3K1L


Conserved Protein Domain Family
FANCL_C

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pfam11793: FANCL_C 
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FANCL C-terminal domain
This domain is found at the C-terminus of the Fancl protein in humans which is the putative E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits of the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2.
Statistics
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PSSM-Id: 403100
View PSSM: pfam11793
Aligned: 9 rows
Threshold Bit Score: 111.366
Threshold Setting Gi: 222424329
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3K1L_A       307 EELRCNICFAYRLd--------GGEVPLVSCDNAKCVLKCHAVCLEEWFKTLMDGKTFLEVSFGQCPFCKAKLSTSFA 376 fruit fly
Q9CR14       303 FSMDCGICYARHL---------NGAIPDQVCNNPQCGQPFHEICLYEWLRGLSTSRQSFNVFFGDCPYCSKPITLKMS 371 house mouse
Q3MUH5       301 FTKDCGICYAYRL---------NGTTPDQVCNEPRCGQPFHQACLYEWLQGLPSSRQSFNVIFGECPYCNKPLTVKSS 369 chicken
XP_001315697 268 TEIECPICFCERF---------GGELPEIVCENPKCAKHYHRSCLVDWLRENRKMEQSFHCIYGTCPNCGAKIQVDDS 336 Trichomonas vagin...
BAH20121     221 QQVECGICYAQFLptdeelgarSGTRTDYTCENISCNKSFHSLCLTDWLRSITTTRQSFDVLFGNCPYCSDPVAVKTS 298 thale cress
Q7PSZ3       146 GEDSCGICMNYQDg--------YDRVPVISCDNEQCNLIFHIHCLKEWFATQRESKKIFTISIGNCPYCTHKISSSFD 215 Anopheles gambiae...
Q17FW9       295 DAIQCGICMSYRDd--------QNKIPIISCDNEKCSLIFHIGCLKEWFMSLKDSRTFFAISVGTCPYCKQKVSSSFD 364 yellow fever mosq...
EDO38136     301 FSMECGICYAYRL---------NDTIPDKACDDPRCGQPFHRDCLYEWLRSLPSSRQSFNMVFGECPYCSKPITVKMT 369 starlet sea anemone
XP_017949337 267 fSMDCGICYAYRL---------DSAIPDQVCDDPRCGQPFHQACLYEWLRGLPSSRQSFNIIYGECPYCNKPITLKMS 335 tropical clawed frog
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