Conserved Protein Domain Family
Hyphal_reg_CWP

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pfam11765: Hyphal_reg_CWP 
Hyphally regulated cell wall protein N-terminal
The proteins in this family are all fungal and largely annotated as being hyphally regulated cell wall proteins, and several are listed as the enzyme EC:3.2.1.18. This enzyme is acetylneuraminyl hydrolase or exo-alpha-sialidase, that hydrolyzes glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Statistics
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PSSM-Id: 403079
View PSSM: pfam11765
Aligned: 71 rows
Threshold Bit Score: 155.85
Threshold Setting Gi: 410730273
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAR65602        9 TLIALAGSVSgltISEPTVQNGAINLGlrigDDLDINSDAYLTIINAILS---ADVGVGSINNNGGFYFKYDG-GIAAVS 84   Debaryomyces ...
EEQ40716       12 CLASTIFALI---VSENLDVVGNANHF----GDLYIDPGVYLAFDNRNGYirnTFDG--VVTVNGQLFVIDTG-NNEGMS 81   Clavispora lu...
EEQ41473       13 vVVRSVLGLIt--ISANTDNLGAANYN----DDLLIKSGVYLSYNNQNGQilnTFHG--SVTNDGQLCIGDNG-HNTGMS 83   Clavispora lu...
XP_003678549   16 lAVPLVKGLE---ISTNTVLDGNVPAN----EAVTINSGAYLALIHGITQ---SISGDLKV--DGSLFIGDTNsADPGMK 83   Naumovozyma c...
CCD27441       13 FLLSSSLGYE---VSIDTILDGSVPAG----EAVTVDSGSYLGLIHGSTQ---TFSSDLTV--NGGLYITDTNtADAGMT 80   Naumovozyma d...
XP_003671892   12 LLATSTFAYE---VSTNTVLDGSVPTG----EPVVVDSDAYLALIHGSTQ---TFSNDLTV--NGGLYISDSNtADAGMT 79   Naumovozyma d...
CCK72036       41 CIAGFAASIS---VSTDTILAGSVAGT----EDVDVNSGAYLAIIHGATQ---NFGGNVNV--DGALYIGNADsSDGKLN 108  Kazachstania ...
Q6FUW7         16 IFIDQARAAT---IKENTYYSGELPS-----EGFTVNSNQFLALVNTKTV---NFAGPLTINKDASVFIGNENaANGAIS 84   [Candida] gla...
Q6FQC7         14 ALIQLASSAT---IDKNTYLDNLPS------EDITVNSNAFLALIHANTY---TFNGG--INNNGYLFMGNVNsGQSGLK 79   [Candida] gla...
XP_003671316   17 QIITSIAALE---ISENTVIDNLATVT----DDLTIDRGSYLLVTYDPSV---SINSN-NIVNNGNLCIGTAS-TTDSIS 84   Naumovozyma d...
CAR65602       85 AA-VATGDIGNEGTIVF-SSETDSLATVLGLtTAlGKFKNgaDGKVYFDSQDg-VASVYELVGv--NGWENDGLIYMRQS 159  Debaryomyces ...
EEQ40716       82 VT--FGSGFTNNGDVVL-NAASETSACDFRF-TG-PAFVN--SGHIYMGGIGntGGSTMNIWPslvTVPQNYGTITYAQS 154  Clavispora lu...
EEQ41473       84 VY--FYKGITNNGQVVL-NANNETSAPSFYF-NG-PTFVN--DGEILMSGIGntGGSTMDIWPslgTVPENRGTILYAQS 156  Clavispora lu...
XP_003678549   84 VT---LGNIDNSGTIVI-DNRNATTGSTLNI-GG-STFEN--DGYMYVAGSStgIVNSWNIQPv--DSIVNKGTMQFSQD 153  Naumovozyma c...
CCD27441       81 LT--TDGNLVNTGIIVV-DNRNASSGMTANI-GG-STFEN--DGQIFFAGSSqgSPNDFTINPs--DSIINRGTIQFSQD 151  Naumovozyma d...
