Conserved Protein Domain Family
Thoc2

?
pfam11732: Thoc2 
Transcription- and export-related complex subunit
The THO/TREX complex is the transcription- and export-related complex associated with spliceosomes that preferentially deal with spliced mRNAs as opposed to unspliced mRNAs. Thoc2 plays a role in RNA polymerase II (RNA pol II)-dependent transcription and is required for the stability of DNA repeats. In humans, the TRE complex is comprised of the exon-junction-associated proteins Aly/REF and UAP56 together with the THO proteins THOC1 (hHpr1/p84), Thoc2 (hRlr1), THOC3 (hTex1), THOC5 (fSAP79), THOC6 (fSAP35), and THOC7 (fSAP24). Although much evidence indicates that the function of the TREX complex as an adaptor between the mRNA and components of the export machinery is conserved among eukaryotes, in Drosophila the majority of mRNAs can be exported from the nucleus independently of the THO complex.
Statistics
?
PSSM-Id: 403051
View PSSM: pfam11732
Aligned: 94 rows
Threshold Bit Score: 75.9782
Threshold Setting Gi: 124462743
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
EEC50030              590 VAKVCHHHPLVVFSTILSQIESYDNLVEVMVDALRFVTPLSLDVLGFCILSRLSGSgdNgfvnRS-RLKEDGVNVSQWLQ 668  Phaeo...
XP_013935006          578 LTRTAFGNPLAVTSTFVNHIESYSSLSDLIVEASKYFGAFVWDSLTFQLCNKLNSN-------RQ-AMQEDGLNYMQWIQ 649  Ogata...
LoveMIT:GQ68_02411T0  655 LAKIALSNPIPCLLVIVQQLESYDNLNELIVDVSKYFNDFTWDVLPFIILIRLTVN-------RP-HYQPDGINISQWLQ 726  Komag...
XP_011274612          657 FSKIAFANPLPSFLVIVTQVESYDNFSDLIVDAARFFTDYAWDVLPFVLLMRLTTR-------RQ-FVQSDGLNDAQWLQ 728  Wicke...
XP_004199106          625 LAKITYTNPLPCFLTVLQQIESYDNLNSLVVETARYFNGYGWDVLPLALLMRLTAS--G----RS-NVQADGLNDRQWIQ 697  Pichi...
ABN65984              623 LAKISFSNPLPCFLTILQQIESYDNLNTLVVETARYFNKYGWDNLTAAILMRLTLA--G----RS-STQDNGMAERQWLQ 695  Schef...
EDK41258              600 LAKISFANPLPCLLTILQQIESYDNLISLVVDTAKYFNQYGWEALTLAILMRLSAS--G----RS-SIQQDGLNERQWIQ 672  Meyer...
Q6CGS6                571 LAKISYANPLPTFTAFVSQVESYDNLSDLVVEAAKYFTDLGWDALPFVIILQLTSS--G----RD-TVQKDGLNDRKWLQ 643  Yarro...
EFC50430              594 V-----SNPIIVCEEYIRKCETYDNQIPLCVDVSQFSPEISHDIMQYCLLNRLLSN-------QSsNIKEDGISIATWLS 661  Naegl...
A0BH94                570 FAKLSHNQPMIVMNVLRRNRLEIPDNNSVIVHTLGLATPLSLDILQFIMIQWLCDF--N----DEsKVRDKDIECRYWFK 643  Param...
EEC50030              669 SL 670  Phaeodactylum tricornutum CCAP 1055/1
XP_013935006          650 NL 651  Ogataea parapolymorpha DL-1
LoveMIT:GQ68_02411T0  727 SL 728  Komagataella phaffii GS115
XP_011274612          729 SL 730  Wickerhamomyces ciferrii
XP_004199106          698 SL 699  Pichia farinosa CBS 7064
ABN65984              696 SL 697  Scheffersomyces stipitis CBS 6054
EDK41258              673 SL 674  Meyerozyma guilliermondii ATCC 6260
Q6CGS6                644 SL 645  Yarrowia lipolytica
EFC50430              662 NL 663  Naegleria gruberi
A0BH94                644 NI 645  Paramecium tetraurelia
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap