Conserved Protein Domain Family
DUF3456

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pfam11938: DUF3456 
TLR4 regulator and MIR-interacting MSAP
This family of proteins, found from plants to humans, is PRAT4 (A and B), a Protein Associated with Toll-like receptor 4. The Toll family of receptors - TLRs - plays an essential role in innate recognition of microbial products, the first line of defense against bacterial infection. PRAT4A influences the subcellular distribution and the strength of TLR responses and alters the relative activity of each TLR. PRAT4B regulates TLR4 trafficking to the cell surface and the extent of its expression there. TLR4 recognizes lipopolysaccharide (LPS), one of the most immuno-stimulatory glycolipids constituting the outer membrane of the Gram-negative bacteria. This family has also been described as a SAP-like MIR-interacting protein family.
Statistics
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PSSM-Id: 403222
View PSSM: pfam11938
Aligned: 73 rows
Threshold Bit Score: 71.5627
Threshold Setting Gi: 75032011
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4Q576        60 DCSACITVartlFERLNQTLAENPS---TYLISHRLgk---knQLRrRQYRNSELLVTEVMENVCtSYKNDaRLLRLHPK 133 Leishmania major
XP_002602980  28 YCGACHVL----VDEIDYAIRQIDPrktIQVGSFRVdpkgnqkTWE-IPYARSEVYLTELVETVC-EKMNQ-YAQSTDPD 100 Florida lancelet
XP_793411     34 YCGACQAL----ISEVEYAITQEDPhqtITVGSFRIdpkgeqkQKK-IPYAGSELHLTEVMETVC-DKMTD-YAEKTDPE 106 purple sea urchin
8_pfamImport   1 HCGGCRA-------ELDWETAQVDPkktIRTGSFQInpdghqsVVE-VTYARTEAHLTEQLLEVC-DQMKE-HGDQTDPP 70 
Q28FU2        31 HCGACRAL----VDELEWEISQVDPkktIQKGSFRInpdgtqsVIE-VPYARSEAHLMEVLEQIC-EKMTE-YGEKIDPS 103 tropical clawed...
Q95QN1        25 ECGACSLL----VTHFELKIAAVDPkkkIEVGSFRVsptgdqkGLKeIGYARSESHLTEIIEHAC-DDAKH-YKLVVNTI 98  Caenorhabditis ...
XP_005061446  44 HCGACRAL----VDELEWEIAQVDPrktIQMGSFRInpdgsqsVVA-VPYARSEAHLTELLERVC-EKMKE-YGEKVDPA 116 Collared flycat...
CAF96536      31 KCGACRAL----VDEMEWAISQVDPkkmIQTGSFRInpdgsqsIRE-VPLARSEGHLLELMEGVC-ERMED-YGELADAS 103 spotted green p...
9_pfamImport   1 YCGTCKAI----MSEVEHSISQIDPnkkIDVGSFRVdpngktrTIQ-KPYARSEAHLTGLLETVC-NEVSEnYVESKDAE 74 
PIC42169      27 ECGACSLL----VTHFELKIAGVDPkkkIEVGSFRVsptgeqkGLKeIGYARSESHLTEIIEHVC-DEAKH-YKLVVNTI 100 Caenorhabditis ...
Q4Q576       134 SKVRLYHQQVFgdtrlgvrhalredevypadaDPAAWAEklDGQLYpiarlysrrdadalqglQSLSATPTMCALLVEEF 213 Leishmania major
XP_002602980 101 TQKKSYVRTSSrng---------------etlSLSNISM--NQDIS--------------------KALRFACESIIEDF 143 Florida lancelet
XP_793411    107 TNEKTYVRYQArng---------------edmELINVSI--NLTTG--------------------KVLKVACENIIEDY 149 purple sea urchin
8_pfamImport  71 THRKNYDCVGGrnge-------------snelDLQAIWT--DSDIR--------------------GTPKFACENIVEEQ 115
Q28FU2       104 TDRKIYVRVVSrdg---------------kkmDASGTNI--DIEVT--------------------SNLKFTCERIVEEY 146 tropical clawed...
Q95QN1        99 TGKSVYVHndathl-------------------------------------------kgdespKMRYNLQNACNDFIDSH 135 Caenorhabditis ...
XP_005061446 117 THRKSYVRVIShdg---------------tkmDLSGLKF--DGDVT--------------------SSLKFACESIAEEY 159 Collared flycat...
CAF96536     104 THRKSYIRVRSrgg---------------eamDLSQATL--DSRVT--------------------ASLKFACETIVEQH 146 spotted green p...
9_pfamImport  75 SGKMRLKRMVThdgkm------------ssdvDFQSLME--NSKNSdap------------pdAKTKKVKFACESIIEDY 128
PIC42169     101 TGKSVYVHkdatyl-------------------------------------------kgdessKMRSRLQNACNDFIDSH 137 Caenorhabditis ...
Q4Q576       214 EDEIESLVKS--VRsLEETEHSLCG 236 Leishmania major
XP_002602980 144 EDDMVKLFSKegPK-LHELQNSLCM 167 Florida lancelet
XP_793411    150 EDEVLRLYRE---K-STDIETSLCS 170 purple sea urchin
8_pfamImport 116 ENELTEFFSQ---E-ANSMNNKFCR 136
Q28FU2       147 EDELIEFFSH---E-RENVKDKLCS 167 tropical clawed frog
Q95QN1       136 EDELLGFLKTa----HQDPVKQFCQ 156 Caenorhabditis elegans
XP_005061446 160 EDELIEFLSH---E-AENVKDRLCS 180 Collared flycatcher
CAF96536     147 EDEIIEFFAH---E-TDNVKDKLCS 167 spotted green pufferfish
9_pfamImport 129 EDEILHHFKN---E-HNNADLKICA 149
PIC42169     138 EDELLTFLKTa----HEEPVKQFCH 158 Caenorhabditis nigoni
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