Conserved Protein Domain Family
N-SET

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pfam11764: N-SET 
COMPASS (Complex proteins associated with Set1p) component N
The n-SET or N-SET domain is a component of the COMPASS complex, associated with SET1, conserved in yeasts and in other eukaryotes up to humans. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for the silencing of genes close to the telomeres of chromosomes. This domain promotes trimethylation in conjunction with an RRM domain and is necessary for binding of the Spp1 component of COMPASS into the complex.
Statistics
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PSSM-Id: 403078
View PSSM: pfam11764
Aligned: 73 rows
Threshold Bit Score: 133.956
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003668713  771 KKSIDIldFQEVIkDTEDISILQELLDAnetkPTEEMKHAGCISEYAIWKY-RENEKNL-------RLTNEWH--LN--- 837  Naumovozyma d...
Q16RX0       1376 AILYDF--LTRGI-DAEDIQYIKQSYELl---LSDDANSYLLNATHWVDHC-TTERSFVppp--akKRKKDKE--SV--- 1441 yellow fever ...
Q7QKB2         15 GILFDF--LTRGV-DAEDVRYIRQSYDMl---LMDDASSYWLNATHWVDHC-ATDRNFEpa---llAPPPSKRrkKD--- 81   Anopheles gam...
ETN58655     1778 MVLYDF--LTRGI-DTEDTQYIRQSYDLl---LMDDANNYWLNATHWVDHC-ATDRSFEpalhqalGGPSAAK--RRkkd 1848 Anopheles dar...
5_pfamImport    1 GILYKI--WEAGL-DVEDMKHLRHVYEEm---LATPGEMGWVNDTHWVPHP-TTHIPTDddv-tglSPTKRGRrkRRqsk 72  
XP_026690140 1606 RMMYNI--WDRGL-DVEDMKYLRQEYEDm---LANPGTGGWVNDTHWVPHP-ATYFPDEnda--ltTSPDKRNkrKR--- 1673 vase tunicate
XP_007255045 1561 TILYDI--WNDGI-DEEDIKYLKITYDKl---LQQDNVNDWLNDTLWVHHP-TTSGGSL---------PGLKK--KR--- 1619 Mexican tetra
XP_001920852 1969 TILYDI--WNSGL-DQEDMRLLKSTYEKl---LQDDHGTDWLNDTHWVPHT-ITNIPNP----------RRKK--KT--- 2026 zebrafish
XP_008113606 1644 TILYDI--WNSGL-DLEDMKYLRLTYERl---LHEDNSTDWLNDTHWVHHT-ITNIA----------NPKRKR--KS--- 1701 green anole
XP_005921880 1914 TILYDI--WNSGL-DGEDLLFLKKTYEKl---LQDDHSSDWLNDTHWVNHTiTNLP-----------NPRRKK--KN--- 1971 Burton's mout...
XP_003668713  838 --LNev---pfDVELTKGKGSFKAEGFRKIPDNLKACYL-PHRRKLNQPLNTVNQHGSDRPTGNKFTpepsarreesndP 911  Naumovozyma d...
Q16RX0       1442 -----------SDIKQHSTGSARTEGFYKIDPREKAKYK-YHHLKGTAAANHLN-------------------------N 1484 yellow fever ...
Q7QKB2         82 --KGgaggsslADIKLHRTGCARTEGYYKIDPREKAKYK-YHHLKGTVAANHLT-------------------------N 133  Anopheles gam...
ETN58655     1849 kfIDrs----lADIKLHRTGCARTEGYYKIDALEKAKYK-YHHLKGMTTT----AAGTSSGAAANL-------------- 1905 Anopheles dar...
5_pfamImport   73 kdVA-------ADPHAHKTGCARSEGYYKVNDSTKLI---QRRLMYRQADNTPQPRSKSKYSNE---------------S 127 
XP_026690140 1674 --RQark-ddiSDIKPHKTGCARSEGFYKVNDNTKL---------IQRKLMYRQADNTPQPKGRSKY------------A 1729 vase tunicate
XP_007255045 1620 --RE-------DGMRDHVTGCARSEGYYKIDKKDKLKYLiSSRPQFDEPDKDTQ-------------------------G 1665 Mexican tetra
XP_001920852 2027 --AD-------GQLREHVTGCARSEGYYAISRKEKDVYL-----ELDQPVTLRE-------------------------- 2066 zebrafish
XP_008113606 1702 -----------SDLREHQTGCARSEGYYHISKKEKDKYL-DVCPATVQQLDAPDT------------------------- 1744 green anole
XP_005921880 1972 --TD-------GQLREHVTGCARSEGYYAISRKEKDVYL-----DLDLPEQVIREVENVDTS------------------ 2019 Burton's mout...
XP_003668713  912 DASESVSIQeiSSSRDNRASNRRFQQNIEAQRaaiGAESDLLSLNQ 957  Naumovozyma dairenensis CBS 421
Q16RX0       1485 IEIAKAATKmqGLSREARSNQRRLLTAFGA-----STESELLKFNQ 1525 yellow fever mosquito
Q7QKB2        134 LELAKAVAKmqGISREARSNQRRLLNAFGA-----STESELLKFNQ 174  Anopheles gambiae str. PEST
ETN58655     1906 -ELAKAVAKmqGISREARSNQRRLLNAFGA-----STESELLKFNQ 1945 Anopheles darlingi
5_pfamImport  128 SSTSVVANE---KSRETRHMMRRIASEFG------SDASDLLKYNQ 164 
XP_026690140 1730 NESASTSGVatEKSRETRHMMRRIASEFG------SDASDLLKYNQ 1769 vase tunicate
XP_007255045 1666 KSIPAQPHAstRAGSERRSEQRRLLSSF-------SCDSDLLKFNQ 1704 Mexican tetra
XP_001920852 2067 -IGDYDTAGsnRVLSERRSEQRRLLSAIGTPA---VMDSDLLKLNQ 2108 zebrafish
XP_008113606 1745 -------QGtnRILSERRSEQRRLLSAIGSFA---ILDSDLLKLNQ 1780 green anole
XP_005921880 2020 --------GanRVLSERRSEQRRLLTVIGTTA---VMDSDLLKLNQ 2054 Burton's mouthbrooder
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