Conserved Protein Domain Family

pfam12107: VEK-30 
Plasminogen (Pg) ligand in fibrinolytic pathway
Pg is an important mediator of angiostatin production in the fibrinolytic pathway. Pg is made up of five subunit kringle molecules (Pg-K1 to Pg-K5), of which the first three make the protein angiostatin. VEK-30 is a domain of the group A streptococcal protein PAM. It binds to Pg-K2 of angiostatin and activates the molecule to mediate its anti-angiogenic effects. VEK-30 binds to angiostatin via a C terminal lysine with argininyl and glutamyl side chain residues known as a 'through space isostere'.
PSSM-Id: 152542
Aligned: 8 rows
Threshold Bit Score: 1e+06
Created: 21-Apr-2021
Updated: 29-Sep-2021
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Q7M153  68 DEVALERLKNERHVHDE 84  Streptococcus sp.
Q6V9Q3  84 ADVALERLKNERHVHDE 100 Streptococcus pyogenes
Q8GLB0  97 DD-ELERLKNERHDHDK 112 Streptococcus pyogenes
O50278  98 DD-ELNRLNEERHDHDK 113 Streptococcus pyogenes
Q8GL84  89 DA-ELKRLNEERHDHDK 104 Streptococcus pyogenes
O68619  98 DDAELQRLKNERHEEAA 114 Streptococcus pyogenes
Q5TIP1  80 RDAELKRLNEERHEEAE 96  Streptococcus pyogenes
Q54898  93 ADPELQRLKNERHEEAE 109 Streptococcus pyogenes
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