4FHM


Conserved Protein Domain Family
Nup160

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pfam11715: Nup160 
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Nucleoporin Nup120/160
Nup120 is conserved from fungi to plants to humans, and is homologous with the Nup160 of vertebrates. The nuclear core complex, or NPC, mediates macromolecular transport across the nuclear envelope. Deletion of the NUP120 gene causes clustering of NPCs at one side of the nuclear envelope, moderate nucleolar fragmentation and slower cell growth. The vertebrate NPC is estimated to contain between 30 and 60 different proteins. most of which are not known. Two important ones in creating the nucleoporin basket are Nup98 and Nup153, and Nup120, in conjunction with Nup 133, interacts with these two and itself plays a role in mRNA export. Nup160, Nup133, Nup96, and Nup107 are all targets of phosphorylation. The phosphorylation sites are clustered mainly at the N-terminal regions of these proteins, which are predicted to be natively disordered. The entire Nup107-160 sub-complex is stable throughout the cell cycle, thus it seems unlikely that phosphorylation affects interactions within the Nup107-160 sub-complex, but rather that it regulates the association of the sub-complex with the NPC and other proteins.
Statistics
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PSSM-Id: 403040
View PSSM: pfam11715
Aligned: 19 rows
Threshold Bit Score: 217.718
Threshold Setting Gi: 144581629
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4FHM_B            27 LWVPAL-ENDSEDDSEaiet------addNE-KLFKKECVAYDAGVYT---SNKSKGSQTLRWSi--FQNRTLT--IFDV 91   Schizosacc...
EAZ63899          22 ITLPLK-YPSQNQEQN-------------TN-ERFHALLAETGAIIDL---SASQSYIDFVSWDl-lADLKTITlsPINS 82   Schefferso...
Q6C9U5            25 VEIDGS-KLITKKVVDerkrk---lesddAE-EVFLRRYVSKEGQMFQ------SSTNGEFSVRf-fDESHIMEvtGVNH 92   Yarrowia l...
KIS72224          32 IAVPTP-QHTGLEDE--------------PE-PINVAHHHAVDARLYFpsySSTDLDGGFALARv-vAGGRELQllWSNL 94   Ustilago m...
Q9C811            28 ISVPSP-SVSSSSIGAnssednecvqlplSE-DYASSSVIGEPSISFV--------------WRinkTSPNALE--LLQL 89   thale cress
jgi:OSTLU_27350   24 VVDVDA-GVRASADDWraskr---hrgegGEtPSDGARGARGGGVVDS-------KTGDVIAWNvggEFGGDVC--VIKS 90   Ostreococc...
Q9Z0W3            28 FTVCDI-GTASAAFGTvk----------ySE-SAGGFYYVESGKLFSI-------TRNRFIHWK---TSGDTLE--LVEE 83   house mouse
Q29M37            23 VTIHTGdTLNSLQDSQn--------------fEISGGHSYKNNNVMYR---------NRFIYWR---TNKSVLE--LGEV 74   Drosophila...
Q9VKJ3            28 VKINTG-TQSTLQDLKtf-------------eTSGGYCYKNTKNVQTR---------NRFIYWR---TYQDVLE--LSEV 79   fruit fly
Q17II0            27 INVSTG-GIHNMLQDVk-----------tSE-QCGGYCFAEREDFRSN----------RFIYWR---TCRDSIF--LSEV 78   yellow fev...
4FHM_B            92 SLNsk----kEPLSKFNVKIH----------------FPSNV---MKDGVAFSFSEHSD---TTIIYAITHARVLYYIRL 145  Schizosacc...
EAZ63899          83 SVKk------LELPLQNIQVT----------------LPHKIvssKSVSITYQSDQSGNedgYIIVDLVDENFLFVTLRF 140  Schefferso...
Q6C9U5            93 DRK-------------SVRIY----------------FPEGL---QNHCTCVTEKDG-----VLYIDSISNSFLLYSVKL 135  Yarrowia l...
