Conserved Protein Domain Family
Vma12

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pfam11712: Vma12 
Endoplasmic reticulum-based factor for assembly of V-ATPase
The yeast vacuolar proton-translocating ATPase (V-ATPase) is the best characterized member of the V-ATPase family. A total of thirteen genes are required for encoding the subunits of the enzyme complex itself and an additional three for providing factors necessary for the assembly of the whole. Vma12 is one of these latter, all three of which are localized to the endoplasmic reticulum.
Statistics
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PSSM-Id: 403039
View PSSM: pfam11712
Aligned: 93 rows
Threshold Bit Score: 58.7872
Threshold Setting Gi: 145238180
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
GAA85329      69 SLLRGT--KVYVPPPPKKPEpvstylspthpptlytnkinkpdikkSPE------------------------------- 115 Aspergillus kaw...
EGF83862      71 RLIKGSriEFVCPKPre----------------------------iTPE------------------------------- 91  Batrachochytriu...
ELV12086      78 ELLEGS--EIYLPEVVKPPR--------------------------NPE------------------------------- 98  Chinese tree shrew
Q19259        16 DLVAGSkeKI------------------------------------TPEvsksckefykkdvvsykdlvniktklpdgip 59  Caenorhabditis ...
EEB20463     283 ELMKGS--DVILPKNEVVER--------------------------NPD------------------------------- 303 human body louse
EGK96271     152 ALLAGC--RLKLPENPICKR--------------------------NPE------------------------------- 172 Anopheles gambi...
XP_002013492 149 ELIESS--DLVLPENEMKPR--------------------------NPD------------------------------- 169 Drosophila pers...
XP_008205783  80 QLLEGV--DIILPEPKVTPR--------------------------NPE------------------------------- 100 jewel wasp
EFN73800       6 ELFNDC--DVILPIPKESPR--------------------------NPE------------------------------- 26  Florida carpent...
XP_022623343  69 ELLEDS--SLHLPEVVKPPR--------------------------NPE------------------------------- 89  greater amberjack
GAA85329     116 ----------------------YLALKARLLAAAETDAYNRMTSSfssssffppssrtpastkpsiftsstptlealhnk 173 Aspergillus kaw...
EGF83862      92 ----------------------YIKFMEKVKIKLENKEYEDIVGKmphgksrdalgsi---------------------- 127 Batrachochytriu...
ELV12086      99 ----------------------LVARLEKIKIQLANEEYKRITRNvtcqdpr---------------------------- 128 Chinese tree shrew
Q19259        60 vfvffdrltlrredhtyhasveFRKKTEELRIQQEQDSYKRLIRDvdpvqkygktdhm---------------------- 117 Caenorhabditis ...
EEB20463     304 ----------------------LLKRIEKLKKEQEEREYKAMTQNvnldkkhfpeds----------------------- 338 human body louse
EGK96271     173 ----------------------LEARCQRLRKEQEDREYHRMTKNvdsirkhmpeet----------------------- 207 Anopheles gambi...
XP_002013492 170 ----------------------LEARCERLRAEQHNREYHKMTKNvdaglkhypedt----------------------- 204 Drosophila pers...
XP_008205783 101 ----------------------LEARIKKLQAQQDARDYQAMTKGvdnfrkhipedt----------------------- 135 jewel wasp
EFN73800      27 ----------------------LEARIQKLKAQQNAREYQTMTKNidsmrkflpeds----------------------- 61  Florida carpent...
XP_022623343  90 ----------------------LVARLEKIKAKLANEEYNRITRNvntqeinrngtla---------------------- 125 greater amberjack
GAA85329     174 hnpkndddNgtDPLT--------------PGLVLNIFLSVLITGFSVYWALRSFrspemlvstvarvwrgkgtgqgvSES 239 Aspergillus kaw...
EGF83862     128 ----------------sgdlvelrkvsgqMMSLLNIFISMAAVFTALYIFAERLw---------------------eDQG 170 Batrachochytriu...
ELV12086     129 --hsgtlsDlgKQVFfpgvlskvrsvkalVVTIFNFIVTVVAAFVCTYLGSQYVf---------------------tEMA 185 Chinese tree shrew
Q19259       118 ----------------enfgvemravnrqMISVINVVITVVGSFFFGFSGITYAyph-----------------lnlDLP 164 Caenorhabditis ...
EEB20463     339 ------------------vsyqmnmmnrhLIAVGQLLVSVGAGFAFGFLGVELIvg-------------------nlNFG 381 human body louse
EGK96271     208 ------------------isyqmkqinrhLIAVAQFLFSVAAGFAFGFIGIELLig-------------------qlDFG 250 Anopheles gambi...
XP_002013492 205 ------------------iayqikslnkqIIAVLQFVFSVAAGFTFGFFGVNLMvg-------------------plPFG 247 Drosophila pers...
XP_008205783 136 ------------------iafqmklmnkqLIAVAQFVFSVMAGFAFGFIGVELIvg-------------------nlDFG 178 jewel wasp
EFN73800      62 ------------------iayqmkqinkqLIAVAQFIISVITGFVFGFIGIELMvg-------------------nlDFG 104 Florida carpent...
XP_022623343 126 -----------------dfgrevrsvkavVVTVFNFLVTVVAAFACSYMGSQYLf---------------------tETT 167 greater amberjack
GAA85329     240 VKVLVSLGAAVVVGVAEVMIYAIYLRKVEVAR 271 Aspergillus kawachii IFO 4308
EGF83862     171 FRVLFGLFGALVVGFAEGWFYTRDWLMDEvnt 202 Batrachochytrium dendrobatidis JAM81
ELV12086     186 SRVLAALIVASVVGLAELYVMVRAVEgelgel 217 Chinese tree shrew
Q19259       165 TRFIFGLVPATIVFFCDLYFVVKGMDMGESSE 196 Caenorhabditis elegans
EEB20463     382 IRLLLGIACALIIAVAEFYFLAKHLNEEDKKe 413 human body louse
EGK96271     251 FRLLLGIIIALIIALAEIYFLAKKLNEEyelp 282 Anopheles gambiae str. PEST
XP_002013492 248 FRILLGVIVALIIALAEMYFLAKKLHEYDevl 279 Drosophila persimilis
XP_008205783 179 FRLLLGVICSIVIALAEIYFLAKKLSEDyedt 210 jewel wasp
EFN73800     105 FRLLLGIICALIIALAEIYFLAVKLSETdtts 136 Florida carpenter ant
XP_022623343 168 ARVISAVIAASVVGLAELYVLVRTMEGelgep 199 greater amberjack
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