Conserved Protein Domain Family
efThoc1

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pfam11957: efThoc1 
THO complex subunit 1 transcription elongation factor
The THO complex plays a role in coupling transcription elongation to mRNA export. It is composed of subunits THP2, HPR1, THO2 and MFT1. The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm.
Statistics
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PSSM-Id: 403241
View PSSM: pfam11957
Aligned: 46 rows
Threshold Bit Score: 219.601
Threshold Setting Gi: 586739426
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6CB86        73 LAALLDCITYEsq----ttSSdeKPLLESTLTLA-LVEDIFDIHT---VDWCRHFWThYLVSREEQLMNvSRNqassns- 143 Yarrowia lipoly...
XP_011276267  92 IGTLLDFSFYIr----------kIGESLYDMPYE-LIKGVLKEGLv--D-WLLKFWS-YFDLRIEEIKrtkdn------- 149 Wickerhamomyces...
XP_002618753 117 LALILDLAMWM------------TQEHIRVTDFHsLLQTVVDSLSkfsTDTVSVFWT-YMESRESAFLAhVFDr------ 177 Clavispora lusi...
CAR25145      81 fAVIMDLCHHLgr----lrGEdsARKLWITTYFE-LFKQALSFLCl--PRGHLKFWP-YVETRMHWFQS-GYApevkyg- 150 Lachancea therm...
Q6CKD4        84 LSVLLDFCYHLky-----vGEedESKVWAALFFD-LTATCILTLTf--PHELGQFYT-YLRSRLSWYLE-GLSkepvsng 153 Kluyveromyces l...
Q750X0        88 LAAVLD-CVHWmqa---geGAagDAAAWANLYFD-LTKSAMQFLAv--PDGFLAFWP-YFESRLAWYLQ-GQDvvpvrsg 158 Eremothecium go...
XP_003646123  95 LAVILD-CVHAiqcsskhrGDasWAGTWANLYFD-LTKIVMQFLQf--PSSFLSFFP-YFESRLQWYLQ-GQEmeqfsyg 168 Eremothecium cy...
XP_004177699 164 salLLDLCFLSr-------SKrqNPSLWYRSFFQ-LFSTVVDLLIw--PNELLQFWE-YPQSRIEWFKLlGDPssqlplg 232 Tetrapisispora ...
EDO19313      97 CIVVLDFVYHSr-------KNrkIPGNWGSTFFE-IFSHCLNLLSw--PSEMLDFWP-YTESRIEWFKM-GNSlnpveyg 164 Vanderwaltozyma...
XP_003684683 100 LMVLLDYRFLAk-------ESwsDPKTWATSYFN-LFSKILDLLNw--PYQVSEFWP-YVESRITWFKIgNNLinenefg 168 Tetrapisispora ...
Q6CB86       144 -vtrlsgRKAPGTTLIRLANALL------RRVSK-------SRDAVFAGEILIFLSRAFPLSERSGLNQKGEFNVENITV 209 Yarrowia lipoly...
XP_011276267 150 --etlvcLRHPGSSLLITINLRI------NQLYGnh----ePSRDILKAKLLGFTSKIFPAFDKSLINKNFEFNQAHLNT 217 Wickerhamomyces...
XP_002618753 178 ------kITSHRVAMLAICNGLTdqyykrRKTGKldsyekdTFNDNLQSRVRTFLSSLLAFDDSTGLNKYFTIANRANRE 251 Clavispora lusi...
CAR25145     151 -qtnlsaIKAPFSKITFHINKLL------STMREqsk-lstPLHYKLGMKIHWFLSQCLSPMEQANTNRRGNFA-KSLPE 221 Lachancea therm...
Q6CKD4       154 gtnlkmgIRPPAAKLFFSIDTFF------KNIDShsl-fitPNHFELVHKLLWWISQLIPINDHCNINRRAKIT-DEYPE 225 Kluyveromyces l...
Q750X0       159 enrlvsgIRLPLSRLLYHCNELV------RQLEAqsk-lntPRHYMVAHKLQWFMSQLLPASENCNYNKSGELM-AQLPE 230 Eremothecium go...
XP_003646123 169 dnkltsgIKLPLSRLLYYCNELI------RHLEAqsk-lntPLHYVIINKIQWFISQLLPISENCNYNKKGQIL-SQFPE 240 Eremothecium cy...
XP_004177699 233 -tsnlssYKSPLFNKLRHWNELL------EKILLnte-fntPNDYILLFKFKHFLSEILPLNEESNINKFSLISKSQDSG 304 Tetrapisispora ...
EDO19313     165 -stelisYNAPLSQKLRQWNSTL------KTIANnnk-lntEDHYIMKYKFEKFISEILPISDESNFNRSGTLSTNFDTG 236 Vanderwaltozyma...