KIS72224          95 KEStsaagpsSKVLTKQHSFSaslspklasepartflFPAPL---LPGLGMFVDPSSN----RLYVIAATTTGFLYRLEF 167  Ustilago m...
Q9C811            90 SAK-------SGFPITGLRFV----------------FAQTL---SPFAFVYADEGGDSgrlVYFLYSLTPSGVVYVLKL 143  thale cress
jgi:OSTLU_27350   91 TRG------------WAVRVV----------------TPSAL---APSCACASDGER-----VDVVLATADGAFVVRVRV 134  Ostreococc...
Q9Z0W3            84 SLD-------LNLLNNAVRLK----------------FQNYNi--LPGGVHVSETQN-H---VIILILTNQTVHRLILPH 134  house mouse
Q29M37            75 SLD-------ISLVRNQLRMR----------------FNEST----VLNVSLTEQPQ-A---ITLLVVTVSSVHRYVFPL 123  Drosophila...
Q9VKJ3            80 SLD-------ISLQRNHLRLR----------------FTDSA----VLNVSLTEQGTS----VTLLVVTVSSVHRYVFPL 128  fruit fly
Q17II0            79 SMN-------LNLTKNNLKIG----------------FDESPi--LSVDISGNQMQ------VFILIVTVTSVHRIVLRH 127  yellow fev...
4FHM_B           146 S-KTWFQ---------LPDARLDD--DW--CLCYRPISF-LNQKPDLM-----------AAISTSEICVSFFNGGLTKII 199  Schizosacc...
EAZ63899         141 AlSDFIVan------nSSKFSLGNfdQW--GHISVPYSFeMRSDPYLV-----------KTVDPLKVIVSLKDGGFLIFK 201  Schefferso...
Q6C9U5           136 P-FALFN---------EDNTEHYDtsRF--FQQQEDYGI-RSRKPLLLk---------sLKGQSNELVLSLCDGGLMKLE 193  Yarrowia l...
KIS72224         168 SaPHLFH---------QAKLASNWssEYriQHIASSESViTASLRGAAnaa------qlYVVDSGLALVTCADGTIIKLS 232  Ustilago m...
Q9C811           144 SnTLAYK-----------SGSVFPldHL--IHLDVRPYLnESRVTS-------------VAASPGFIFLGRSDGCV---- 193  thale cress
jgi:OSTLU_27350  135 R----------------LDGDFDDdgSYeaIVGRAPSSMsGVQRIG-------------ACGAAAAILCDASGCAIVRTD 185  Ostreococc...
Q9Z0W3           135 P-SRMYRselv--tesQMQSIFTDigKV--DFRDPCNSQlIPSVPGLSpgsttsaawlsSDGEAL-FALPSASGGIFVLK 208  house mouse
Q29M37           124 KtATVEVgaaagpddlQSQSIFYDvtEK----IDEPSAYfLTDGLGMPtvaa---sfmsKHAQVAHFAVAYPNKLLHHVM 196  Drosophila...
Q9VKJ3           129 K-VAGQEggaaspedlLSQSIFYDvnDK----INDPSTYyVTDGFGTMpnaav--syltQDSQSAYFAVAYQSKLLLHVM 201  fruit fly
Q17II0           128 PkVSSVNpd------gTPESILANisRE--QICDASSFYvISNDIANAaayr----veyDTGDSEAFFAVSTVSALFLFQ 195  yellow fev...
4FHM_B           200 Lnp------kdASHYEQHIDDSSYLFSLKKYLS--LQAFkaDYRSPNTIISMIFLS------TYNVLVMLSLDYKLKVLD 265  Schizosacc...
EAZ63899         202 Rsa------ilEDVEVGTFSEASSILPFTFLSGifKKDP--RQEVVLEGISSNTIVdvi-qiDSNTIASLTVRKVLKLWS 272  Schefferso...
Q6C9U5           194 Rqe------knGLFLTSLFSDPSYLTSLKDRFFs------kDKIASMPHLSIHAIIsm--tnFENHLLTVSVNQTLKKWD 259  Yarrowia l...
