Conserved Protein Domain Family
DUF3535

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pfam12054: DUF3535 
Domain of unknown function (DUF3535)
This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 439 to 459 amino acids in length. This domain is found associated with pfam00271, pfam02985, pfam00176. This domain has two completely conserved residues (P and K) that may be functionally important.
Statistics
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PSSM-Id: 403318
View PSSM: pfam12054
Aligned: 129 rows
Threshold Bit Score: 238.3
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KJE93118      595 SATRSLQKLEALVLSWMTLAITPQGIALNyQDLLLPSIAQLQAQQQRQqqrqsvkmqsfesqanlpppppplaSPPPPGP 674  Capsaspora ow...
4_pfamImport    8 cPHEALSTCIPYIPMWLHLAFYPMSVPIP-PNMLLQQ----NIPV--------------------------------SYF 50  
XP_002070651  678 DLGALLNAACPFVSSWICLAMQPPRLAFD-SAVLIRA----CGGGGG----------------------------VAGDA 724  Drosophila wi...
XP_002053233  687 GLGALLHAACPYVSSWICLAMQPPRLAFD-PAVLIRGSGGASDV---------------------------------AAV 732  Drosophila vi...
XP_001994214  696 DLGALLHAACPFVSSWICLAMQPPRLSFD-PAVLIRA----VAGGGV---------------------------DAATNA 743  Drosophila gr...
Q16JW5        653 ELSALLHASCPYVASWLCLAMQPVRLAFD-PSSLIYA----KPIQPS--------------------------QLRERRR 701  yellow fever ...
ETN62193      714 ELSALLHASCPYVSSWLCLAMQPVRLAFD-PSSLIFA----KPPSHSGa------------------------TNRERRR 764  Anopheles dar...
XP_003241882  562 SLTALLNAACPYIGLWLAMTMQSDKIPYD-TSSIIQHipt---------------------------------------- 600  pea aphid
XP_021207779  614 SLGVILVAACPMLSTWLCLAMQPARLAVD-PALILVP------------------------------------------- 649  domestic silk...
XP_321235     724 ELSALLHASCPYVSSWLCLAMQPVRLAFD-PGSLIYA----KPNQPGGg-----------------------pNRERRPR 775  Anopheles gam...
KJE93118      675 VVKRPrkataarAPAPAEPPSASsASIVASYYGQLLIGNISDrsifdfAeVQRCRLAAFEAIAAVCRHW----------- 743  Capsaspora ow...
4_pfamImport   51 PLSVKiasylqlQSNFLSCNMGTpNEDDKRYIGGVCSNTPPSee-----yVMATREYVASLIGLVCCYGys-------yt 118 
XP_002070651  725 SSTSSrrripklGDDLGGSALAHsNATLKLYLGGSEATPLEVre---aN-FVRARITSSRALGALSHYLvqpapgvvytp 800  Drosophila wi...
XP_002053233  733 SAGSTrrrnlrmGDDLGGVALAHsNAMQKLYLGGSEATPLELre---aN-FMRARITASRALGALSHYLvqpapgvlytp 808  Drosophila vi...
XP_001994214  744 SATNVrrrplriGDDLGGAALAQsNAMQKLYLGGSEATPSEQre---aN-FVRARITASRALGALSHYLvqpapgvlytp 819  Drosophila gr...
Q16JW5        702 QFDSFdsgi---------------psrQKLFLGGSETIPIEMre---kN-VIRARIKTSKMIGLLSRYLvlpapgvvytp 762  yellow fever ...
ETN62193      765 QFDSFesssgsvS------ATHIgGQHQKLFLGGAETVPLELre---kN-VIRARCKASRMIGLLSRYLvlpapgvdytp 834  Anopheles dar...
XP_003241882  601 ---------gpnKVDNVSNMPNEtSIDIKYYIGGSESIPADQre---kN-AIRARHLGAEMLGLLSCYIikpapnicyvn 667  pea aphid
XP_021207779  650 -PLKErrtrtspAEAV----PGEvRAALRWYVGGADTQASAArd---kN-VSRARCLAADILGHLSCYLvqpapgidyta 720  domestic silk...
XP_321235     776 QFDSFdtgggtaACGAGHLSSSSgALHQKLFLGGAETVPLDVre---kN-VVRARCKAARMIGLLSRYLvlpapgvtytp 851  Anopheles gam...
KJE93118      744 PSTA-----LAGIESTLRGLLSSTSFARRVAAGAILAEWATFDTLDVP------------Ss---------VVTTPPATL 797  Capsaspora ow...
