3I4Z,3O24


Conserved Protein Domain Family
Trp_DMAT

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pfam11991: Trp_DMAT 
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Tryptophan dimethylallyltransferase
This family of proteins represents tryptophan dimethylallyltransferase (EC:2.5.1.34), which catalyzes the first step of ergot alkaloid biosynthesis. Ergot alkaloids, which are produced by endophyte fungi, can enhance plant host fitness, but also cause livestock toxicosis to host plants. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 390 to 465 amino acids in length.
Statistics
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PSSM-Id: 403268
View PSSM: pfam11991
Aligned: 106 rows
Threshold Bit Score: 170.934
Threshold Setting Gi: 121797335
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3I4Z_A        31 DQKLWWHSTAPMFAKMLETAN-YTTPCQYQYLITYKECVIpSLG---CYP--Tnsap--rwlSIL--TRYGTP-FELSLN 99  Aspergillus fum...
M2Y2F4        10 HHKFWANHLLPQFRRYIAEIGaYTSKQQDEHVKFFDS-LLpHLGprlPHPhtK---------AVL--TVANMP-LGFSVN 76  Dothistroma sep...
EFQ90212      87 avNVWANYLVPRFHKYLAETGsYTVEQQEAHALCLSAAVV-ALGprhPHPhvK---------SVM--TPNGCP-IELSLN 153 Pyrenophora ter...
XP_003715802  11 DQQYWWQFVEPSLSSMLEYAGqYTPEEQDSHLEWYATQVTpIFG---IQPseEtp-----dpNPF--THDSSP-CHISIN 79  Pyricularia ory...
XP_003347762  56 NHNYWWTACAPSLTSILRHSNsYTPTQQSLHLTWFRNNVIpNLG---PRPssSyr-----lrSPL--NYEGSP-YRPTWN 124 Sordaria macros...
ESA42114      55 NHHYWWTACAPSLTSILRHSHsYTPSQQSLHISWFRNNVIpNLG---PRPssSyr-----lrSPL--NYEGSP-YRATWN 123 Neurospora cras...
Q4WZ67        46 DHRLWWERAASKLATYLRLAK-YSVGSQYQHLLMFYSVYApNLG---PWP--NdkrdnvhwvCGI--CPGGEN-LEISMN 116 Aspergillus fum...
EED52847      25 HERLWWATFGPLLEKLLALCN-YPVSLQYQHLSFIYHHLLpYLG---PYP--Tveng-fawkTAY--SPDGTP-AEVSIN 94  Aspergillus fla...
OBR03216      25 DVDFWSSYLVPRFHAYLSEAGsYTPEQQAAHLSCVRAAAV-ALGpkhPHPhvK---------SAL--TKNGSP-IELSFN 91  Colletotrichum ...
XP_002584693  47 NQSKWWKATAPIFARMLRDAG-YDVDQQYEYLTFMREHVYpHLP---PALgtK---------RVFpnPSSGDPdFELSMN 113 Uncinocarpus re...
3I4Z_A       100 CSN-------------SIVRYTFEPINQHTG-T-DKDPFNTHAI-----WESLQHLLPLe---KSIDLE----WFRHFKH 152 Aspergillus fum...
M2Y2F4        77 LSDar----------kPIARMEIEPLDDTSG-S-AEDLFAANCIpa-cfTTLVKGMt------TRVDTR----WAHQLRQ 133 Dothistroma sep...
EFQ90212     154 LSEdr----------pPTARFYLEPLGSRTG-T-DEDPFGELWT-----PSSFACLAAQv---PSADAR----WYQHLSQ 209 Pyrenophora ter...
XP_003715802  80 WCSkg----------kPTVR---------SGmTrPHDVFNSQAF--------VDELQPAmetsDQPDRA----IFDGLAK 128 Pyricularia ory...
XP_003347762 125 FCSappgssssspkvkGTLRFSFEPIPATGT-S-EEDPTNQEGY-----RRLFPLLAGEchgvGGVETKadltWYNEVKE 197 Sordaria macros...
ESA42114     124 FCSapagsp-ssssvaGTLRFSFDPIPATGS-I-KKDPTNQEEY-----KRLFPLLAREchgkGETKVV----FQSKIVS 191 Neurospora cras...
Q4WZ67       117 YQQga----------kCTVRIAAETITPAAG-T-DKDPFNLTAE-----KKMIEDLKALq---PNLNFT----WFNHFQR 172 Aspergillus fum...
EED52847      95 FDGp-----------kKTVRMDHVPISQWSG-T-PKDPFCQNVA-----LELTKSLAGTl---PDFTWD----WFNHFVQ 149 Aspergillus fla...