KIS72224         233 RsasgskdnndGAWKETVLRPTSFLSGVSRFFGr-SNAIseSESSPSFALSLDVYPge---vGNTMAFAASRDRKLRVWN 308  Ustilago m...
Q9C811           194 ----------------SCFQPIVYFQKSSGFHQelRDDTgfGRLGTVVAAVQDLFIse--vhGRNYLCVLHADGALRVWD 255  thale cress
jgi:OSTLU_27350  186 R-----------------------LTTVCELQTstLSRVwnTIKGSSGQAVVDVTPrcvrvgAKDLVATLSSDGFVQVWD 242  Ostreococc...
Q9Z0W3           209 Lpp------ydVPGIASVVELKQSSVMQRLLTGw-MPTAirGDHGPS-DRALSLAVhc--veHDAFIFALCQDHKLRMWS 278  house mouse
Q29M37           197 Ncv------dgATVTQEVKEPHLMPRFLYKFAG-----AlrRAESVD--AANDMSFse--idGKTYLLVVYRSNELRLWS 261  Drosophila...
Q9VKJ3           202 Kcs------tgHTITHEIKEPKLMPWFLSNLKG--------ALTGRSETLEAATSMafseigGEIFILVLYRNNELRLWS 267  fruit fly
Q17II0           196 Mg---------HHGGVKMTELKHNQLISRFFSN--LTDGwrRKNANAPDQIVSLMFdq--lnGQSVLYAFYRNNVARIWS 262  yellow fev...
4FHM_B           266 LSTNQCVET-IELSqt------------iLPLQSFPYLTSDHTTNSFIALY-----------------------Y---PD 306  Schizosacc...
EAZ63899         273 TDNLVPTSTpIELT---------------EINDSSSWLTSVPAKYFQVISSktgqs-------------ylslyYstnSA 324  Schefferso...
Q6C9U5           260 LNTLTGTEIkFDSD----------------------KSKLDTEPVTRVCASgeff----------------itfC----- 296  Yarrowia l...
KIS72224         309 LLTDSCIRT-IDLPlqmdspvsnetrlviATDESSSATEGSDTLAYFSSVSrpfvkvfapsrddrdghalyvlvYvpaSP 387  Ustilago m...
Q9C811           256 ILTYSRVLC-QSIAakn----------leGVMCVRLWLGKADYDSGIIPLAv---------------------lY---RK 300  thale cress
jgi:OSTLU_27350  243 VTNAIHASQaRTTDgslk--------patAKVSRVCGSHLPPAPGTKTPAPdrvat------------------sfacAP 296  Ostreococc...
Q9Z0W3           279 YKDQMCLMV-ADMLe-------------yVPVNKDLRLTAGTGHKLRLAYSpsmgl-------------ylgiyM---HA 328  house mouse
Q29M37           262 LDTMQAVST-INCC---------------SGGGVGAPTAQGPQTNVIRKIDdrnf----------------cvfL---SH 306  Drosophila...
Q9VKJ3           268 VDNLQTVAS-INCSt-------------eLGQDSAAQ---GPQNSQLRKISdqnf----------------clfL---SH 311  fruit fly
Q17II0           263 TSGSCVGAE-CFLKn-------------yDQKQEGSQTNMVRKSDNLIGVFl---------------------aY----- 302  yellow fev...
4FHM_B           307 NSHGS---FSIYK-LNANAH----SFKLNVVIEKgiipPSLPDDefipw---mlsdFQLISSegsqSKFLLI-------- 367  Schizosacc...
EAZ63899         325 DNSKSryvFKTWK-IRKSDTiv-eLELLDHLTFQ----PELPNI------------LLLSSSaqpsFQNTLWfiqdyqtq 386  Schefferso...
Q6C9U5           297 --GET---IYFWD-----------QNFVQVFS------SKIPDIglws-----lkdMAFRQNe---GQFEVS-------- 338  Yarrowia l...
