Conserved Protein Domain Family
SCAI

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pfam12070: SCAI 
Protein SCAI
SCAI is a transcriptional cofactor and tumor suppressor that suppresses MKL1-induced SRF transcriptional activity. It may function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1.
Statistics
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PSSM-Id: 403333
View PSSM: pfam12070
Aligned: 33 rows
Threshold Bit Score: 649.328
Threshold Setting Gi: 75111538
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q54YY1        67 HLLRKSQRLFIGLRDLPQFG-RQ-WQPFFQKTFELYTKLWKFQQQYRSILEDKskyGLKRCEIGEIASKIGQLYYHYYLR 144 Dictyostelium d...
Q94BN1        12 ALVENADRKFARVRDLPAFGrAQ--SHYFQKVFKAYMKLWNYQQSHRSKLVES---GLNRWEIGEIASRIGQLYFSQYMR 86  thale cress
XP_004957070  14 ALAEAADRKFARARDLPLYGgGD---HHSRKAFKAYTRLWRLQQERRRELVAG---GLRRWEIGEVASRIGQLYYARYLR 87  foxtail millet
XP_006838589  13 SMCNKADRKFAKSANLPLYGkIN-HASSFKKVFKIYTKLWKYQQDHRQKLIED---GVKRWEIGEIASRIAQIYFTQYMR 88  Amborella trich...
XP_006576669  35 TLVDKADKKFSKIRDLPFYQrSR-HDTYFYKVFKVYTQLWKFQQENRQKLIEA---GLKRWEIGEIASRIGQLYFGQYMR 110 soybean
EEF38372      33 SLVERADKKFSKIRDLPYYErNR-YDTYFYKVFKVYTQLWKFQQENRQKLIEA---GLKRWEIGEIASRIAQLYYGQYMR 108 castor bean
Q5Z480        35 SLLDKADRRFARVRDLPLFGrRE-PDEY-GKVFRIYTQLWRMQQEHRHRLLDA---GLRRWQVGEIAARIAHLYYSQYQR 109 Japanese rice
XP_009134734  18 SLVNKADKKFSKIRDLPFYErSR-YENYFFKVFKVYTQLWKFQQENRQKLVEA---GLKRWEIGEIASRIAQLYYGHYMR 93  field mustard
XP_009380875  19 SLVEVADRKFARVRDLPPTArGAlHLLHCRKAFKAYTRLWQFQQQRRRELVAG---GLRRWEIGDIASRIGQLYYGQYQR 95  wild Malaysian ...
XP_009388060  19 ALVDGADRKFALVRDLPPGArGPlQLLYFRKAFKAYTRLWQLQQRRRSELVSE---GLCRWEIGEVASRIGQLFYGQYQR 95  wild Malaysian ...
Q54YY1       145 TSDTNYLNESYIFYEAIRLRSYFKDVSLDK------TPDMMV--KQLRYYARFIVVCLLLNKK-KVVFDLIEELLKHVND 215 Dictyostelium d...
Q94BN1        87 TSEARFLLEAFVFYEAILKRSYFDEAQ---------GKDLGArfKELRFYARFLLVSLIVDRK-QMLLHLADKLRLLVDH 156 thale cress
XP_004957070  88 TAEPRSLVGAYVFYEAIYSRGYFGAAAGAEgggggrHQALLIryKELRFIARFLVVAMLMRRA-EAVDHLAGRLRALVEE 166 foxtail millet
XP_006838589  89 TSEMNLLCESCRFYQAILEREYFKENS---------ASDLSVanKQLRCYGRFLTACLTLGKR-EMVHQVVNHMKSLLDE 158 Amborella trich...
XP_006576669 111 TSDANYLSESYIFYEAILTREYFKEGL---------FQDVNIanKQLRFLARFIMVCLVLNRR-EMVQQLVNQLKVLVDE 180 soybean
EEF38372     109 TSDAGYLSESYIFYEAILSREYFKEGL---------FQDLNLanKQLRFFARFLMVCLVLNRR-EMVHQLVNQLKLLVDE 178 castor bean
Q5Z480       110 TSDTALLSEAFVFYHAVLDRGYFLADA---------ADHLFAptKHLRFLARFLLVALLLARRaDTVPRLTTHIRTLLDD 180 Japanese rice
XP_009134734  94 TSDAGYLAESYVFYEAILTREYFKDGL---------FQDLNIanKQLRFLARFLMVCLVLGRR-EMVHQLVEQFRRLIDE 163 field mustard
XP_009380875  96 TSEVRFLLEAYVFYEAIVSRGYFEAARASA------APDLKLryKELRFQARFFIVALLLNRT-DEVRQLADRFRALVEE 168 wild Malaysian ...