XP_003671892   80 LT--TNGNLENTGIIVV-DNRNATTGMEATI-GG-STFRN--DGQMFFAGSYkgTSNAFNINPs--TSLINTGTIQFSQD 150  Naumovozyma d...
CCK72036      109 TD-FTGGSLVNTGHIVV-DNRNSSAALSMTW-GG-TTIEN--SGEIYFNGANv-NNNGFTLQPs--TTLNNKGLIYFGQD 179  Kazachstania ...
Q6FUW7         85 STfSINGDINNYGTIVL-DNRNSSDAASVSW-TA-KTFNN--YGSMFFNGASavVQNSFVLTGq--TELVNKGLIQFTQQ 157  [Candida] gla...
Q6FQC7         80 TT-LSSGSVSNQGTFVL-DNRNETNGASLSW-SG-SSFTN--TGTMYFWGAGs-PQNSYDFNPs--GNFENKGTMVFHQD 150  [Candida] gla...
XP_003671316   85 IN-IAGSSLNNKGKLIIdNGPIGTASTLIKL----ATLTN--SG--YLRGRLndGSDGLTVT----DSFINTGYIWLGYS 151  Naumovozyma d...
CAR65602      160 DNLV-GTALINsvniGGLlsGSVleaTNDGSICLDSTAYTQLLSIQGDGCMTVMNGGSI-------NSLldiatgVISLD 231  Debaryomyces ...
EEQ40716      155 VSRSgGNAFFG----QTG--QSV---LNEGTICLYQMNFYQRSKVQGTGCYSVGQDSLLiid--qaSTN------PLPSS 217  Clavispora lu...
EEQ41473      157 VSRSgGTSYFG----QNG--QTV---TNDGTICLYQMNMYQHSIVQGTGCYSVGEDSLLlqd--spKDW------PLPST 219  Clavispora lu...
XP_003678549  154 KPGGlPEVVLIa--------NSI---INDGTICLKNAKSRLQAQIDGNGCINVGDNAMFvikerqyGVL---------GN 213  Naumovozyma c...
CCD27441      152 SMGS-NSATLQs--------NSI---VNDGTICLTNMDSTIQSDTSGSGCFDIGENSIYaiqgkdtAIA---------TN 210  Naumovozyma d...
XP_003671892  151 AIGS-SEADLKs--------ESI---TNDGTICLQNMKSIIQSDVNGNGCFDIGVNSMYviqgkdtAIA---------TN 209  Naumovozyma d...
CCK72036      180 ESSGySSA-------VNIkgKTI---TNDGTICLKNVKAYLDASIGGSGCITIGDNTVYaiqstnmGTL---------GP 240  Kazachstania ...
Q6FUW7        158 PTNWdAVGSVSs--------PSL---VNEGTICLKNMKTQTISSISGSGCIVIGENSIYdmlsishGTV---------GS 217  [Candida] gla...
Q6FQC7        151 SKNTdSYANFQg--------SNV---NNDGTICLTNTKSLLKKSIVGNGCITIGENAMMvlqstssGTM---------GS 210  [Candida] gla...
XP_003671316  152 GNVF-GSFTIN----PPN--TGI---QNSGTISFTDSNVTINFPVTGGGCMVGSTSRDTfav-----------ntDYSID 210  Naumovozyma d...
CAR65602      232 NDIYLADGNSNLQIglgsLSVGiDgvidigTAPtYNLYGFG---GG--NELQIlglgaidglsNIPLLGPvldlVLnlvs 306  Debaryomyces ...
EEQ40716      218 QTIYLSTSSSQVSF----GLSM--------PSNtFTIVGWG---NG--NKIGF----------LTL---------V---- 257  Clavispora lu...
EEQ41473      220 QTVYLSTSSSQIRF----GLET--------PPDtIKISGWG---SN--NKIGF----------TGV---------V---- 259  Clavispora lu...
XP_003678549  214 QTLYMSSNTSVVYA----GSAA--------LTDnIHVAGFG---NG--NFLTF----------RTSI------------- 253  Naumovozyma c...
CCD27441      211 QTFYLSSTTSTLYS----EGNS--------LTDnIIVRGFG---NG--NTLTF----------RTSI------------- 250  Naumovozyma d...
