Conserved Protein Domain Family
DUF3522

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pfam12036: DUF3522 
Protein of unknown function (DUF3522)
This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 220 to 787 amino acids in length. This family belongs to the CREST superfamily, which are distant members of the GPCR superfamily.
Statistics
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PSSM-Id: 403304
View PSSM: pfam12036
Aligned: 53 rows
Threshold Bit Score: 103.122
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006827525                  634 HMWQSIALIFSNIAAVFPALWALRQKAFAEWVLFTSSGLSSGLYHACD-VG---SWCALSFHVLQFM----------DFW 699 Amborella trichopoda...
Q4DL71                         11 SWVTFITCCLSHLALLPAIRYLQKRGMHYEVCVSVFSTLVSFLYHSSEs--------LRTP-LF-LStirw---hrlDNI 77  Trypanosoma cruzi...
ESS32612                       43 FHAQLVTTGATNVVLLFGILRSWQVGLPVDAFVGFAAMVTSVAYHTLQtLEgnnPHVFEKARFLGGTegdw---hraDNI 119 Toxoplasma gondii VEG...
Q55D80                         12 KVLQAFIAFSTNLSVIPVVYHCLKRGSAYEGIIGISCALASMMYHVGEv--------FENTWWFKLSgmtsgqwhrlDNV 83  Dictyostelium discoideum AX4...
XP_004367252                    8 RALQALIAFGTNLSCLPLGIMCVKRGTAYEAIVGTACALCSMLYHVGEv--------YEKTWWFKLSgmtsgqwhrlDNI 79  Cavenderia fasciculata...
EFA83638                        8 KMMTAVIAFTTNLSCIPLGVMCVKRGHAYEAVVGVACAISSMMYHIGEi--------YEKTWWFELSglnadkwhrlDNI 79  Heterostelium album PN500...
A0CLA3                         17 MFLMVIITAVSNGVMIPQIIYTYKIKNVHTLFLSGLLFVSSFMYHLSEs--------IGVEPII-LKevdw---hqlDNI 84  Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00497870A  21 AFMMVLITAITNFACMPALCLLYKKNLVFETYVGVFTFVTSFMYHFVEs--------IGAEKLF-MKelew---hqlDNI 88  Tetrahymena thermophila SB210...
A0DY57                         19 MFMMVLITGITNFVVIPAIIIIRKQRMDFQFYISIFTLITSFMYHTLEs--------VDCK-YFIIEeggw---hrlDNV 86  Paramecium tetraurelia...
EEY61896                        7 MTMMLAVTGITNFCMFPAIYSLYRRQFVFEAFIGLFTMATSFMYHVCDs--------IDGP-LW-LTegqw---hrlDNI 73  Phytophthora infestans T30-4...
XP_006827525                  700 LSFVAVVSTFIYMAKI--EEVSKRAIHTSVAILTALIAAEGPTRSENIIIV-VSLGILGLVVGWmielyssrahtlscpq 776 Amborella trichopoda...
Q4DL71                         78 GAISSITIVCLHVCSFe-SEKLVNYLKYFFLFVTIVLQEADPWNILYTAIP-ILCALAMVLVAMllsp------------ 143 Trypanosoma cruzi...
ESS32612                      120 FAITCIISFFAMPLQLv-SPVWVLMTRMVPLCVVAISQCLQPWNFAYTIFPiIFFGVGFLVLLAvsr------------- 185 Toxoplasma gondii VEG...
Q55D80                         84 FTILTFQALCFFLMDIq-SQQSTELLRWTFLVITLYCQERAPWQIEFTIIP-IVSALILLIIRHslrr------------ 149 Dictyostelium discoideum AX4...
XP_004367252                   80 FTILAFQALMFYLTDVs-NPQIMDLLRWTFLVFTLYCQERAPWDITYTILP-IGASFLLLIVSHlyrr------------ 145 Cavenderia fasciculata...
EFA83638                       80 FTILAFQAMMFYLMEYn-HPQIVDLLRWIFLVFTLYCQMINPWNLAFTILP-IVSSLFLLICTHiykk------------ 145 Heterostelium album PN500...
A0CLA3                         85 ASICGLMELFNYLMQN--NRSTRKSIQWINFIFVVIIQESHAWNVWATVIP-ILISLIIFIIKQtfyp------------ 149 Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00497870A  89 GAIMCFITVFIHMANFq-NYNLQMQLNYSAMFIVIILQVADPWNLTFTVAP-IVIYALI-IIALaiyl------------ 153 Tetrahymena thermophila SB210...
A0DY57                         87 GSIVCFQMLFTQLSDLq-NLHLETMLNYFGLFVTFIAQAKSPWDLNYTVGP-ILMQLFICIFLIikr------------- 151 Paramecium tetraurelia...
EEY61896                       74 GSIMSFVMWSIHLMDLgvHPVLERYVQYFFLGMVLVFQEKNPWDERNSVIP-VASSFVLLLMTYamr------------- 139 Phytophthora infestans T30-4...
XP_006827525                  777 fnlnvmerwqelktgvvklidwlrKRFQWRFIFLGFIALLAAG--TCWN-LESVESYWIWHSLWH 838 Amborella tri...
Q4DL71                        144 ---------------------irrRRIAGKNLYVGMASSLLGVicFLRGlDEDRDTYRAWHGLFH 187 Trypanosoma c...
ESS32612                      186 ----------------------vrPRLQRRSCLYSGVTFILAMvfFFFGmDDANDYLRIKHGFWH 228 Toxoplasma go...
Q55D80                        150 ---------------------kipDWIKSKFFLYGFGFFGVAAffFARGlDDNNDYLRINHGIWH 193 Dictyostelium...
XP_004367252                  146 ---------------------rvpEWIKNRYFLYGLGCLVVAGffFARGlDDDTDYLRWNHGVWH 189 Cavenderia fa...
EFA83638                      146 ---------------------kipEWIKNRYFLYGIGSLGIAAffFARGlDDENDYLRINHGIWH 189 Heterostelium...
A0CLA3                        150 ---------------------kkgQIVNKDYLHKGLFYLFIGFiaFYFGlDEYKDYLRLWHGLWH 193 Paramecium te...
WGS:AAGF:cds.TTHERM_00497870A 154 ---------------------ktqPFTNRQMTIKGFSLIFLGAifFSLSqDEHTDYLRIYHGLWH 197 Tetrahymena t...
A0DY57                        152 ---------------------rrlPKLNKQKMKKGLLILLAAIvfFSLSqDEYQDYLRFYHGMWH 195 Paramecium te...
EEY61896                      140 ---------------------rrvPTYDYQQFRRGLLLLVCGIlcFVRGlDDDTDPFRFFHGCWH 183 Phytophthora ...
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