XP_009388060  96 TSEVRFLLEAYVFYEAIMSRGYFQAAWGSV------APDLKLryKELRFHVRFLIVALLLNRT-DEAVKLADRFRALVDE 168 wild Malaysian ...
Q54YY1       216 YTKIYKPSDAQEWSLVLQEIFSFLQADQCATFSDTNQspsltnsgniinnnsnsnnnngehtNNTVQSHrlnhlnCPsp- 294 Dictyostelium d...
Q94BN1       157 SISNFRETNFKEWRLVVQEITRFIESDTNLTYLRPLR-------------------------YCAMLDS------YPas- 204 thale cress
XP_004957070 167 TKAAYPKTNFKEWKQVIQELGRFLKADGAYKGSRSLR-------------------------YDNLFDS------YPsn- 214 foxtail millet
XP_006838589 159 HKRNFQDFSYNDWKRMLIDINRFLKADTAFMNRRPLR-------------------------YSVVLDA------DPya- 206 Amborella trich...
XP_006576669 181 CKRTFQESDFKEWKLVVQEILRFLKAETAFMNIRPLR-------------------------YSLVLDS------HPdt- 228 soybean
EEF38372     179 CRRTFQETDFKEWKLVVQEIIRFLKADSAFMNIRPLR-------------------------YSLVLDP------HPds- 226 castor bean
Q5Z480       181 SKKTLQEADYKEWKHVVQEIARFLRADSPFINMRPLR-------------------------YSYAFDP------PPdt- 228 Japanese rice
XP_009134734 164 CKRTFQENDFKEWKVVAQEIVRFLKSDTAFMNIRPLR-------------------------YSLVLDP------NLdas 212 field mustard
XP_009380875 169 SKAAFPATNFKEWKQVAQEISRFLKADVSSKISRPLR-------------------------YNVLFDA------HPss- 216 wild Malaysian ...
XP_009388060 169 SKAAFSATNFREWKQVVQEISRFLKADAYFKIARPLR-------------------------YNVIFDA------HPss- 216 wild Malaysian ...
Q54YY1       295 pfPLESTQI-----LQQAILVGSQQNQIKFSEITLDMFRMTQSLEYEPmseakendmklkqqltalqqqqqqqaaeakek 369 Dictyostelium d...
Q94BN1       205 qtYLARFHAkklfkFRDALLASYHRNEVKYAEVTLDTYRMMQCLEWEP-------------------------------- 252 thale cress
XP_004957070 215 laSIARFHSkrvlkLKEAVLTSYHRNEVKFTELTLDTFRMLQCLEWEP-------------------------------- 262 foxtail millet
XP_006838589 207 lpSVSSIEGkralrLSDAILGSYHHNEVKFAELNLDLFRMLQCLEWEP-------------------------------- 254 Amborella trich...
XP_006576669 229 lpHVAAAITkrhlkLRDAVLSSFHPNEVKYSELTIDTFRMLQCLEWEP-------------------------------- 276 soybean
EEF38372     227 llHVVTrrn---lrLRDAILTSYHHNEVKFSELTLDTFRMLQCLEWEP-------------------------------- 271 castor bean
Q5Z480       229 lpTVPPTVKkrglvLNDAMLCSYYQNEIKFTDLTIDVFRMLQCLEWEP-------------------------------- 276 Japanese rice
XP_009134734 213 tpRAsrs-----lrLTDAILSSYHYNEVKYSELTLDSFRMLQCLEWEP-------------------------------- 255 field mustard
XP_009380875 217 fpYIARFHAnrvlrLRDALLASYRRNEIKFAELSLDTYRMVQCLEWEP-------------------------------- 264 wild Malaysian ...
XP_009388060 217 fpYISRFYTsrvlrLKDALLTSYHRNEIKLAEVTLDTFRMIQCLEWEP-------------------------------- 264 wild Malaysian ...
Q54YY1       370 NNGTDQqnttipsqplqqhlhhqqqqqqnGNg--------------sGIKKRNPHKYLLYRPTISQILLFLSYSFKELGD 435 Dictyostelium d...
