Conserved Protein Domain Family
Gcn1_N

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pfam12074: Gcn1_N 
Domain of unknown function (DUF3554)
This domain is found in the N-terminal region of Gcn1 protein, which acts as a translation activator that mediates translational control by regulating Gcn2 kinase activity.
Statistics
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PSSM-Id: 403336
View PSSM: pfam12074
Aligned: 82 rows
Threshold Bit Score: 229.819
Threshold Setting Gi: 146413827
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPB90099      379 EHRVIMYNALSSLAQatEPVVSQKSLEGYFTMIAKEAHEQAMAAAVDGVGRHLTVLIYNdefcsaNKEFVDKVVKTSTDG 458  Mucor circine...
CCA74203      243 DHRQALYSMIPNIPS--RDDLCVDVAGTTFALWEKETSEVAISTLAEASSSHLADLLRR------GTALGDKTESIIVKE 314  Serendipita i...
EGO00628      410 DHRVALYSMLHALSP--SNAISSNIVQIVPTLVLKESQDGAMAILASTLPSHLVFLLRS------DIAVPSDVSSIIAKE 481  Serpula lacry...
EKM81347      393 ENRIALYSMLAFLQP--GTEVSSTLVEAAIPLLAKEQNEVATAKLATSLGPHITFLLKF------DTDKLKDVTPLIVKD 464  Agaricus bisp...
XP_001829939  416 EHRVALYSMLGYVRP--SNDVSPVLIQSSTPLLAKETNEAAIAVLANALPPHITFLLRS------STALPSEAVQLIAKE 487  Coprinopsis c...
EDR07731      382 DHRVALYSMLSFLGA--GSGVSSSLVESTIPLLAKETHEAATAVLAAALPPHIVFLLSS------ST-LSPDVIQLIAKE 452  Laccaria bico...
XP_007398289  419 DHRVALYTMLGYLPP--SQEVSPTAVEAGPSLLAKETNDGAITVLALSLARHIVFSLCE------NLALPVATQTAITKE 490  Phanerochaete...
EMD33195      394 DHRVALYSMLGCLTP--SPAISLTVVQSALPLLAKETHDAPIPLLRSALSSHLGFCLRN------STVLSTDSVVVLAKE 465  Gelatoporia s...
EED82641      419 DHRMALYSMLGFVRP--ATSASTAIMQTSLPLLAKETHDGAISVLTSALVPHLVFCLRE------NIVLPGDAVSVITKE 490  Postia placen...
EPS96603      419 DHRVALYTMLGTVKP--SP-ASVAILEAGLPLLAKETHDSAVSALAASVTPHLSHCLHE------DLPIPSDIMAILAKE 489  Fomitopsis pi...
EPB90099      459 LNAAKPLARKSWANAVGTTVWDHKD--------ATSAtlSA--NIVKYLQALFKTFNKIVDKPL-MWKDGPV-EAYVMIS 526  Mucor circine...
CCA74203      315 AASVKPAQRRAMLTLIGEAFWALH-----------TGgdSQseSASALLKKLESGLLKLLKDASiSTVVQGVvDHWIALL 383  Serendipita i...
EGO00628      482 MNNTKPVIRRAFCLLAGATLWEMGE--------LSTDasIV--FAKALSASFEINLKNVATNPLnSTVGPL--EGYIAIF 549  Serpula lacry...
EKM81347      465 MNSVKPAVRRAFVALAGDIFYEESSv------sLEDEkaVV--FMKALLSAFETSLKNVSGNVLnNPAGPL--EGYIAVA 534  Agaricus bisp...
XP_001829939  488 MGSLKPPVRRAFATLVGSVFYEDEGdgegkgvvGESEagKA--FAKAVAPSLENALKSVAANPInAPGGPL--EGYVALA 563  Coprinopsis c...
