2XXL


Conserved Protein Domain Family
CLIP

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pfam12032: CLIP 
Regulatory CLIP domain of proteinases
CLIP is a regulatory domain which controls the proteinase action of various proteins of the trypsin family, e.g. easter and pap2. The CLIP domain remains linked to the protease domain after cleavage of a conserved residue which retains the protein in zymogen form. It is named CLIP because it can be drawn in the shape of a paper clip. It has many disulphide bonds and highly conserved cysteine residues, and so it folds extensively.
Statistics
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PSSM-Id: 403302
View PSSM: pfam12032
Aligned: 206 rows
Threshold Bit Score: 36.1758
Threshold Setting Gi: 122117753
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2XXL_A               32 CTTPDGDQGQCMPFSSCRTIEER-LTEaqkagQKv-------PADYASYLQKA--LCGe--F--NGVRHFCC 89 
XP_002013941         38 KTQNGRTTGNCISIKECEYFMKI-LSS-----VNl-------TQNDRILLRDN--QCGv--RsrDVPVQVCC 92  Drosophila persi...
EDX12926             31 IPSG-RVTGHCISIRECDFFMKI-LLS-----RNl-------SQSDRNLLRDN--QCGv----rGNDVQVCC 82  Drosophila simulans
WGS:AAQB:GK12812-PA  33 LPDG-RVGGHCIPVRQCDFFMKI-LEA-----GNv-------SDSDRILLREN--QCDi----lNQDIQACC 84  Drosophila willi...
XP_001989686         33 TTDG-RTPGQCTPIRQCGYFMRM-LTA-----PTv-------SQRDRILMREN--QCSpkqPd-DKIVYVCC 87  Drosophila grims...
WGS:AAPP:GF17450-PA  32 QNT--RVTGHCISIRDCDYFMRL-LTS-----GNp-------SQSDRNLLRDN--HCGt----kDKVVQVCC 82  Drosophila anana...
Q175E7               26 CETEDYEEGNCVSIQKCEKFVEMmSQG-----I---------SQGQQRLVDREqeKCA---Dt-GEEGSICC 79  yellow fever mos...
XP_002070129         25 CTTPIGQTGTCLPIRQCQYFTDL---------EDryggslprSVRNELLLM----QCTg--Eq-RRDFYLCC 80  Drosophila willi...
Q7QCV0               25 CYTPNGQIGVCQVFQYCASLIQLyQYN-----RNq-------ETVNFLLASQR--SCGnrn--fnGSPVLCC 80  Anopheles gambia...
XP_001845946         24 CYTPNGTIGVCQSLQNCPSLVRLyQND-----RSr-------QTVNFLVASQR--SCGnrv--faGYPVLCC 79  southern house m...
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