Q94BN1       253 SGSFYQkkpveak---------engfvvdHTltsglidmnlaadmadPSLPPNPRKAILYRPTVSHLLAVLAMICDELSP 323 thale cress
XP_004957070 263 TGS-YQiaakelt---------engtvsdQSgpsglidihlsteisdGSLPSNPQKAIIYHPTVSHLLAVLATICEELSQ 332 foxtail millet
XP_006838589 255 SGSFYPkrlves-----------sesscgEAgaavpkrfsyieglvdHSLPPNPRKAILYRPAATQFISVLAAIWEDLAP 323 Amborella trich...
XP_006576669 277 SGLFYQssgs----------------klsQNgatgtsrisyiqdiadPTLPANPRKAVLYRPSLTHFIAVLATICEELPS 340 soybean
EEF38372     272 SGSFYQsnsi----------------kygQNggpgpsrinythditdPTLPPNSRKAVLYRPSITHLLAVLGMICEELPA 335 castor bean
Q5Z480       277 CGSFALtng------------------ysTRdesgqnhpnllkdlrdAALPPNPLKTILYRPSVTHFLTVLATKCEELPS 338 Japanese rice
XP_009134734 256 SGSLYQsagp----------------kmgPNaptgasrv-nsqnvtdPTLPPNPRKAVLYRPSITNFLALLATICEELPS 318 field mustard
XP_009380875 265 SGSSYQlfrkepy---------engafsdQSgasglidinlaadlmdPDLPPNPRKAVIYHPSVSQFLAVTATICEELSS 335 wild Malaysian ...
XP_009388060 265 SGSFYQvpvkqps---------engalndQNeasglidinlavdmtdPDLPPNPCKAIIYHPSVSKLIAATATICDELPS 335 wild Malaysian ...
Q54YY1       436 NKAMLLYICADGFTNEDNhvnqhiqpppsiqqetvpsliddsntnipitttATATnplynKLFTKGLTLNMQKPSqaiNS 515 Dictyostelium d...
Q94BN1       324 ETVMLLYLSASGGPARENv-------------------------------aQPENsvgssRTSKSKLLARASQEQksyKS 372 thale cress
XP_004957070 333 DSILLIYISASGCAEQNM---------------------------------ASQKyasssSSHATAASAFPIDKPnshMS 379 foxtail millet
XP_006838589 324 DGILLIYLSAAGKATSSSsglpl------------------------ssteQNPGdmqahDSVSDGNSISPESSSrdsPT 379 Amborella trich...
XP_006576669 341 DGILLVYLSASGYCGSAQnesgcihf------------------------------------------------------ 366 soybean
EEF38372     336 DGVLLIYLSASGRVGQTIsspva-----------------------gtsitTADNvvrnlYSDTASts---------pFS 383 castor bean
Q5Z480       339 NGMMLIYLSAAGEVGSSGfc-----------------------------pdTNEMvvsslNKFDISNTSTINVNEdngpr 389 Japanese rice
XP_009134734 319 NGVVLIYLSASGKIGQTSlsplgg----------------------rsvtsVEENilrdfESHTIKQDGDPSVQTkpsGE 376 field mustard
XP_009380875 336 DSILLIYISASGKTDCSVa-------------------------------sHKNVngkstNSSKANHAPQASWKRdssPS 384 wild Malaysian ...
XP_009388060 336 DGILLIYISSSGKTDCSVd-------------------------------fQKDVhgnslNFSKAKHTTQASQKRensLS 384 wild Malaysian ...
Q54YY1       516 PTvNnNnNNTTTnvtvptttttatnvtaqttttttttnstststtsnipiykyneapfntkvESLYPMDLLPFCRKPFFL 595 Dictyostelium d...
Q94BN1       373 EPhSnGkLMSAEyyenhlwlg---------------------------------prggssgsNNLYPGDLIPFTRKPLFL 419 thale cress
XP_004957070 380 SDnhlrlgp-----------------------------------------------rgsggpNNLYPEDLIPFTRYPLFL 412 foxtail millet
XP_006838589 380 ESrNlHeENHHNgsrgclrl----------------------------------ssrgneglNNLYPNDIIPFTRRPLFL 425 Amborella trich...
XP_006576669 367 ------------------------------------------------------gprgdrgsNCIYPSDFVPFTRRPLLL 392 soybean
EEF38372     384 SPsNcPnPSSRRckgdclyf----------------------------------gargngglNSVYPTDLVPFTRRPLFI 429 castor bean
Q5Z480       390 lwl---------------------------------------------------gcregegsNCIYPCDLIPFTRRPLFL 418 Japanese rice
XP_009134734 377 RPgQsLrQISEDavehglsf----------------------------------gshgltgpSCIYPSDLVPFTRKPLFI 422 field mustard
XP_009380875 385 QPaTdDkLYSSTnpgsylc-------------------------------------lgaqgsNNLYPDDLVPFTRKPLFL 427 wild Malaysian ...