OBR03216      92 LSEdr----------lPTARFYIEPLGPETG-T-ENDPFGESWA-----ARGFSCLASQm---TSMDTS----WYEHLGQ 147 Colletotrichum ...
XP_002584693 114 Fqr-----------skSTPRVCFLPIVRGPG--------DDDASyqpdpTRILKTLEPAlr-dAGYSTK----IYDAMKQ 169 Uncinocarpus re...
3I4Z_A       153 DL-T---------------LNSEESAFLahndrlv-ggtirtqNKLALDlK-DGRFAL--KTYIY----PALKAVVTGK- 207 Aspergillus fum...
M2Y2F4       134 AF-----------------TPTSEESAIakprlrp-giervslAYFGITfD-GDNR----AMKYCtshwPKFLGTATAEs 190 Dothistroma sep...
EFQ90212     210 AFrL---------------QGEDEVSKAksqsrp---gvwlptMFMGIDfV-AANRLL--KCSFC----PILKLLAMGAd 264 Pyrenophora ter...
XP_003715802 129 SLfL---------------KDPQEIAKVkavvpph-lhtripnIGIAWDlV-GAKRKL--KLYHN----PQAKKLATSR- 184 Pyricularia ory...
XP_003347762 198 HMyLlnqeravlkerlvpgQLPPEHAAI------------------AIAcS-REKRVL--KPYFF----AGPTSLVTGF- 251 Sordaria macros...
ESA42114     192 RGs----------------QLPPEHAAI------------------AIGcV-GEKRVL--KPYFF----AGPKSMVTGL- 229 Neurospora cras...
Q4WZ67       173 EV-L---------------VPEEvalnndeii---skvpfknqRLHGLDlSeGA-FML--KSYFM----PAIRSAITGV- 225 Aspergillus fum...
EED52847     150 TM-F---------------IPEPATDVVlareppn-frrmamqSVNGCDlLtTG-VRV--KPVFN----ALWKSIETGI- 204 Aspergillus fla...
OBR03216     148 AFrL---------------KGQVEVDTAnsqsrp---gmwlpkVFLGVDfK-GADRML--KCGFC----PLLKLSAMGAk 202 Colletotrichum ...
XP_002584693 170 HM-----------------VASDEEKESlqkkglikgkiyevqSTVALDfGan--gQImaKMYMF----PTLKSFATNI- 225 Uncinocarpus re...
3I4Z_A       208 -----TIHELVFGSVRRLavRE--PRILPPLNMLEEYIRSRGS----------------Ks--------tAS------PR 250 Aspergillus fum...
M2Y2F4       191 nd-atSADAFLFSAIRRL--KPggEALAPSLDAIQHYFQNEr-----------------------------HaklpspIL 238 Dothistroma sep...
EFQ90212     265 wnhlaDHNQFVLDAVRQL--PGfgANAGAALDLLAQYLVEASEsgasvhntsvvnsgleEges-----gpKAktpkpfFN 337 Pyrenophora ter...
XP_003715802 185 -----TGNDIIVSSIRAL--ANdgYNYNEAMDVLERYVTELnpe-------------------------------kleLI 226 Pyricularia ory...
XP_003347762 252 -----SPHQVLFSALRAI--RTrrEELKPAIKLVESYVSSRast--------------------------------mtPS 292 Sordaria macros...
ESA42114     230 -----SPHQVLFSALRAI--RTkaEELKPAIDLVEDYVASRkav--------------------------------mmPN 270 Neurospora cras...
Q4WZ67       226 -----ENTQIMFESIRKLnlKN--ANFISALSTLEDWMVPTNGrfm----------eywDg------------------- 269 Aspergillus fum...
EED52847     205 -----PHDKLLFDSIRNN--TElfGAYLPALQVIEDYCQSDr-----------------------------AkefqtrGC 248 Aspergillus fla...
OBR03216     203 wdrlaDHNKFVLDVVRGL--PGcgANMSAALGMLERYLVQDREhsagaqgqgdgvddgrKdassmcqacaKAnrpkpfFN 280 Colletotrichum ...
XP_002584693 226 -----SCSQIFLDAVRAV---DptGQLFPGLSAIEEFFASSIA----------------Sg--------pGDasstasPW 273 Uncinocarpus re...
3I4Z_A       251 LVSCDLTSP-------A----KSRIKIYLLEQMVS-LEAMEDLWTLGGRRrDA-STLEGLSLVRELW-DLIQLSPglksy 316 Aspergillus fum...
M2Y2F4       239 FVGLDCIDP-------S----RARIKMYGRTHSTA-FSNVRNIMTLGGRA-LTaETTEFLARLRSIWhLLLNDPKakdde 305 Dothistroma sep...