4_pfamImport  119 NNDKvtngqAVDMETHLLYLMTSQSAVQRIVASIVVSQWWSEIAATKK-----------------------MHSTPPPTL 175 
XP_002070651  801 QMESp----TDCYTKVLLGHLNAHSAVQRIVCGLIIAFWALEDE---------------------------PVRPGPPNL 849  Drosophila wi...
XP_002053233  809 QMESp----TDCYTKVLLGHLNAHSAVQRIVCGLIIAFWALEDE---------------------------PVRPGPPNL 857  Drosophila vi...
XP_001994214  820 QVESp----TDCYTKVVLGHLNAHSAVQRIVCGLIIAFWALDDE---------------------------PVRPGPPNL 868  Drosophila gr...
Q16JW5        763 EIESp----IDCYTKVLLGYLQSRSALQRLIASLVIAFWCSADD---------------------------TIKPGLISL 811  yellow fever ...
ETN62193      835 ETESp----IDCYTKVLVGYLQSRSALQRLIASLVIAYWCGIDS---------------------------TIQPGPPVL 883  Anopheles dar...
XP_003241882  668 EDESp----VTCYTKLLISNLESNVAMQQKMTSLVISEWCKLQK---------------------------LDSLASKIL 716  pea aphid
XP_021207779  721 EEESp----IDCYVKVMVVYLRSGSALQRLVASLVVSAWARHTRRRGLypppaprpahpdEekdenyetndISKLAPASL 796  domestic silk...
XP_321235     852 ETESp----IDCYTKVLVGYLQSRSALQRLISSLVIAYWCSFDG---------------------------TIQPGPSVL 900  Anopheles gam...
KJE93118      798 RPVLTQMLEeagntTS--YVELTAFIEDMRTECGALLGTFAErgLPKESLSSAGDC---RMYAPL--------------- 857  Capsaspora ow...
4_pfamImport  176 YIAFFKILE-----ESfyFSEISFQFTQVQSDMKAFLATLLS-----------------KRIDIQ--------------- 218 
XP_002070651  850 QEKLHQCVA-----EYfyYDEVAVSLTRLLQETQDFIATLk---QNKIPINDFNNA---KILTLD--------------- 903  Drosophila wi...
XP_002053233  858 QEKLHQCVS-----EYfyYDEVATSLTRLLQEAQDFIATLk---QNKIPINDFNNA---KILTLD--------------- 911  Drosophila vi...
XP_001994214  869 QEKLHQCVS-----EYfyYDEVAMSLTRLLQEAQDFIATLk---QSKIPINDFNNA---KILTLD--------------- 922  Drosophila gr...
Q16JW5        812 QERLKGCLN-----EYvyYDEVGILFTRLLQESRDYLATLk---QHKIQFVEFENL---KVLSLD--------------- 865  yellow fever ...
ETN62193      884 QDRLRACLN-----EYvyYDEVAILFTRLLQECRDYLATLk---QYKVAPPEYAEAgtpKVLTLD--------------- 940  Anopheles dar...
XP_003241882  717 AEKVTDCMN-----RMiyYDEMSFSITKLIQDAHDFLSSLk---HYKLTTPQQLN----QLVTLE--------------- 769  pea aphid
XP_021207779  797 VSTLHTALN-----QAlyYDEVALNCNRILQEARDFLATLk---HYKLPVDGEEFN---NIVRLEqvrpklvirlilnkh 865  domestic silk...
XP_321235     901 QERLRACLT-----EYvyYDEVGILFTRLLQECRDYLATLk---QHRVQLAEYEQL---KVLTLD--------------- 954  Anopheles gam...
KJE93118      858 -------------------------HANELATTffqawtvhldafdttVIQHHQAQISQLAAQVLtpmaaqqlrQLEsql 912  Capsaspora ow...
4_pfamImport  219 -------------------------QWVGLKTCtfr---------faiYYPPHLYLIT----------------DLL--- 245 
XP_002070651  904 -------------------------QIEAVAFS----------------LSENIRHFPLKPKVMD---------TLL--- 930  Drosophila wi...
XP_002053233  912 -------------------------QIEAVATT----------------LSDNLRSYALKPKVLD---------TLL--- 938  Drosophila vi...
XP_001994214  923 -------------------------QIEAVATT----------------LSDNLRSYALKPKVLD---------TLL--- 949  Drosophila gr...
Q16JW5        866 -------------------------QIFQLCTV---------------MSENMKTKYGLKTKIAE---------MLE--- 893  yellow fever ...