XP_003671892  210 QTFYLSSTTSSLYS----ESNA--------LTDnIIVRGFG---NG--NTLTF----------RTSV------------- 249  Naumovozyma d...
CCK72036      241 QTLYMSSSSSIIYV----DTKG--------KTDnIKVAGFG---NG--NFLSF----------GTSI------------- 280  Kazachstania ...
Q6FUW7        218 QMIYLSSTSSELYA----ESDA--------KTDnIVVAGFG---NG--NVITF----------RTSIDPF----R----- 261  [Candida] gla...
Q6FQC7        211 QTLYMTSSSSIIFA----ESDA--------KTDnIIVRGFG---NG--NILTF----------RTSVDPF----R----- 254  [Candida] gla...
XP_003671316  211 QTIYLTSTTTKSIT----ILGSgKyipvirGVDaKTTFQFGrqvRKsnNTKSV--------------------------- 259  Naumovozyma d...
CAR65602      307 glvgnvilgPDISYDSDTQILTVDmnvlpavinaaktlvprlpsgitLL--S-SKYRLNGDYDSTKF---E--------- 371  Debaryomyces ...
EEQ40716      258 ---------LSATISGSVLTVDVG-----------------------FFtfT---FNVGEGYEQ------Qyisvssggf 296  Clavispora lu...
EEQ41473      260 ---------KSATISGNTLTVVVG-----------------------LNtyT---FDVGSGYQQ------Qyisigngys 298  Clavispora lu...
XP_003678549  254 ---------TGWNYDANTGILSVN-----------------------LFifInHQFNIGKGYNPDLFqmrSitnnv---- 297  Naumovozyma c...
CCD27441      251 ---------VSTSYDDTTGILTVN-----------------------LFplItHKYDIGLGYDSSKFeieSvsndi---- 294  Naumovozyma d...
XP_003671892  250 ---------VSSSYDSETGILSVN-----------------------LFpfIyHDYNIGLGYDSSLFqvkSvsnsi---- 293  Naumovozyma d...
CCK72036      281 ---------VSHSYDTKTGVLSFS-----------------------IFifIsHKFNIGTGYTNSLFkqeQisnhi---- 324  Kazachstania ...
Q6FUW7        262 ---------GKWSYDGKTGILTVK-----------------------VWpsMtHIFNIGLGYDSSKFdwkQidnhc---- 305  [Candida] gla...
Q6FQC7        255 ---------GKWSYDGNSGVLTVK-----------------------LWpsIsHAFHIGKGYDKSKFkqkQitnnv---- 298  [Candida] gla...
XP_003671316  260 -----------ISYNTTSGILTT------------------------WNvyGiMKLDIGTGYDATGFisgQvisg----- 299  Naumovozyma d...
CAR65602      372 ----VQGTNIVYNGDVPS--QSVPQACTACTSV 398  Debaryomyces hansenii CBS767
EEQ40716      297 sggiFILAYVSYSQPPPS--ASSPSVCNDCPTI 327  Clavispora lusitaniae ATCC 42720
EEQ41473      299 sggfFVTSYVSYSQPPPS--SSRPSICAVCPSM 329  Clavispora lusitaniae ATCC 42720
XP_003678549  298 -tpdlvNNALVYEGVPPD--ISRPSACAPCQTI 327  Naumovozyma castellii CBS 4309
CCD27441      295 -aadliNNGLYYRGAPPT--SSRPVQCAACQPI 324  Naumovozyma dairenensis CBS 421
XP_003671892  294 -tpdliNNGLAYLGPPPT--SSRPAVCSVCQPI 323  Naumovozyma dairenensis CBS 421
CCK72036      325 -gldlaNNALYYNAPPPD--ASLPSACMPCDKS 354  Kazachstania naganishii CBS 8797
Q6FUW7        306 -tptlvNNAIYYKGPIPDg-ANKPDKCLpcvdh 336  [Candida] glabrata
Q6FQC7        299 -tptlvNNAVYYDGPVPD--TSKPDVCAICpnn 328  [Candida] glabrata
XP_003671316  300 scstCYAPIISYSGIVPTagTSRPSICDiepdr 332  Naumovozyma dairenensis CBS 421
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