XP_003684683 169 sntnlisYRLPLSTSLRKWNTKL------NSILNdnnkiynAQSYIMKFKFDKFLSELLPINEESNFNRSGSLYYENVNS 242 Tetrapisispora ...
Q6CB86       210 fegyegakehkevdedededddeddnddddedenenedkdvdmgvdemkekvkektatpatskehtqepsdspyaLFWG- 288 Yarrowia lipoly...
XP_011276267 218 vqyqkvy--------------------------------------------------------------knhafnAFWE- 234 Wickerhamomyces...
XP_002618753 252 phlgsaks------------------------------------------------------------gdeellqEVLS- 270 Clavispora lusi...
CAR25145     222 ---------------------------------------------------------------------------QLWDt 226 Lachancea therm...
Q6CKD4       226 ---------------------------------------------------------------------------TFWAp 230 Kluyveromyces l...
Q750X0       231 ---------------------------------------------------------------------------TLWAq 235 Eremothecium go...
XP_003646123 241 ---------------------------------------------------------------------------TLWSn 245 Eremothecium cy...
XP_004177699 305 ---------------------------------------------------------------------------NVWNe 309 Tetrapisispora ...
EDO19313     237 ---------------------------------------------------------------------------DIWHs 241 Vanderwaltozyma...
XP_003684683 243 rrdvafnnngskl------------------------------------------------------------------- 255 Tetrapisispora ...
Q6CB86       289 -------------------------LQKYFADPTILLNSK---EpEVEMNKLQTCLkATVKTLRSHDGSTeiaqGGGTRW 340 Yarrowia lipoly...
XP_011276267 235 -------------------------LQRAFANPSGILVSDr--TmSEFMSNASLVY-KKIYDAEERANDGplfvVGKKNY 286 Wickerhamomyces...
XP_002618753 271 -------------------------FFRLLRDPYSHLKNP-----RMLSKSVDSMIrLSNYLLEEETKHHrkhpSPDIYA 320 Clavispora lusi...
CAR25145     227 kasefedap-------affndlrkvEHQFVSDPLGWAFTDpsqR-LSLERYLLPVI-DEILLHESYFYAQ----IKRKNL 293 Lachancea therm...
Q6CKD4       231 hlpalpssp-------tilsdwtkiCDDFFLHPLHWLFSHprdK-LTLEPVVHRFV-DEIFVYETELYNL----IKGKNE 297 Kluyveromyces l...
Q750X0       236 rggklrdars-----pslfrdwtyfVEEFVLDPVGVMVSPlreR-QGFEEYTNDII-EFLLEKEQDYYRK----VASAVQ 304 Eremothecium go...
XP_003646123 246 khsrglssrs-----pslfadwnyfLEEFIFDPMNIMLSPvrdR-QGFEEYTNDIV-EFLLEKESEYYKR----LSEVIQ 314 Eremothecium cy...
XP_004177699 310 hsidkskrtls--ardkflddylfiLDSCLTNPLGVVEDFldgRhSDFENTLSSLI-NKTLSYEDEFYSG----IKKHNT 382 Tetrapisispora ...
EDO19313     242 skpsndntirrqtssekflydhsktRSRLFRDPVYFFFKCtetK-STIEQYLTPLL-NVMLEAENEFYNQ----IRVTST 315 Vanderwaltozyma...
XP_003684683 256 ------------apkdkfaqdyhlvKNKIFDNPINLYFNLletK-GSLNNYLMPLL-NDLLRVEDLFYNY----KQKETK 317 Tetrapisispora ...
Q6CB86       341 AKRDSREGGNrggntsa--------------agggsgGSRDFGNSRGHSANNHSSRTLNAKWLTNPDLFTLQLSDTN--- 403 Yarrowia lipoly...
XP_011276267 287 PTNTDKNDYNnsie--------------------nytKAHLTEAKRQELQDFYSNRDYNMSFLVNEKKFNEQIRNDQt-- 344 Wickerhamomyces...
XP_002618753 321 VPAPISE------------------------------NEKQTLAKKYESAVFFPEHYWLAPFEPIQRGAQFDAVKEEdkk 370 Clavispora lusi...
CAR25145     294 RLDRLKHKLHlrasis----------------sgsiaVSRDMTKANKNSTGMSPGNSQNEPFTVRPLMLDQPSWDPElvl 357 Lachancea therm...
Q6CKD4       298 KHAKQEAAVNgkdfyplnfi--------dnvydepddSRNSIFPSKVEFWKEFNLESTKSENIIQLLPLELDLFDLRsfq 369 Kluyveromyces l...
Q750X0       305 GPNLIRQDLHrgliptqas---------tnnfrepqdSRHSICASKAAFWKHYSEVYATLEDVMHPLPLELCMEDEHtln 375 Eremothecium go...