ETN62193      941 -------------------------QIYQIATTgp-----------gwSGEEVRVKHCLKPKTAD---------MLE--- 972  Anopheles dar...
XP_003241882  770 -------------------------HIELLTGP---------------ETGILISSQKLKPKIYE---------QLE--- 797  pea aphid
XP_021207779  866 islclkrlnvvtpvrvipsvmkyaaQ-------------------------GMVSRMKPKRAAP----------ALD--- 907  domestic silk...
XP_321235     955 -------------------------QIYQIATAvg-----------gwSADEMRTRYNLKAKVAE---------LLE--- 986  Anopheles gam...
KJE93118      913 rfkqqqiqrlvdqciSKRSRIQSAVAALEFNHERMHIKVLSALAFALIA----------MDPRPDKLNPIVRPLMDAVRK 982  Capsaspora ow...
4_pfamImport  246 ---------------EQCNLLTKLADRALKVQLTLECRVKAFASQAIVSavhssgekdeIWKLPAKLNPLIRPLMEGLKW 310 
XP_002070651  931 ---------------ERRRSLQASYQQTTTEQGSYHVSAQAALAGAICA----------LHCLPEKLNPVVKPLMESIKR 985  Drosophila wi...
XP_002053233  939 ---------------ERRRSLQASYQQTTSEQGAYHVSAQAALAGAICA----------LHCLPDKLNPVVKPLMESIKR 993  Drosophila vi...
XP_001994214  950 ---------------ERRRSLQASYQQTTSEQGAYHVSAQAALAGAICA----------LHCLPDKLNPVVKPLMESIKR 1004 Drosophila gr...
Q16JW5        894 ---------------ERRRGLFNSHASTALEQSNLHISTQASLSGAVVS----------LKCLPEKLNPVVKPLMESIKR 948  yellow fever ...
ETN62193      973 ---------------ERRRCLLSSHSATALEQTTLHISTQSSVSGAVVS----------LRCLPERLNPVVKPLMESIKR 1027 Anopheles dar...
XP_003241882  798 ---------------DRRLSLNQAHKHISSELISLTTSTKASLAGALTM----------LQCLPEKIRPIVKPLMESIKK 852  pea aphid
XP_021207779  908 ---------------ERRRALRAAAAHTHAMHAALAVAVQAAIAGACAN----------LHCLPEKLNPVVRPLMESIKK 962  domestic silk...
XP_321235     987 ---------------ERRRSLLGSHSATALEQTTLHVSTQSSVSGAVVS----------LRCLPDRLNPVVKPLMESIKR 1041 Anopheles gam...
KJE93118      983 EQDEPLHWRAARGLAVLVDRCVDRTPSPNDKIVRAVAGMLAADAAHT-------------------PQLPTe-------- 1035 Capsaspora ow...
4_pfamImport  311 DESPTIRNAVSSTLSLLIGLCRNRQPCPNPKLIKNLCNSMTSHAIPTlklftkgedfilerchvtrPTVa---------- 380 
XP_002070651  986 EQCVPLQQLSAEFLVHLMDQVCDRNPSPNSKILNNLCTLLRSDGDHT-------------------PKLIMpfh------ 1040 Drosophila wi...
XP_002053233  994 EQCVPLQQLSADFLVHLMEQVCDRNPSPNSKILNNLCTLLRSDTDHT-------------------PKLLMpsrtflatr 1054 Drosophila vi...
XP_001994214 1005 EQCLPLQQLSADFLVHLMDQVCDRNPSPNSKILNNLCTLLRSDTDHT-------------------PKLLMpah------ 1059 Drosophila gr...
Q16JW5        949 EECELLQKLSAKYLADLLDQVTVRNPCPNNKIVSNLCTLLKSDADFT-------------------PKLIIpdr------ 1003 yellow fever ...
ETN62193     1028 EECELLQNLSARYLSELLDQVTVRTPCPNNKIVTNLCTLLKSDPEFT-------------------PKVPCpsk------ 1082 Anopheles dar...
XP_003241882  853 ESNEMLQRWSADHLAILMDLCINRSSCPNTTIINNLCSFLCVDPEFT-------------------PKIG---------- 903  pea aphid
XP_021207779  963 EWCEELQANSAKTLATLLAQLADRDPCPNNKVLINLKAFLRCDPEVT-------------------PRVSLerveegged 1023 domestic silk...
XP_321235    1042 EECELLQRLSAKYLSDLLDQVTVRTPCPNSKIVTNLCTLLKSDAEFT-------------------PRVLCpdq------ 1096 Anopheles gam...