KIS72224         388 PSGNF---FSLYG-VELEDSkgssGGLGEVTLLWqkrcDAETRGrnve-----lrdVVFTPQgehgDGWVMW-------- 450  Ustilago m...
Q9C811           301 SMNDS---MDVIT-----------VYGLHFSSAEgialSLDSGLqnipleegelrdVRFTSD-------KIW-------- 351  thale cress
jgi:OSTLU_27350  297 SEKGL---TLNVV-VSSRLApv-eADDEAAAATTtietAADAATlafyt--vkhgaLAFGSSiegsKGVARA-------- 361  Ostreococc...
Q9Z0W3           329 PKRGQ---FCVFQlVSTENNryslDHISSLFTSQetl-----------------vdFALTST-------DIW-------- 373  house mouse
Q29M37           307 DEGAE---FVCVQ-IDKNMTdv-gSRDIELIVKHtvvaPDMdl-----------idFNVTLT-------HIW-------- 355  Drosophila...
Q9VKJ3           312 NSRAE---FICVS-IMPDADda---sVINLVQNM----VPAPQTdl--------vdFDATSS-------HIW-------- 357  fruit fly
Q17II0           303 SDCSE---FIILRpTSDD------SGNVSFVKETailaPNydl-----------idFKLSNQ-------SIW-------- 347  yellow fev...
4FHM_B           368 ---------IAWKSNLNTV--------IQKCNLSLDQDESF--------------SCVWsh---sLDSFSLIEKTFFDVP 413  Schizosacc...
EAZ63899         387 lsddsikfhILWKSNTSSV--------LVTLAINFQTGAIE--------------SKKW------SHSQEGKTFEELGPY 438  Schefferso...
Q6C9U5           339 ---------TVWMSGVSHV--------VKKATVNRNG------------------DIQWse---cGTPLRMLPPLTVHDY 380  Yarrowia l...
KIS72224         451 ---------ALWDGGVGPV--------LKYAKVGVEAANADessisirsmaedlsKDDWrt----vSSERIYRPLHGEDF 509  Ustilago m...
Q9C811           352 ---------TLKANELTSYmlcqksstMEAQSYTLQEDYIS--------------EQLFlssrssSHDLLLTTHSLFSSA 408  thale cress
jgi:OSTLU_27350  362 ---------LALTPDS-----------VVAALENFDDDDASsts--------tstLLSWp----lDALHRARDLRCGDVE 409  Ostreococc...
Q9Z0W3           374 ---------ALWHDAENQ---------TIVKYINFEHNV----------------AGQWnp---vFMQPLPEEEIVIRDD 416  house mouse
Q29M37           356 ---------ALWSNVEGD---------FNASTIHYGSNQ----------------AIQWvs----sVLEPPPDRYCLTTE 397  Drosophila...
Q9VKJ3           358 ---------ALWSNAEGD---------FHVSAAYFASNN----------------AIKWvs----aALEPPPDRYCLTME 399  fruit fly
Q17II0           348 ---------ALWCNAEGE---------MQVLTYSLSSEI----------------DSFWlp----iPLESMDDKYTAKLE 389  yellow fev...
4FHM_B           414 TNMSSgdi--------seiWLQHIFAHNT-SIESIQVAL--LSFQnsssqvsknkldKFGALTISELKNAVLSSIVSTIq 482  Schizosacc...
EAZ63899         439 HDSEY--------------YRNKILNSGRyNDLILQTSL--DVFR------------SYKGLDSVDKKSFIRDSTEETI- 489  Schefferso...
Q6C9U5           381 ERAVS-----------------------LySVPLLKAAL--SIFSrh---------gGGGNTISEAISSQLRLYTN---- 422  Yarrowia l...
KIS72224         510 EATLEatkevv---daadiFLDRVLEPGRfSEATLRLAL--STYKevpm-----ssnHPPSTLFASLRDEVASVVASNCq 579  Ustilago m...
