Conserved Protein Domain Family
SPT_ssu-like

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pfam11779: SPT_ssu-like 
Small subunit of serine palmitoyltransferase-like
Serine palmitoyltransferase (SPT) catalyzes the first committed step in sphingolipid biosynthesis. In mammals, two small subunits of serine palmitoyltransferase, ssSPTa and ssSPTb, substantially enhance the activity of SPT, conferring full enzyme activity upon it. The 2 ssSPT isoforms share a conserved hydrophobic central domain, which is predicted to reside in the membrane.
Statistics
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PSSM-Id: 403091
View PSSM: pfam11779
Aligned: 62 rows
Threshold Bit Score: 44.8708
Threshold Setting Gi: 748523144
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WGS:AAAA:OsI_25837   4 MNWVSRKIHLYNVTMGLYMLDcCFPLTGV------------DIM----------VLILLWFICFNGSRFasdvFESPSFA 61  long-grai...
Q0D6S2               4 MNWVSRKIHLYNVTMGLYMLD-WWERCLF------------SILfhltpycllqIIIIAIFLLILSSGF----WLDSirf 66  Japanese ...
XP_015645222         4 MNWVSRKIHLYNVTMGLYMLD-WWERCLF------------NMM----------VLILLWFVCFNGSRFasdvFDSHLKA 60  Japanese ...
XP_019928326         7 KNFISYWYLQYLLATSVYMLE-PIERRIF------------NCV----------LIIVLAMFMYTSYVF----LPDHARM 59  Pacific o...
XP_002411920         8 yKKLKWYYFMYDLHTSLYMLE-SWEKRVF------------NIG----------LVAVFAMSSYTTYVF----LPRYTRN 60  black-leg...
ELU43916           231 KRFLWRRQIWFESTFALSMLE-PWEKILIsesscsaadaeeLAL----------IF-VWSLFITGAVRY----LPNHIST 294 Rhizocton...
1_pfamImport         1 -NKIKRLKLALEATTAMNMLE-PFEYYAM------------YTV----------ILLLFFLALYGCYWF----LPSHLRH 52 
SAM75609            82 QRKLFRAYWNVEATFVLSMLE-AWEVFLV------------IMV----------FLTLTLLLWYSAYHY----FPRHARE 134 Ustilago ...
EST10136            80 ERNLFRTYWNIEGTFVLSMLE-AWEVFLV------------ICV----------FITLTLLLCYTVVHY----LPRHASE 132 Kalmanozy...
KIS70990            79 ERTLFRAYWNIEGTFVLSMLE-VWEVFLV------------IVV----------FCLLTLLLWYSLIHY----FPRHAQQ 131 Ustilago ...
WGS:AAAA:OsI_25837  62 I 62  long-grained rice
Q0D6S2              67 g 67  Japanese rice
XP_015645222        61 R 61  Japanese rice
XP_019928326        60 I 60  Pacific oyster
XP_002411920        61 V 61  black-legged tick
ELU43916           295 M 295 Rhizoctonia solani AG-1 IA
1_pfamImport        53 L 53 
SAM75609           135 V 135 Ustilago bromivora
EST10136           133 V 133 Kalmanozyma brasiliensis GHG001
KIS70990           132 V 132 Ustilago maydis 521
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