KJE93118     1036 ----------GNPkqil-----ddwELGIVTARHqreadlad-----------------------------ataggrgsS 1071 Capsaspora ow...
4_pfamImport  381 -------------------------QCGILTILR---------------------------------------------S 390 
XP_002070651 1041 --------tvMDTmastva-dsncaYYGIVTLTL---------------------------------------------Q 1066 Drosophila wi...
XP_002053233 1055 -sstsvsvhdTCD------------YYGILTLKQqqatggssggggggagtraggtalmptprgpgrppasealaaavaA 1121 Drosophila vi...
XP_001994214 1060 -------tllETRstatvsgndlcdYYGILTLKQ---------------------------------------------Q 1087 Drosophila gr...
Q16JW5       1004 --------emRHFdpant--sdtnpYHGIITLLN---------------------------------------------Q 1028 yellow fever ...
ETN62193     1083 --------llQQFdpnnt--tetnpYHGILTLIK---------------------------------------------Q 1107 Anopheles dar...
XP_003241882  904 -----------TEdr--------ikYELILMHQK---------------------------------------------L 919  pea aphid
XP_021207779 1024 gsgdsagegrHTRplgp----hldkYNGILTLRE---------------------------------------------L 1054 domestic silk...
XP_321235    1097 --------elQHFdpant--ddsnpYHGILTLAK---------------------------------------------Q 1121 Anopheles gam...
KJE93118     1072 TAVSKagdddvaaa-------------------------------------------------------qaiaissgaAT 1096 Capsaspora ow...
4_pfamImport  391 TDKLQ-------------------------------------------------------------------------SE 397 
XP_002070651 1067 QAVKSnstanrgpgsgsttagsgtptaprg------------------------pgrppaseilanaaaaaatieqsvLL 1122 Drosophila wi...
XP_002053233 1122 AASKEis---------------------------------------------------------------------tqQI 1132 Drosophila vi...
XP_001994214 1088 QQATRnnssssgnscganaraggaatstltpa-------------------prgpgrppaseilaaaaaaaasveistQQ 1148 Drosophila gr...
Q16JW5       1029 QKTKEghngtasgsrgpgrp--------------------------------------------ssvtsdiptledalNE 1064 yellow fever ...
ETN62193     1108 QQKSKdqttssgnsssnggagsaggsprgpgrppvv-----------aaanvaldlsssssnatpstphtdegtagstQE 1176 Anopheles dar...
XP_003241882  920 LQNAEkllmkrtgqrgsgr----------------------------------------------ppihcdinveitlSD 953  pea aphid
XP_021207779 1055 QRSADraaprrgrppa----------------------------------------------------aahldldsllDN 1082 domestic silk...
XP_321235    1122 HQRCKesgggggggtssnsgtsgggsssrgpgrpaasstvaaaldlsasssssaaaassssaatattnaaldellggpSE 1201 Anopheles gam...
KJE93118     1097 SSSGADi--------------------------------sAAIARDGAELVLRAASERFQNSIFSMLPRLWGL 1137 Capsaspora owczarzak...
4_pfamImport  398 VNSRKRkrnqidegtiylpnstkvlviiyvlgahflrlvkADISCGGATHCIQTICKMFGKDLFNKVPTLLEI 470 
XP_002070651 1123 AREAEAk--------------------------------qCRIQRLGSACAITKLCSSFGEHIVEKVPIFEQL 1163 Drosophila willistoni
XP_002053233 1133 KEAEARq---------------------------------CRIQRLGAACAIAKLCSSFGDRIVEKVPIFQQL 1172 Drosophila virilis
XP_001994214 1149 AKEAEAr--------------------------------qCRIQRLGSASAIAKLCSAFGERIVEKVPIFQQL 1189 Drosophila grimshawi
Q16JW5       1065 NEETSRk--------------------------------hARTQRLGATHAITTICSYFKQNLPEKLPVLWQM 1105 yellow fever mosquito
ETN62193     1177 NEETSRk--------------------------------hARTQRLGATAAITTICSHFGPLLPRKLPIVWQL 1217 Anopheles darlingi
XP_003241882  954 KDQEQKl--------------------------------nNNIQKRGALYALQTICSYFGEHLQSKLPRLIEI 994  pea aphid
XP_021207779 1083 EDEARKl---------------------------------LRIQRRGATLALVSLTEHFGDSLPQKLPKLWEF 1122 domestic silkworm
XP_321235    1202 SEEMQRk--------------------------------hARTQRLGATAAITTICAQFGAQLPAKLPILWQL 1242 Anopheles gambiae st...
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