XP_003646123 315 QPNLIRQDIHknfiasqfv---------rnnyiepqdTRNMISETKVEFWKVFVHNDESMNGIMHPLPLELSIFDEQnfl 385 Eremothecium cy...
XP_004177699 383 KILNANTTLNenypieneqntnsdnnanitkipnymkQNATMTQNRNDFWKNLDDSLSFYANTFQPTWLDLSINNVEnfy 462 Tetrapisispora ...
EDO19313     316 RISAANNALNkgypfnydsl--------kikessfvkSSVAIQEKLAKHWDGFYKCYNDRKQLPSITFLDLSSKNADglf 387 Vanderwaltozyma...
XP_003684683 318 KLFLMNFQSNknypsnfdikn-----sngmktpsylkLQTHGTKIRLKEWKNFMNQFSSSKLMISPSFLELSKLDTNfly 392 Tetrapisispora ...
Q6CB86       404 ----------FRRAIWTQILIFSEFMLSLTEKNKAKIPatATNRSVQYQ--------------YtlsaaDEIYFESVVAH 459 Yarrowia lipoly...
XP_011276267 345 ----------FRKTFLIQLIIVLGFFSNLDDA-------------------------------RvlddaRASFNLRKAAR 383 Wickerhamomyces...
XP_002618753 371 vaiaqfdsskFRQLVLLQIYMVSCFFLELQNSKKRATLknINAPASTKHi------------------qEASTPESLIKS 432 Clavispora lusi...
CAR25145     358 srlqdpfndfFRKQVVIQLVIASNLVERVLEDDSIKAFysSqhyq--------------nldpSvg--gdSEKTLKDLGY 421 Lachancea therm...
Q6CKD4       370 drieayeydyFRKLVISQVYLTFYLLKEIISNDTLVHYygKIFNQSSLShsskwrveygdnvlN-----KNDSAINFLTK 444 Kluyveromyces l...
Q750X0       376 hqletvevdtFRKLVLLQITITCNIVDQILRDKAIYRTyvTRYKNVHSGrai---------------pnDPPTLFKFFST 440 Eremothecium go...
XP_003646123 386 nqletveldfFRKNMLMQIAISFNMVDTILRDKATLKAytARYKNAHYDrif---------------ppDPPTLFKFFYS 450 Eremothecium cy...
XP_004177699 463 lqftdynndfFRKQFILQVTFALTFIKEFLNSNDIQTFykNIFKKEDLTeresil---selneK-----NKDQIISFCNK 534 Tetrapisispora ...
EDO19313     388 qqysrtdndyHRKQFILQFSSFVSLLNILASSEEASNFykTCHAKDNPTrkdyd----dsltpT------QKSLIAYFQQ 457 Vanderwaltozyma...
XP_003684683 393 yqmikknndfFRKQFILQLCFVIGIFLQISESPEVRSFyvNSLQKDNPSkris------nmneEs---nIQKSLVAFFKN 463 Tetrapisispora ...
Q6CB86       460 FES-SGKNKPPYKpghspdfNAVLSRIIPH-----------VFKFDEKWVEWK-----LE-NCPAYEKP---VMNNIDeV 518 Yarrowia lipoly...
XP_011276267 384 VATpYLYDIRNLR-------REA-NNIFNAldkreffgnqmLISSEFTFFQAK-----LK-QFRNVETIyneVQLDDElY 449 Wickerhamomyces...
XP_002618753 433 FLQ--LKRDIPRScr---awDTQLSFLFQQ-----------LSQSEENWWAWLlygkkSD-GTSLLSEN---VLTDDEiS 492 Clavispora lusi...
CAR25145     422 FIKdRVRRFYEQR-------DTVFQGLLDH-----------MLINEDALLELK-----TKrGFKIFSSF---TFPEKGlS 475 Lachancea therm...
Q6CKD4       445 KLN-RISSFYEIR-------DRQFYELLNH-----------LAQNELDALNQK-----VG-DFSNLKDI---HWSSDL-I 495 Kluyveromyces l...
Q750X0       441 AVG-RIRDFYRVK-------DPQFFDMLNE-----------LLHADESFLFAK-----AA-NMAPFKEI---AWNTESlG 492 Eremothecium go...
XP_003646123 451 TAN-KIKEFYKQK-------DYEFYEILIE-----------LLHSDESFLAAK-----SK-NMAPFKEI---KWNCKPiD 502 Eremothecium cy...
XP_004177699 535 IIElRVPQFYCSR-------DRKFYDILNS-----------LLYSDNELLIQK-----MD-GFKKFQKF---KISEIE-N 586 Tetrapisispora ...
EDO19313     458 LFEtRIVSFYKNR-------DPTFLKIILA-----------LIKSDEKLLSSK-----ID-GFKEFSNL---KTSGEE-I 509 Vanderwaltozyma...
XP_003684683 464 LYEtRIKAFYEEK-------DPKFMNILNL-----------LINSDSQYLKAK-----ID-GFKEFQLD---ETNAFQ-F 515 Tetrapisispora ...
Q6CB86       519 EGVEELITKLGhvrpRWRYEMGTEALTKIMAVECGLS---LLEkKPdLPSIGTPQvyidklseldKVKKLDWDFLDEAEq 595 Yarrowia lipoly...
XP_011276267 450 DKLKQEGAFKK----RFWALYGNAQISSHWKIPTGLS---LLEkDTsKNT----------------REEKDKNLEILREt 506 Wickerhamomyces...
XP_002618753 493 TTREKFETVVPyktkRYFNTHVTPQLSRRMKVKTGLG---LLRtKAeVDYESEIE----------KIDKELLSADLESKp 559 Clavispora lusi...
CAR25145     476 EAPSPKYSFKG----FGWSKFGNKKLDAAWKTETGLQ---NIK-MDaESPQAVFE----------ELRTEYKTEDTSVSd 537 Lachancea therm...
Q6CKD4       496 TVPTANNAFKK----FGWIKLGNKKLDGLWKVQSGLDlarKYSeNNrQDPSELYD----------TIISEYKDKTEKTDg 561 Kluyveromyces l...
Q750X0       493 HAPEPACSFKK----FGFITMGNKRINDVWKIESGLKrtkDLAkAReIDPTGVYS----------ALQAVAATAGAATDa 558 Eremothecium go...
XP_003646123 503 GKPSFDYEFKK----FGFIKLGNKKVNDIWKIESGLDrarILSkANeINPSAVYN----------KLQEEFQNSNVKNSq 568 Eremothecium cy...
XP_004177699 587 VPPTFNNNFAK----FGFILLGNKNINNVWKLNFNIH---DIKmDEqNNPSIVFN----------NLQTVWEQNKKSTEp 649 Tetrapisispora ...
EDO19313     510 KVPSIDENFKK----FGFVKLGNKNINNVWKIDSGLD---LIKtKS-VDARENYG----------ILKRKWEEDPNNEEg 571 Vanderwaltozyma...
XP_003684683 516 HSIVVDRSFKK----FGFIKLGNKDINTVWKIETGID---VIKeNY-VDPTKIYN----------ELENKYESGGFEEEt 577 Tetrapisispora ...
Q6CB86       596 akcledisaADWLGWRAARVGGLWS-----KLGEATVLNEVVNGAKDQKDTRESVDIEEGGAVEVEE 657 Yarrowia lipolytica
XP_011276267 507 ikstedqdlKDVVSWKALRLSRQNHlfdfkHVNGSIGLEGLYDHSLKEADDIKRKEETEKLEKEEEE 573 Wickerhamomyces ciferrii
XP_002618753 560 el----iekRTVLIWKKLKYNRNKQwlsfgEVSA--ELVENNDLTRSLEKEKLKEEQQRKSDVKKED 620 Clavispora lusitaniae ATCC 4...
CAR25145     538 ta-----hhDTVKQWRQMRVLRPQYvfqlgNVDERTGMEGLFNENVVTESQNHKKELRMEREEESRK 599 Lachancea thermotolerans CBS...
Q6CKD4       562 det--ttdnVIVKQWQNLRSLRPKYlfefnKVSEKTTLAGFANEELIRNDIESKKRRLAERIESKKK 626 Kluyveromyces lactis
Q750X0       559 d-------sRIVKQWQDLRALRFEYlfelaKVDETTGINGLFDPTLIAASREDKDKRISALHEAYIK 618 Eremothecium gossypii
XP_003646123 569 nsg---tdgSILKQWQLLRSLRSQYlfefnTIDETTGIAGLFDPNLAKNSKENKAKNTNSYFEKELN 632 Eremothecium cymbalariae DBV...
XP_004177699 650 qnss-yddnNIVKQWQSLRSLRSEYlfnfkGLDEETGINGLFDSELVQASQNKKDDLIEKLKNKANE 715 Tetrapisispora blattae CBS 6284
EDO19313     572 n-------dKIVTQWKNLRILRSQYlfdfnKVDEDTGISGLFDDSRVAASTERKDEERQNLVKKLKS 631 Vanderwaltozyma polyspora DS...
XP_003684683 578 kt----endTIVKEWQTLRLLRSKYvfkfdSFDEDKGIKSLFDKSKKVESNKKIEDIIDEMNTEIKE 640 Tetrapisispora phaffii CBS 4417
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