EFQ90212     338 LVSVDCSDL-------Sn--gKGRVKLYARITSTS-FASIRDAVTLGGRL-TDeVTVEGLRHLESIWhLLLNDPAienda 406 Pyrenophora ter...
XP_003715802 227 IIGMDAAEPt-----lP----TTRIKPYGIVAEANsWETVKNIYTLGGQV-LNqERKQGLDILRSIW-DLMRCHRgqrla 295 Pyricularia ory...
XP_003347762 293 CFGIDAVSPfpssdqqGgaaaAARVKLYTLVPSNA-FSVMRDAMTMGGRL-ASpESLRGVALLKWIYhLLRGDRSrvsea 370 Sordaria macros...
ESA42114     271 CIGIDAVSPd----------qGARVKLYTLIPSNA-FCVMRDAITLGGRL-TSpEAMRGVGILRGIYhLLRGDRSpinda 338 Neurospora cras...
Q4WZ67       270 -ISYDAVDA-------C----KARIKIYTGIRMKS-IEHARDVWTLGGRLqGE-DIEKGFDLVARLW-RRLMDEEpstce 334 Aspergillus fum...
EED52847     249 FLSFDATSI-------K----DARLKVYLHGPQTA-YMKVEDAFTLGGRLsNP-NIQTGVKELRKLWyAVLNLPSdfpes 315 Aspergillus fla...
OBR03216     281 LVSVDCADP-------Sn--gKGRVKLYTRTSCNA-FACIRDAVTLGGRL-TDeDTLEGLRRLRSVWhLLLNDPVsqhdd 349 Colletotrichum ...
XP_002584693 274 NVAFDLVEP-------E----HSRIKIYAYETHVD-LKRLEHHWTLGGKL-KEpEHLEGLELMKDLFkRLRIPEGhrkvs 340 Uncinocarpus re...
3I4Z_A       317 papylp--lgvipderlpLM---A-NFTLh-qNDP--VPEPQVYFTTF--GMNDMAVADALTTFFERRGWS-EMARTYET 384 Aspergillus fum...
M2Y2F4       306 dydrp---pldpnslrtgLL---V-SFEVsalVST---PDIKVYVPFWqyHETDVQAINNLEQIFSLLGWD-Wgsgkygd 374 Dothistroma sep...
EFQ90212     407 dyarp----pdskssfpgID---V-NWEV---SNQlpVPHAKVYIPVHifHANDVEVHRNLSQVFRKLGWNdWAEGRYEK 475 Pyrenophora ter...
XP_003715802 296 ddyhm---pkndssstrgVL---TpSFEVk-pGQS--LPDVKVYVSQWqfAKTDREIAECTVEIFKRLGWQ-KEADSYFN 365 Pyricularia ory...
XP_003347762 371 tyhvskpcryetrknsywMG---FtSYEMq-pGRE--DPDVKVYLPLMqfFETEEAVVAALETVWRVLGWGeElgkggyr 444 Sordaria macros...
ESA42114     339 tenmskpcryesksnsywKG---FtSYEMr-pGRE--EPEVKVYVPLMqiFETEQAVIEGLEEVWRGFGWGeLGKGGYGe 412 Neurospora cras...
Q4WZ67       335 --------------mkywMQ---W-VWELr-tDVP--FPVPKLYFSVA--AAEDHYVSDTVVEILDYLGWD-DLVQTHRA 390 Aspergillus fum...
EED52847     316 edlp------atddlyqgWL---V-NYELr-pNNP--VPEPKVYIPVAinNKDQDSIVQGLQEFFDRHE-S-MDVRDYRD 380 Aspergillus fla...
OBR03216     350 eysrt----vaveshrqgID---I-NWEI---SDQlpAPQAKVYVPVSmfHENDLGANRNLSEAFRKLNWLeWAEGRYEK 418 Colletotrichum ...
XP_002584693 341 edy--------piwkdpdSLnpiVvNWELh-pGRP--DPVPKAYFSIR--GLKDMENTEAITEFFASLGWT-HHAETYTP 406 Uncinocarpus re...
3I4Z_A       385 T 385 Aspergillus fumigatus
M2Y2F4       375 l 375 Dothistroma septosporum NZE10
EFQ90212     476 M 476 Pyrenophora teres f. teres 0-1
XP_003715802 366 l 366 Pyricularia oryzae 70-15
XP_003347762 445 e 445 Sordaria macrospora k-hell
ESA42114     413 a 413 Neurospora crassa OR74A
Q4WZ67       391 l 391 Aspergillus fumigatus Af293
EED52847     381 i 381 Aspergillus flavus NRRL3357
OBR03216     419 M 419 Colletotrichum higginsianum IMI 349063
XP_002584693 407 N 407 Uncinocarpus reesii 1704
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