EDR07731      453 MSSAKPAVRKAFAGLAGAIFFHEADi-------ISKEngVA--FAKIVVHSFENSLKTVSGNPLnSPGGPF--EGYVALA 521  Laccaria bico...
XP_007398289  491 MNAAKPPVRRAFSSLVGNVLWELDN--------LSTQaaLD--FAKAVLPSLETSLKTVAASPAaPPAGPL--EGYIAVA 558  Phanerochaete...
EMD33195      466 MNNTKPMIRRAFCSLVGDAFWDLED--------LESEatVT--LAKALLPAFETNLKTVSASPLtAPAGPL--EGYIAAA 533  Gelatoporia s...
EED82641      491 LMGAKPVIRRAFCSLVGDAFWQLEV--------LHTEvsLS--LAKAVLPALDTNLKTVAAAPLtSAAGPL--EGYTAVA 558  Postia placen...
EPS96603      490 MTSAKPVVRRATCNLVADAFATLRLi------eQPSSaaET--LGRALLPAFETNLKTVASSPLtAPAGPL--EGYTAVA 559  Fomitopsis pi...
EPB90099      527 IISGRIQHWPtvpePVADLLKTQK-YPSQVLISQPKPSYLLWDRIYTKALTAEEGLWLVRALTSVFMEETQDSLeKTGAG 605  Mucor circine...
CCA74203      384 LVLRQTGSS-----------THSStLLQGILFPSGKPSFLYSEKNYQKVDDPKEAIWLLRVLDTLTTHSDDLVR-QEKAS 451  Serendipita i...
EGO00628      550 ALLGPFKRSG----SFDDIVSRNT-SAQSLTGTPTKPSFLLWDKVYQKVNDPEDENWLLRAANVALFSLKADLSkNEQSR 624  Serpula lacry...
EKM81347      535 VLLGPLHHLG----RFDDVISKNA-VIGAIATSTVKPSFLLWEKVYQKATEEVDEMWLLRALKVSLRYFKKELVkNEVLR 609  Agaricus bisp...
XP_001829939  564 TLLGPFARSG----IFDELISKNA-VVQAIVASSAKQPFLLWDKVYQKVTDPADEKWLLRAANAAFKHFHSQIAkSEGLK 638  Coprinopsis c...
EDR07731      522 VLLGPLSRSG----KFDDVISRNP-VVSAIVTSTAKQSFLLWDKVYQKITDAEDEKWLLRASEAALHHFKADLGkNEALR 596  Laccaria bico...
XP_007398289  559 LLLGPYHRSG----KFEDFISRNT-SSQSLLATGAKPSFLLWDKVYQKLVEPEDQAWLLRAGEAVLSYYKNDILkSEQTS 633  Phanerochaete...
EMD33195      534 VILGKLARCS----AFDTFVSQNT-LVQSLMTVGTKPSFLLWDKVWQKVSDVEDERWMLRASIAALAFFKPQLArNEQAR 608  Gelatoporia s...
EED82641      559 VLLGPFSRSG----NFDDVIAHNA-TVQSLMTAGSKPSFLLWDKVYQKLNGEDDEKWLLRAAQASLAFFQRELLrNKQAC 633  Postia placen...
EPS96603      560 TLLGRISASP----GFGDFIARNS-TLQSILTAGAKPSFLLWDKVYQKLGSLEEENWLLYAAEATLLYFNKELSqNEQAC 634  Fomitopsis pi...
EPB90099      606 HLAAQALVWIIASHPDHTVRRSAYQEVSSMAASEPIKLDHFMKQAIKQWLLDI----ENNVKDSTAVSAVNADNYnket- 680  Mucor circine...
CCA74203      452 LYFGQTLLWLAVDHPSPTIRRETLSTLKRLSAAIPVPISNAINLASNNLLFGDskqaKEEESSPHRSLRLSAA------- 524  Serendipita i...
