Conserved Protein Domain Family
Phtf-FEM1B_bdg

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pfam12129: Phtf-FEM1B_bdg 
Male germ-cell putative homeodomain transcription factor
This domain is found in bacteria and eukaryotes, and is typically between 101 and 140 amino acids in length. Phtf proteins do not display any sequence similarity to known or predicted proteins, but their conservation among species suggests an essential function. The 84 kDa Phtf1 protein is an integral membrane protein, anchored to a cell membrane by six to eight trans-membrane domains, that is associated with a domain of the endoplasmic reticulum (ER) juxtaposed to the Golgi apparatus. It is present during meiosis and spermiogenesis, and, by the end of spermiogenesis, is released from the mature spermatozoon within the residual bodies. Phtf1 enhances the binding of FEM1B -feminisation homolog 1B - to cell membranes. Fem-1 was initially identified in the signaling pathway for sex determination, as well as being implicated in apoptosis, but its biochemical role is still unclear, and neither FEM1B nor PHTF1 is directly implicated in apoptosis in spermatogenesis. It is the ANK domain of FEM1B that is necessary for the interaction with the N-terminal region of Phtf1.
Statistics
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PSSM-Id: 403376
View PSSM: pfam12129
Aligned: 20 rows
Threshold Bit Score: 203.686
Threshold Setting Gi: 765550571
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001961292           3 LDEIVEWYQKKIGTYDKQEWEKTVEQRILDGF---NN-VNLKNTKLKTELIDVD--LVRGSTFPKAKPKQSLLTVIRLAI 76   Drosop...
XP_015783754           8 FRDALHWYQKKIGSYDQQVWEKSIEERVLRGL---SHaIPKKVARVKKESIDLDldLIRGSYFAKAKPQQSWLTTTYLGI 84   two-sp...
KJE91192             718 IDSSVSAFQAKFARYDSATWERQLER---QGSqpqT--TRKSKSQPKPELIDLD--LVRGSMFFKAKPTEADSNILRKGF 790  Capsas...
Q16RV6                15 LDELVAWYQKKIGTYDKQQWEKTIEQKILAGI---NH-LPLKNTKLKTELIDVD--LVRGSTFPKAKSKLSILTVIYLAA 88   yellow...
WGS:AANI:GJ22176-PB    3 LDEIVAWYQKRIGTYDKQEWEKTVEQRILDGF---NS-INLKNTKLKTELIDVD--LVRGSTFPKAKPKQTLLTVIRLAI 76   Drosop...
XP_016839289           3 LNKLVYWYQKKIGTYDRQEWEDTVEQKIFCGL---TH-VPMRAAKLKTELIDVD--LVRGSSFPKAKPKHGLGTVVYLAI 76   jewel ...
EGI62974               3 LNELVHWYQKKIGTYDKQQWERTIEQHILDGL---TH-VPMRTTKLKTELIDVD--LVRGSSFPKAKPKHGLLTVACLAF 76   Panama...
XP_002424422           3 LQDLVSWYQKKIGTYDKQQWEKTVEQRILHGL---TH-VLKKTAKLKTDLIDVD--LVRGSSFPKAKPKHGLITVTKLAL 76   human ...
EEZ98518               3 VKDLFTWYQKKIGTYDKQKWETTIEQKILYGL---TH-VQMKSTKPNTDFIDLD--LVRGSSFSKIKPKQGFMTVAKLAT 76   red fl...
XP_008181443           5 VQKIVTWYQKKIGTYDKQQWEKTIEQRILSGF---TH-VPKKNAKLKTDLIDVD--LVRGSAFTKTKPKHGFFTVARLAI 78   pea aphid
XP_001961292          77 LRYVLLPLYAQWWVKQTTPNAFGFILVLYLTQLLNWAIFVLHTSRLvplgydnasnsslfagrpagdgeeltgdrtadkq 156  Drosop...
XP_015783754          85 VRILLFPFYLNWWTEQTNSLICAILFILYCLQMISMYIYFNSEKDD---------------------------------- 130  two-sp...
KJE91192             791 LRAVFFPLFRTWWCEEVHFNAWLVGTLMYLMQISSVLLYMLDGEVAqltnaeesea----------------paaiddsl 854  Capsas...
Q16RV6                89 LRLLLLPIYAKWWVQQTSPRVFVLLLALYMLQMINLGIYSYNVNKTgad------------------------------- 137  yellow...
WGS:AANI:GJ22176-PB   77 LRYLLLPLYAQWWVKQTTPNAFGFILCLYVTQLINWAIYIMHSNRLaplvydretnttvvd-------dvataavddkqh 149  Drosop...
XP_016839289          77 QRLLFLPYHAQWWIHQTSFRIYILFILLYGLQMLNLYIFFNYFPKEn--------------------------------- 123  jewel ...
EGI62974              77 QRLLFLPLYKKWWIQQTSYRIFVLFLLLYSLQTINICLYYVYTNREn--------------------------------- 123  Panama...
XP_002424422          77 IRWLFLPLYSYWWIEQTCFTIFTLLLLLYILQLCNVLVYFLNFD-Dq--------------------------------- 122  human ...
EEZ98518              77 FRCLFLPIYSKWWMQQTSVSIFTLMFCLYVSQLTNIAIYYKNSWTNqml------------------------------d 126  red fl...
XP_008181443          79 VRLLFLPCYYRWYIHQTSWRLFLSLLCLYVLELANILLFSYITFVStee------------------------------- 127  pea aphid
XP_001961292         157 aeEHADLLSALLIPCALSLLISLIHSQIVATNTA 190  Drosophila ananassae
XP_015783754         131 --FDEIPISEVVSPLFMFFILGTMQSQIGASSSS 162  two-spotted spider mite
KJE91192             855 spRLVVTPMEVFLPLSILLASGIVYARVAATRFT 888  Capsaspora owczarzaki ATCC 30864
Q16RV6               138 qeEHIVSMSEFLIPIALSLLLSVIHSQIVATGsh 171  yellow fever mosquito
WGS:AANI:GJ22176-PB  150 seESADLLSALLIPCALSLLISLIHSQIVATNTS 183  Drosophila virilis
XP_016839289         124 -eSDIITISEVITPAVMMLILCLVHSQIVSTNsg 156  jewel wasp
EGI62974             124 -eAEIISMSEVLVPVVMMFVLCTVHSHIVSTHSg 156  Panamanian leafcutter ant
XP_002424422         123 -lFEHVSTYEVLVPIGMMLVLSIIHSQIVSTNNi 155  human body louse
EEZ98518             127 ksPENVMCMELIVPFLMTWVLSLVHSQIAATMpv 160  red flour beetle
XP_008181443         128 dtPPTVTLGEVLSPFIMMLVLSIVHSQIVSTTTi 161  pea aphid
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