Conserved Protein Domain Family
DUF3484

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pfam11983: DUF3484 
Membrane-attachment and polymerization-promoting switch
This family is the C-terminal region of essential streptococcal FtsA proteins and their homologs. It acts as an intra-molecular switch, triggered by ATP, to promote polymerization of the whole protein and to attach it to the membrane. FtsA is essential for the formation of the septum that divides fully-grown cells into two daughter cells at cell-division. FtsA anchors the constricting FtsZ ring to the membrane.
Statistics
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PSSM-Id: 403262
View PSSM: pfam11983
Aligned: 19 rows
Threshold Bit Score: 36.1943
Threshold Setting Gi: 47504487
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
bgi:05SSU0480 231 VENIAQHAVNGE------TTLRHKPVEipvarpr------isqpiqREivNELNtvDQVEEQVAPtyHDEEEEVRPaaKG 298 Streptococcus ...
Q8E184        349 VDIIAQHAVTGD------EMLRHKPVDfdykektn----tmstmpySE--PLTSsmEDSNLEPIRarENAQEPTEP--KA 414 Streptococcus ...
CAR42814      377 VDVLAQSAVSGE------ELLRRKPVDfsgqesyi-----pnynesnQ--TQVPnySTANQKPLE--YGTQEPATP--KP 439 Streptococcus ...
Q99YV6        377 VDVLAQTAVSGE------ELLRRKPIDfsgqesyl---pdyddsrrPE--STIGyeQQASQTAY----DSQVPSDP--KQ 439 Streptococcus ...
Q8DVE0        377 VDILAQGAVSGD------EKLRRKPIDikpsgvap----ktrsfaqPQ--ESTTleSQLEQLP----PQQKEANEP--KQ 438 Streptococcus ...
Q5M4X9        377 VDIIAQQAVCGE------EYLRRKPIDneaptlsfdrthtpaprvtPQ--PNRIpvENTVEVPQPv---DGENHEQ--KQ 443 Streptococcus ...
Q8DNV8        376 VNLLAQGAIKGE------NDLSHQPISfggmlqkt---aqfvqstpVQpaPAPEvePVAPTEPM----ADFQQASQ--NK 440 Streptococcus ...
WP_014025325  377 IDRLVSQAIASDntyvapVAQYEEPVLpat--------------dtMDyeENNFyqTEAPTRPV-----AQPAAEPeeEK 437 Lactococcus ga...
Q9CEH1        377 IDILVSQAFSGDyaytttEETYVAPVPtitp-----------qattVAdvENDFyvE-PQARPV----VAQKASEPeeEK 440 Lactococcus la...
BAK94086      377 VYQLTKSAVTGE------TTQVEQSSQ-------------------AYtrEAVY--EQPTYEPEEpdYQEADEAE---EK 426 Tetragenococcu...
bgi:05SSU0480 299 -NITDRIRGLFGSMFE 313 Streptococcus suis 05ZYH33
Q8E184        415 -NIGERIRGIFGSMFD 429 Streptococcus agalactiae serogroup V
CAR42814      440 -GITERVRGIFGSMFD 454 Streptococcus uberis 0140J
Q99YV6        440 -KISERVRGIFGSMFD 454 Streptococcus pyogenes serotype M1
Q8DVE0        439 -KVGDRLRGIFGSMFD 453 Streptococcus mutans
Q5M4X9        444 -KLGDRVRGIFGSMFD 458 Streptococcus thermophilus LMG 18311
Q8DNV8        441 pKLADRFRGLIGSMFD 456 Streptococcus pneumoniae R6
WP_014025325  438 eGVVDRMRNMFSNLFD 453 Lactococcus garvieae
Q9CEH1        441 eGLVDRAKNFFGNLFD 456 Lactococcus lactis subsp. lactis
BAK94086      427 eGLGDKVKNFFSNIFE 442 Tetragenococcus halophilus NBRC 12172
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