4WXX


Conserved Protein Domain Family
DNMT1-RFD

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pfam12047: DNMT1-RFD 
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Cytosine specific DNA methyltransferase replication foci domain
This domain is part of a cytosine specific DNA methyltransferase enzyme. It functions non-catalytically to target the protein towards replication foci. This allows the DNMT1 protein to methylate the correct residues. This domain targets DMAP1 and HDAC2 to the replication foci during the S phase of mitosis. They are thought to have some importance in conversion of critical histone lysine moieties.
Statistics
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PSSM-Id: 403312
View PSSM: pfam12047
Aligned: 17 rows
Threshold Bit Score: 105.889
Threshold Setting Gi: 74864066
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4WXX_A            52 ALPQHKLTCFSVYCKHGHLCPIDtgliEKNIEL----FFSGSA-KPIY-------DDD----PSLEG-GVNGKN----LG 110  human
Q8IKY8           796 NNFLDSINEYHIETSNNKRNIME----KNGEDI----FISDIK-EDKDnnilikqEDF----EKKKKkKILNNKikkhLN 862  Plasmodium...
Q9M0S8           367 DLPCRTLHNWALYNSDSRMISLEvlpmRPCAEIdvtvFGSGVVaEDDGsgf-cldDSE----SSTSTqSNVHDGmnifLS 441  thale cress
jgi:OSTLU_29004   53 TLPMRVLDEYEFRDKFAEGKAVSvhgsRPNRVL----VLGRARkLEGGehg-lpsEVL----AAPLT-PQDKPPhalkLM 122  Ostreococc...
jgi:OSTLU_16926  217 GGIIRLLDDFELVQCETTSASCDtrarRRCIKFhedlFENPDVaATIRisg-rlrEVRsdalAPLGDdDEEDGGrqieVG 295  Ostreococc...
O74560             9 KRKTDLIEQVCVTNKAGELVDLEd--vLEYGPY----SLTGILsSEKD-------EQE----PLFDE--SIVLGysikIS 69   Schizosacc...
Q6Z978             9 EPQLKAVENYYFVDDNDVPVSFDvlpfQFDAAE----GVASFK-KDVYl------------------rGFTDGGlqkvYK 65   Japanese rice
Q7Y1I7           107 GQPCRKIIDFILHDGDGNLQPFEmsevD---DI----FITALI-MPLD-------DDL----EKDRGkGICCSG----FG 163  Japanese rice
P34881            80 DRPTRRLNDFVLFDSDGVPQPLEmleiH---DI----FVSGAI-LPSD-------VCT----DKEKEkGVRCTS----FG 136  thale cress
XP_009117317      86 PRQTRRLTDFILHDEYGVPQPVAmveiG---DI----FVTGVI-LPSG-------ECD----DKEKGkGVKCDG----FG 142  field mustard
4WXX_A           111 P------INEWWITGFD--GGekALIGFSTSFAEYILMDPSPEYAPIFGLMQE-KIYISKIVVEFLQSNS----DSTYED 177  human
Q8IKY8           863 SmnvriiIKEWYIDYVLypNSipYIYVISTNNNRYRLDKPLAQYFHIFTKVRQ-KFEITTRILKTLQVYP----NMSYNR 937  Plasmodium...
Q9M0S8           442 Q------IKEWMIEFGA--EM--IFVTLRTDMAWYRLGKPSKQYAPWFETVMK-TVRVAISIFNMLMRESrv-aKLSYAN 509  thale cress
jgi:OSTLU_29004  123 E------VHDWTIKY----GGdePELWLVTPRAWYKLLNPAPRFEKYVTVTTR-RANFTNAIVRALVKNW----ELSLEE 187  Ostreococc...
jgi:OSTLU_16926  296 N------IVAYQYSFVAtvPEi-RGFYLVTSTATYKLLKPKATYSMLYNRSFQmRYDLARRTARALPRSP----RSSLES 364  Ostreococc...
O74560            70 P------V--WTYNLKDvpEKetMSIWIVTPQRRYGILSPSSEYKAIYEQISE-KNRLFYLIKTKFKDDMisgtLEDYDN 140  Schizosacc...
Q6Z978            66 Q------VVAWKLVLDG--DSp-EIAVLSTEGSWIALLKPRPS----YEETIR-SVLITVEMLHFVRRRPtd-sEKDMWD 130  Japanese rice
Q7Y1I7           164 R------IENWAISGYD--EGa-AVIWVSTETSDYKCVKPASSYRSYFEHFSE-KARVCVEVYKKLARSVggnpQVDLEE 233  Japanese rice
P34881           137 R------VEHWSISGYE--DGs-PVIWISTELADYDCRKPAASYRKVYDYFYE-KARASVAVYKKLSKSSggdpDIGLEE 206  thale cress
XP_009117317     143 R------VENWSISGYD--DGy-PVVWFSTELADYDCGKPATSYKKMYDYFYQ-KAFASVEVYKRVAKSAggdsGVSLDE 212  field mustard
4WXX_A           178 LINKIE 183  human
Q8IKY8           938 LISYLT 943  Plasmodium falciparum 3D7
Q9M0S8           510 VIKRLC 515  thale cress
jgi:OSTLU_29004  188 GLDIIL 193  Ostreococcus lucimarinus CCE9901
jgi:OSTLU_16926  365 IIPELL 370  Ostreococcus lucimarinus CCE9901
O74560           141 YIEVLK 146  Schizosaccharomyces pombe 972h-
Q6Z978           131 HLYGVF 136  Japanese rice
Q7Y1I7           234 LIAGVV 239  Japanese rice
P34881           207 LLAAVV 212  thale cress
XP_009117317     213 LLVAVS 218  field mustard
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