Conserved Protein Domain Family
GPR_Gpa2_C

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pfam11970: GPR_Gpa2_C 
G protein-coupled glucose receptor regulating Gpa2 C-term
GPR1 is one of six proteins required for glucose-triggered adenylate cyclase activation, and is a G protein-coupled receptor responsible for the activation of adenylate cyclase through Gpa2 - heterotrimeric G protein alpha subunit, part of the glucose-detection pathway. The protein contains seven predicted transmembrane domains, a third cytoplasmic loop and a cytoplasmic tail. This family is the conserved C-terminal domain of the member proteins.
Statistics
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PSSM-Id: 371826
View PSSM: pfam11970
Aligned: 16 rows
Threshold Bit Score: 80.8463
Threshold Setting Gi: 121806441
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q2H1K9   291 WPTSARTSVDLRLLFAYPLVYIILWLFPFVAHVLGYDsSSssssstpLvnPPPPSHWLLVVSILSLCVQGAVDCLLFLLR 370  Chaetomium globosu...
Q6CIQ7   512 KNRRDQIRRQLKSIFVYPMAYLLLWLFPFIVDCSQYS-YE-------I--YNGPIVWLAYIATFMQPLNGVVDVAVFLYR 581  Kluyveromyces lactis
EDO18421 517 VKRRKQIQSNLRSIFIYPCSYIALWIFPIVIDITQYR-YE-------I--SHGPVIWLAYISTIVTPLSSLVDTFVLSYR 586  Vanderwaltozyma po...
Q12361   610 KKRRAQIQKNLRAIFIYPLSYIGIWLFPIIADALQYN-HE-------I--KHGPTMWVTYIDTCVRPLSCLVDVIVYLFK 679  Saccharomyces cere...
Q6FNA4   545 KKRRSQIQKNVRSIFIYPCSYLALWVFPIIADCLQYN-YE-------E--KHGPVMWVTYLDTFTRPLACIVNSMVFFYR 614  [Candida] glabrata
Q7SAB9   459 TRNRERARRQLYALFAYPLVYIIVWIFPFLSHVGYDDk--------iT--PNDP-QWILFVSMVSLGIQGTVDCMLFTLR 527  Neurospora crassa
Q6C142   406 RQRRADIERQMNYIFIYPLAYLLLWTGPFVQQAMQYS-KH-------K--NEYSKFSIMIWAVVSQASNCFIDTVVFILR 475  Yarrowia lipolytica
Q6C970   302 KDRRTAIERQVRTIFVYPVAYVFLWIAPFALQALQFH-YV-------F--HHGTVYWIAAVASFMQPFNLTVDTVAFCIQ 371  Yarrowia lipolytica
Q6BXX0   295 RKRQTQVERQMKTIFIYPVSYIILWIFPLIVHALDFK-YG-------L--SRKPIVWLNSISAFMQPLNCTVDTIVFLIR 364  Debaryomyces hansenii
Q6BW25   304 RARRMQAQWQMRAIFIYPASYLLLWIFTTIVHGMDLR-FG-------L--SVKPHIWMNGIAAFMQPFNCTVDTAVFLIR 373  Debaryomyces hansenii
Q2H1K9   371 E---TPWRY 376  Chaetomium globosum CBS 148.51
Q6CIQ7   582 E---QPWRY 587  Kluyveromyces lactis
EDO18421 587 E---RPWQH 592  Vanderwaltozyma polyspora DSM 70294
Q12361   680 E---KPWNY 685  Saccharomyces cerevisiae S288C
Q6FNA4   615 E---KPWRH 620  [Candida] glabrata
Q7SAB9   528 E---QPWKH 533  Neurospora crassa
Q6C142   476 EsnyRKWRR 484  Yarrowia lipolytica
Q6C970   372 E---KPWRN 377  Yarrowia lipolytica
Q6BXX0   365 E---RPWKI 370  Debaryomyces hansenii
Q6BW25   374 E---KPWKI 379  Debaryomyces hansenii
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