVYRWANFEVLKCDLIDd 425 Debaryomyces ha...
CCE40237     343 ------------------KTLNLLKKRTDK-YAKIEKNWTPFISPNQKSQN--------KLNFIYSIVPLEVLVCEID-- 393
XP_001527259 363 ------------------NILKLLKKRNEK-YAYVEKNWTPFFNPVLAKKD--------QINFIYTIVPLSILTCNVQ-- 413
XP_007376341 333 ------------------NKMQVLRKRTEK-YANIEKNWTPFISKIKSVNDnqqepGDLKLNFIYSIMPLEVLVCEID-- 391
Q5AEC6       338 ------------------NTLKLLKKRREP-FANIEKNWTPFKSVAQPSKT------QTTIHFIYSMIPLEVLACDID-- 390 Candida albican...
EMG46220     306 ------------------NHLTTLTKRKES-FSHIEKNWTPFFDSPNGPHR--------KIRFIYSIEPLEIVECDIH-- 356
XP_004198562 347 GKTNVDDDEDsEYKNRIYSKVTELRVVNQK-RREIQKNWTPFITYSKRAEKG----YDETVDFVYSWSNLEVLRCGLTQn 421
XP_002546906 321 DKSNVEGISTqEYNDHIYNKIIEFKIKKYEtSFSNQKNWTPFISSSDKSK----------IKFVYRWTNLDILSCDLT-- 388
CCE43544     339 QKN---------------SKRVELKLENY--RLRTQKNWTPFTSPLDRQVDG----YDSHIYFVFRWANLDILKCDL--- 394
EDK42946     360 DK--------------VHNKVVELKIENSE-PMRAQKNWTPFISFEDRNEVG----YDRHINFVFRWANLEVLKCTL--- 417
Q6BT15       426 SGSCSFTYRLNHriSTESQVGPLRGGTELKNI--NDLIRTqtdlPLEKLL--PPH-REIWVGFARAHLDKCGCGNNMYRP 500 Debaryomyces ha...
CCE40237     394 TAVCDFLQNPKK--KKKNFVGALRGGTQLVSLplDK-LPT----AVRDSLhiPAN-RNVFLGWARAHLNKCGCGESMYRP 465
XP_001527259 414 LGICDYLQKGAK--KNFNYVGALRGGTQLVPLplAD-LPA----SLKSQLavPKN-RQIYLGWARAHLNKCGCGESMYRP 485
XP_007376341 392 TAVCDFLQKPEK--DDYDFVGPLRGGTQLVPLplSDILPA----SIKEKFtlPDN-RQIYLGWARAHLNACGCGESMYRP 464
Q5AEC6       391 SGLCDILQKPAK--HDFNYVGGLRGGTQLVSLplNETIPS----EIRAKLpiPKN-RQVYIGWARTHLNNCGCGDSMYRP 463 Candida albican...
EMG46220     357 SGVCDNLQTQYK--NDKNFIGDLRGGTQLLPLpiDDFLPD----SMKPYFksLEN-RKVYIGWAREHLNQCGCADAMYRP 429
XP_004198562 422 PGECKRVFRAK---SDDASVGPLRGGTELVSL--NELLSHqskfPSEKII--PKG-REIWIGLARTHLNGCGCGSAFYRP 493
XP_002546906 389 TGFCEFEYKMNKtlSPKNKVGPLRGGTQLVNL--SDIIP------DKSIL--LPT-REIFVGFARTHLDDCGCGKTMYRP 457
CCE43544     395 QGSCSYDYRFNTslSPKNQVGPFRGGTQLVNL--NDLVT-------------VKDnKEIWVGFARAHIDDCGCGSSMYRP 459
EDK42946     418 DGSCHFEYRFDEslSVKNEVGPLRGGTQLFNL--HSIIP-------------FNSdKEVWVGFARAHIDYCGCGKAIYRP 482
Q6BT15       501 NMVVLVKDSIstkkdvkdpkspkvikdFYKISHISSSISLDIPIIGWDleNPRDV---------------CIGSNILIPN 565 Debaryomyces ha...