XP_009388060 385 HPaAdNnPNLSSkighylcl----------------------------------gsqgngasNNLYPEDLVPFTRKPLFL 430 wild Malaysian ...
Q54YY1       596 IVNSQSSDIFNEL--PTFNQPFVSLLSPQSIPKKLV-SNLKC----GNLFTFFLHDPISAFCDISCGN--KIPSKTFNNI 666 Dictyostelium d...
Q94BN1       420 IIDSDTSRAFKVLggAERGEPVAMLLSP-LKPSFENpSTDDTealnGSQFTFFLTAPLQAFCQMLGLSntKPDPELCDEA 498 thale cress
XP_004957070 413 VIDSENSHAFKAIhnAEKGEPAALLLSP-RISSAMSgVESTGh---GSQFTYFLTAPMQAFCQLAGITs-DIDTDTYANA 487 foxtail millet
XP_006838589 426 IVDCDSSHAFKAIsgAEMGETVALLLSPTLPSPCAAdADSTSqpnnGSQFTMFLTAPLQAFCLLVGVPgfNLGMDAFNKV 505 Amborella trich...
XP_006576669 393 VIDNDNSKAFKVIaeAEKGESVAMLLSPSCSPALS----DCShnsnGSLFTMFLTAPLQAFCMLLGLSgtDIDLDTFNKA 468 soybean
EEF38372     430 VIDSDVSEAFKASvgSEKGEPAAILLSPSCSTPLTAv--ESSrhqsGSLFTLFLTTPLQAFCLLIGLSgsDIEMDTYNKA 507 castor bean
Q5Z480       419 VIDSNASYSFKSIhgFEKGETTAMLLSPSCRSSSAGfSGDSVrq-iGSQFTMFLTAPLQAFCHLIGNNgvDIDRDTYNKA 497 Japanese rice
XP_009134734 423 IIDSDNSTAFKNIcgAEKGEPAALLLSPSHTPPLISa--DFSrqpsGSLFTIFLTAPVQAFCLLIGISgsDIETDVFTKA 500 field mustard
XP_009380875 428 IIDSDSSRAFKtIhgAERGEASALLLSH-EKPLSVSeTDLTSs---GSQFTYFLTAPLQAFCQLVGLSp-DVEADIYSNA 502 wild Malaysian ...
XP_009388060 431 VIDSDNSRAFKtIhgAERGEASALLLSH-EKPLFLSdTNVTSg---GSQFTYFLTAPLQAFYQLIGLSs-DIEPDVYSNA 505 wild Malaysian ...
Q54YY1       667 SLLAQNSLEIISKLLFECVdLHPSFSFFLLDDFLRSFIIRFIFCHATFYLHKE-F 720 Dictyostelium discoideum
Q94BN1       499 ESILSASFSEWETILLTSKvLNLVWAQVLPDPFLRRLILRFIFCRSVLTSFSR-T 552 thale cress
XP_004957070 488 ENILFSALEEYEGILCTSVgLNNVWGQVVPDPFLRRLILRFIFCRAVLFyfhped 542 foxtail millet
XP_006838589 506 DEMLSSSFDEWGKMLADSEsLDPVWAHVLTDPFLRRLILRFIFCRGAISLyapts 560 Amborella trichopoda
XP_006576669 469 EMLLSSSLNNWGLALATSDtLNPVWGQILGDPFIRRLLLRFIFCQAVLTLYApvy 523 soybean
EEF38372     508 EALLSSSLNDWGSALATSDtLDPVWAQILGDPFLRRLLVRFLFCRAVLTLfgpsf 562 castor bean
Q5Z480       498 EELLSLSLNEWATTLVASSsLHPVWVEVLGDPLLRRLLLRFIFCRAAHSIFKPtY 552 Japanese rice
XP_009134734 501 ERVLSSSMNEWASTLAASDtLHPVWSQILKDPFLRRLLLRFIFCRAVLALYTP-V 554 field mustard
XP_009380875 503 ESLLSSALAEWEVTLCTSKsLDRVWAQVLTDPFLRRLILRFIFCRTVLSLfcsps 557 wild Malaysian banana
XP_009388060 506 ESLLSSALVEWEVLLCTSNsLDQVWAQILTDPFLRRLILRFIFCRAVLCLLRstt 560 wild Malaysian banana
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