EGO00628      625 TQIGSVYLHLAVESQSLQVRRDTLGVLEAAVTRQPQLVNLILREALSASFTRD-----KLLPSKSTISTTEEQDQpiap- 698  Serpula lacry...
EKM81347      610 INFGSALLHLAVESTRKDTRQATNKMISEAAVWDPHLTTTLIRESVVASLCRA---------SSTKTTTGEDAPAlkk-- 678  Agaricus bisp...
XP_001829939  639 VQFGLVFVHLAVESKSPENRKLVNEYIVGLATAYPQLTNTVIREAVTSFVSAT----------SSSSTSSPSPPStvppk 708  Coprinopsis c...
EDR07731      597 SQLGLIFVHLALNGQSPDLRRSVYNVVEAATAEAPELTNSVVRDALTTFVSRG-------LPNPKSSTAGDEQPSalwn- 668  Laccaria bico...
XP_007398289  634 AMVGNLFLHLAVDGSSVEIRRLAVSSMNAQAPKLPEVVNRIVSASLKAYLVKE---------SAPARTSGEEAETkvvs- 703  Phanerochaete...
EMD33195      609 GALGMSLLHLAVASSSPNIRRLVVKALEEQSSASPELVNNAITAALTSYLTKE-----VATPSKLANRDGEESAPdsgr- 682  Gelatoporia s...
EED82641      634 AMIGMVFLHLVINSPLPQTRRETLKTLEESVAQLPEVASVAIVSALSAYVSKE-----KASSAKVQNGSSEENEPkvnr- 707  Postia placen...
EPS96603      635 AMIGMVFLHLVVSGQHQLVRRRTLATLEASAALFPEIVNQAAISALSSFLSND--------KSSSATSSSEETSStshl- 705  Fomitopsis pi...
EPB90099      681 ------------atfrLAAVLNAITSYDKDLAESTKGVELIDMMILAHHEYIAsptnRY-NWITLVQRANVDPGKLVREK 747  Mucor circine...
CCA74203      525 -------------------LLSSA--NLANQVEEVKEKLIVDLFLVSHHPVLSr--aGEaLWIELAQHAQLDPHLVVTRH 581  Serendipita i...
EGO00628      699 ------------nqrqFASLLLCCASLNEQVDLAVRETLLVELIALGHHPLISgq-sRQ-LWIELCQKAHVDPYDLVGRN 764  Serpula lacry...
EKM81347      679 -------------hsrLASVLLSSNTYDGDVDMELKEELVTELIVVGHHEFVSgp-lRQ-TWIDICQKANIDPKALIEKH 743  Agaricus bisp...
XP_001829939  709 tepeeaglqgwnkhgrLSGLLLSCSAFDESVSGLEKEGLVAEWVVVAHHPLICgp-sRQ-TWIDLCMKAGVDPLVVANKH 786  Coprinopsis c...
EDR07731      669 ------------khsrLSALLLSVVAFKDDVDPSIRESSIVKLIVLGHHSLICgs-aRQ-TWIDLSQKAGTDPHDLTNKH 734  Laccaria bico...
XP_007398289  704 ------------kegrLCAFLISCAAVGQDVDCSVREDLVLDLLVVSYHTAIAghglRT-PWIDLCQTAGVDPHEIATKH 770  Phanerochaete...
EMD33195      683 -------------enrLSAVILSCGAMPADYDQDLKAQLMIKFVILAHHSAVCgk-sRQ-TWIELCQKAGVDPHDLVYQY 747  Gelatoporia s...
EED82641      708 -------------egrLSAFLLAAQAFSEECDSATRKTALVRCVVLAHHPALGvg-sRQ-IWIEACQKGRVDPLNLVVER 772  Postia placen...
EPS96603      706 -------------gdrLAVFCLASFASRGSCEEQARKSSLVNFVVLAHHPAVGgk-sRQ-LWIDLCQKARIDPHDLLSER 770  Fomitopsis pi...
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