CCE40237     466 NMIILIEDYNeet-----------gkyYYKLGDVSDYIDFGAYVPPWVspKIDPKsgqlie----aeplpCEGRNVLIPN 530
XP_001527259 486 NMILLIEDYNadt-----------ntyYYKIGDVSSYFDFGAYVPPWTlpKKDTKtgqmlfpgddfaprhCEGRNVLIPN 554
XP_007376341 465 NMIILVEDYDatn-----------dkfFYKLGDVSEYFDFAATVPPWVtpKLDDQgnliee----eypkqCEGRNVLIPN 529
Q5AEC6       464 NFITLVEDYDdvt-----------dkyYYKIGDISGYFDFAAKIEPWSkqVLDEEgnlye------kaeqCQGRNVLIPN 526 Candida albican...
EMG46220     430 NMITLIEDYDpkh-----------nkyYYKIGDVSSYFDFNSVITPWIvlEADDDgnite------skhlCIGRNVLVPN 492
XP_004198562 494 NLVILVKDDPanipgsed-sdfalmedFYKVSHISSSISFNVPILGWDinKPQDL---------------CSGSNVFIPN 557
XP_002546906 458 NLVILVKDIIdd-------------qiYYKVSHISPSLSFDIPIPGWS--EPDDL---------------CYDLNILIPY 507
CCE43544     460 NLVVIVKERKdl-------------rnHYKVTHISSSLSFNMYVPGWDllYPENS---------------CLRSSVLIPN 511
EDK42946     483 NLVVVTKETVdt-------------esHFMVTHVSSSLSLNVSVGGWDlqTPEAR---------------CFRSSILIPN 534
Q6BT15       566 GISSWNIKSIRena-------------------------------------ktgFFETDDYMTLSLSISDFTVHTINIKG 608 Debaryomyces ha...
CCE40237     531 SIAYWDIESVTrdgktlkn---------------------------fdqltsldSVSINDYMGVTLSAADQDVSIVHLRG 583
XP_001527259 555 SIAYWQIKSVTtnngrktien-----------------------yqdsafalssTVSFNDYMGVTLSAADQDVSIVHLKG 611
XP_007376341 530 SIAYWDIAGIIkdnilyprkffhriptdeeiadkkaakvmkqkagsfkrsnifgDVIINDYMGVTLSAADSDVSIVHVKG 609
Q5AEC6       527 SIAYWDVGSIKlagteyqkhdfkd-----------------mfssgkvsdfnanEIVFNDYMGVTLSSADRDVSIVHVKG 589 Candida albican...
EMG46220     493 SIAYWDIESVIyddvsytrdklt-------------------glgkfpdgttkdSFFFVDHMGITLSSGDRDVRIVHLRG 553
XP_004198562 558 GISYWWIKNIKed---------------------------------------qgSFKTDDFMTFSLSLADYTVHSVDVKG 598
XP_002546906 508 SISKWDISSLKki---------------------------------------esNYKVKDELILTLTISDETIHKLNIRG 548
CCE43544     512 GISQWITHKDSs------------------------------------------GALIDDYLTLTLSVSDYTIHRVNVKG 549
EDK42946     535 GISQWNVEKDPq-----------------------------------------sNAILEDYLTITLSITDFTVHRINIKG 573
Q6BT15       609 LLNQILnlndkslfmpidsdsedesfstniknlnipdAsIVDDPRRNNLLWLTGYNNDNVLCALDSSAKF 678 Debaryomyces hansenii
CCE40237     584 LLNYIIkl---------------------------psLfDESTAVYNRDQFNIRGSDWNYKCAMKASKEY 626
XP_001527259 612 LLNYIVkl---------------------------psLfDEETVVLSDTNFGIRGSDWNNKCAMYLSHRY 654
XP_007376341 610 LLNYILkl---------------------------psLfEDSSVIDNDSIFQQRGYDYNNKCAMQASDDY 652
Q5AEC6       590 LLNYILql---------------------------psLvDDSLVINKEWTFQKKGHDLNVRCAMIASKEY 632 Candida albicans SC5314
EMG46220     554 FLNYLFql---------------------------psFsNSDLIVNTHNEFQVYGFDMNVKCAKWVNKEY 596
XP_004198562 599 LLNAILqlddktl-----------------fnsaeksNdAYGSEANVIPPSRFYHNNVNIQCAIDKSMEF 651
XP_002546906 549 LFQSILnlndnslf----------------kipssnpKlPSSSKSTDSHLKYLGYNNDNLMCALKGSDEF 602
CCE43544     550 LLKELIn-----------------------------wG-----VLDYDVMASTHHANDNLVCALQSSFEF 585
EDK42946     574 LLKEIIn-----------------------------lG-----VLKSHQPAWFMASNDNIVCAIQAATEF 609
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