Q9C811           409 KDQIMgfi--------ssiFLRRLLCPGIfHNVALRLTL--LDHNknw------tdsEFQSLSLDELTSEILLLVEHEV- 471  thale cress
jgi:OSTLU_27350  410 ANVLAewghagrgngaaveLLRRFGKLNGyTAASVANSLasEIALrglss--elalqNTCDELGLDEAKTASDALVAAA- 486  Ostreococc...
Q9Z0W3           417 QDPREm-------------YLRSLFTPGHfINAALCKAL--QIFCrg--------teRNLDLSWNELKKEITLAVENELq 473  house mouse
Q29M37           398 QGIDPre-----------aYCSYIFHPGRfDRTVITKAL--YMFRrvn------lqfDVRQLSMTVLKEQVCQAVEDEIq 458  Drosophila...
Q9VKJ3           400 QGVDPre-----------tYCSYIFHPGRfDRNVIAKAL--YMFRrvn------lqfDVKQLSMSVLKEQVCQAVEDEIq 460  fruit fly
Q17II0           390 KGTDLkh-----------vYCSRIFHSGRfHNNVIAKTL--SMFNrsf-------tySGATISTAALKRHVCSYIDGELq 449  yellow fev...
4FHM_B           483 iepnsdLTGYDYYEYKRLLYneWERFAKLVAYLDHFGDEILSINF----------DPSNaVTY------INYANKVAFIR 546  Schizosacc...
EAZ63899         490 ------KLASNNDPYETKQN--WYKLETLCAEFKKLGEEDLAISL----------TNQA-TLL------TIQANGLGIFR 544  Schefferso...
Q6C9U5           423 ------HSGPDYTGYAKDQVeaWSKFEGICQELSRQASACIGSSL----------SGA--QIY------ILTGTGVSTIR 478  Yarrowia l...
KIS72224         580 lendprTGGPMYEKLYASRVreWMRFVGLAEQIETAARWPIGLSLpassfdgsrvSSEAnVPL------VISRDTIALPV 653  Ustilago m...
Q9C811           472 ------TAETSISVFHW-----WKNFCTSYLHHWCSNNEPRTLLV------------QSdVIG------LVRNNSVSLFF 522  thale cress
jgi:OSTLU_27350  487 ------GANASIQRVVET----WCRVAPTYAREWSRAHAPMAFLL------------DTdASWssslvlLRAGDALGAIR 544  Ostreococc...
Q9Z0W3           474 gs--vtEYEFSQDEFRTLQQefWCKFYACVLQYQEALSHPLALHL----------NPVTnMVC------LLKKGYLSFLV 535  house mouse
Q29M37           459 ne--fkEFVVSDEEYLEIATrlWDRFYSCCEQYHIKYSEPIGLSI----------LGGMdAAC------LIRRQSFALLR 520  Drosophila...
Q9VKJ3           461 ne--lkDFVVTDEEYLEISTrlWDRFYSCCEQYHIKLSEPTGLAV----------LGGMdAVC------LVRRQSFALLR 522  fruit fly
Q17II0           450 ne--rkLQNITDEEFIDLSSnlWEKFYMCCSQYNFEACQPIGMLI----------LDRMdAFC------LIRKKFISSLR 511  yellow fev...
4FHM_B           547 DPYLIESF 554  Schizosaccharomyces pombe 972h-
EAZ63899         545 PSHYFESF 552  Scheffersomyces stipitis CBS 6054
Q6C9U5           479 PSTELEKL 486  Yarrowia lipolytica
KIS72224         654 NEDEASVI 661  Ustilago maydis 521
Q9C811           523 RLENAEHS 530  thale cress
jgi:OSTLU_27350  545 AGDDVEES 552  Ostreococcus lucimarinus CCE9901
Q9Z0W3           536 PSSLVDHL 543  house mouse
Q29M37           521 PCELWEHI 528  Drosophila pseudoobscura
Q9VKJ3           523 PCEVLEHL 530  fruit fly
Q17II0           512 PCDELEVA 519  yellow fever mosquito
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