Conserved Protein Domain Family
Spt5_N

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pfam11942: Spt5_N 
Spt5 transcription elongation factor, acidic N-terminal
This is the very acidic N-terminal region of the early transcription elongation factor Spt5. The Spt5-Spt4 complex regulates early transcription elongation by RNA polymerase II and has an imputed role in pre-mRNA processing via its physical association with mRNA capping enzymes. The actual function of this N-terminal domain is not known although it is dispensable for binding to Spt4.
Statistics
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PSSM-Id: 403226
View PSSM: pfam11942
Aligned: 88 rows
Threshold Bit Score: 33.392
Threshold Setting Gi: 374095446
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGG10140       66 YIDDLADVDDEDeEE-EEEEDGLGGPEDDFIDRNEIPEAGQSsrRnllrdiggdddfeMDAGHRGLDMSRQARED--ADL 142  Melampsora la...
EEH53863      181 FIDDMADVEDDD----EEEDDEGDDIDEDLGEEEREAVMREAeqR-------------VHARYENLERMERM-----ENE 238  Micromonas pu...
XP_002993560   77 FIDDAAQVASDE-EE-EEEEEEEGFIEDT--------IPEEEssR-------------RSRIPQRPALLDTG-----EDL 128  Selaginella m...
XP_006655898  107 FFDEEAQVDEDE-EEeDDGEGEDDFINDA-----GADLPDEDvvR-------------GSR-HRSMPMRDEE-----EDI 161  malo sina
CBI19960       83 FLDLEAAVDSDE-EE-EEEDGEDDFIVDA-----GAELPDEDdgQ-------------RMRRRPLLPQEDEQ-----EDF 137  wine grape
EEF36249       90 FFDLEAEVDSDE-EEeEDDDAEDDFIVDN-----GADLPDEDdgR-------------RVHRRPLLPREDDQ-----EDM 145  castor bean
XP_002305464   97 FFDDIAQVASDD-EE-DEDDGEDDFIVDD----HGADLPDEGsgR-------------RMHRRPLLPAEEDQ-----EDV 152  black cottonwood
XP_002999304   60 FIEEEADVDEDEe---EEEDDDDDFYRSE----RQMAEEVES-----------------GHSYRYEPQDR-TQFDesESA 114  Phytophthora ...
XP_024583814   57 vnkfieeeadvdedeeeeedddddFYRSE----RQMAEEVEA----------------GH-AYRYEPQDR-AQFDesESA 114  Plasmopara ha...
POM64885       60 FIEEEADVDEDEe---EEEDDDDDFYRSE----RQMAEEVEA-----------------GHSYRYEPQDR-TEFDesESA 114  Phytophthora ...
EGG10140      143 G--QIAADFRERYGRqSRAAARDMGEH-------IPKNMLMP 175  Melampsora larici-populina 98AG31
EEH53863      239 E--ELEAALKERYAAhRAAADYGDVGIgt----eVDQQALHP 274  Micromonas pusilla CCMP1545
XP_002993560  129 EdiEIEKMLQQRYKTtSYDTYDDSEATv------VEQQALLP 164  Selaginella moellendorffii
XP_006655898  162 E--EIERRVRERYARsTHIEYGEEAAE-------VEQQALLP 194  malo sina
CBI19960      138 E--ALERKIQERYGKsSHAEYDEETTE-------VEQQALLP 170  wine grape
EEF36249      146 E--ALERRIQARYARsSHTEYDEETTE-------VEQQALLP 178  castor bean
XP_002305464  153 E--ALERSIQARYAKsMHSEYDEETTE-------VEQQALLP 185  black cottonwood
XP_002999304  115 E--AIVNRIKKRHQQ-SRKQYDGDEEGgdviqseVAQQSLLP 153  Phytophthora infestans T30-4
XP_024583814  115 E--AIVNRIKKRHQQ-SRKQYDGDEEGgdviqseVAQQSLLP 153  Plasmopara halstedii
POM64885      115 E--AIVNRIKKRHQQ-SRKQYDGDEEGg-------------- 139  Phytophthora palmivora var. palmivora
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