Conserved Protein Domain Family
Npa1

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pfam11707: Npa1 
Ribosome 60S biogenesis N-terminal
Npa1p is required for ribosome biogenesis and operates in the same functional environment as Rsa3p and Dbp6p during early maturation of 60S ribosomal subunits. The protein partners of Npa1p include eight putative helicases as well as the novel Npa2p factor. Npa1p can also associate with a subset of H/ACA and C/D small nucleolar RNPs (snoRNPs) involved in the chemical modification of residues in the vicinity of the peptidyl transferase centre. The protein has also been referred to as Urb1, and this domain at the N-terminal is one of several conserved regions along the length.
Statistics
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PSSM-Id: 403035
View PSSM: pfam11707
Aligned: 116 rows
Threshold Bit Score: 175.112
Threshold Setting Gi: 326437488
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
GAC73026      120 AASIFSTWELADRQDLPTLLHLPIFCLAQSL---ALLSVHyp-----------------tHTLGSNIIERILSPnepWLA 179  Moesziomyces ...
ESW99448       50 LNALVQAFSYYSTVNDHSGLSQTLQKLVRLI---RLGIRYqe-----------------lHKPCSTLIQDILSTh--NIK 107  Ogataea parap...
EEQ41565       47 lLKTLSNISYFSSVNSIKQVARVSDNLAQVL---DSINFVlndtnpesknlqfklalldqRERLSEFYSDLCKN---HLK 120  Clavispora lu...
XP_001385716   46 LTKLLSNWSYFASINNHNQFIDLSVKLSKITslfLQQsfs------------------lvRPQIIEFYKDILNN---HLK 104  Scheffersomyc...
XP_007372633   51 ITKLLSIWSFYASTNDHTQFTDISIKLSKLT---FQINSSsevl-------------lsqKHILIDTYKDILNN---YLK 111  Spathaspora p...
EMG45579       49 ISKLLSVWSYYSSTNDLSHLIDVSNKISQIT---KQINDYkssf-------------lsqKQILIDTYKEILHN---HIK 109  Candida malto...
CCE43241       47 lgrtLPIWSYYSSVNNHKEFVDITNKLNHVL---RTINEHkdtf-------------lpvRQFIVDFAKDVLIN---YTK 107  Candida parap...
EDK42643       65 LAKLLPIWSYYSSTNNHKEFVDITNKINAII---FRINKAkslassssss-sssspllqhRQSILDTFKDILIN---HIR 137  Lodderomyces ...
CCE86539       47 LDKVVSAWTYYGATNDHTGFNDLTRDMCNFS---RKASSYktee-------------snvKGNIIDFYKEILDH---GLK 107  Millerozyma f...
Q6BK25         47 LLKVLTSWSYYASINDHSQFTDISIKLSKTS---NLIRDYnts---------------dlKPLLVDFYQHILNN---DLK 105  Debaryomyces ...
GAC73026      180 MLHNYISNlggakfasskqrdsrtSKgsDVAALASLILLREVSTfAKGRYAVKLFDSFNWSMKVLPHIFs-mRRRtnrKs 258  Moesziomyces ...
ESW99448      108 IFYRCLNN----------------QK--GGITNPALRLLSASLEfRKGAYVDLFLDNFDLSLKVLPQLLv-pIKS---Em 165  Ogataea parap...
EEQ41565      121 LVYKVYGL----------------RK--PEAVAGVSRLVVALCEyNDQSVFSEFLDSFDFNHTVLPKIFv-pSRD----- 176  Clavispora lu...
XP_001385716  105 VIYRALNN----------------SK--PSLTNPNLRILTNIVQyD-GSCAHEFLNTFDLTLNVLPNLLv-pTKT---El 161  Scheffersomyc...
XP_007372633  112 VIYRALNN----------------VR--PPLTNANIRILNNLINyD-GIIVSEFLNTFDFTLNSLPRLLvpgKEV---Ev 169  Spathaspora p...
EMG45579      110 IIYRALNN----------------LK--PALTNTNLRILNNIISyD-YIIVQEFLDAFDFTLTVLPKLLe-pKKI---Ei 166  Candida malto...
CCE43241      108 ITYRALSS----------------LK--PSSTNPTIRLLDNLINyD-SIIVQEFLNSFDLTLPVLPKLMt-pSKI---Ei 164  Candida parap...
EDK42643      138 ILYRALSS----------------LK--PSSTNPNIRLLDNIVQyD-PIIAMEFLNQFDMALPVLPKLVt-pSKI---Ei 194  Lodderomyces ...
CCE86539      108 FVYRCLAA----------------NK--PSITNPIIRLLKDIVDfD-KSLVTYFLDNFDLGISTLARLLv-pSKA---Dm 164  Millerozyma f...
Q6BK25        106 YVYRGLNS----------------GK--PLLANSMLNILSNLISfD-NGLTNEFLDKFDMSLSTLPKLLv-pSKI---Di 162  Debaryomyces ...
GAC73026      259 kAAKKPSVALDVslrrPDIRTLYILFLLSFLQQSySNTLKIRLLDLgRDFLPAMLKGL-PQDPPDVVQTILLHLHEDLVK 337  Moesziomyces ...
ESW99448      166 eDPSKCKSK-------SSIRSNFILFWVSLCSQA-NPLTRKDLLFNnRKITTNWIKYIaTHDSYDTIRQALNFLDKYIIE 237  Ogataea parap...
EEQ41565      177 -------DFDRKvllaGSMRSSAVDLWLAICSKC-PATFRKALLTN-FKIMNNFWKYV-EMERYDTLNKIIEFLTKYVLD 246  Clavispora lu...
XP_001385716  162 eNKSTKEH--------LSIRYNFIRFWLTLASSV-PHYHRNDLFANhHKIVNNLWKFL-YIDSVATTKYVVEFLDSKILQ 231  Scheffersomyc...
XP_007372633  170 eTKPA-----------LQIRFNFVSFWLDLCSNV-AYFHRSDLLLNhPKIINNLWKFL-NIDSIELIKKIIAFLDEKVLG 236  Spathaspora p...
EMG45579      167 eTKQINDD--------YSIRFNFLKFWYNLCSNV-NYVTRQDLLINnFKLVKNIWKSL-NLDSIKSIKMTLSFIDTSILQ 236  Candida malto...
CCE43241      165 eAGEVNDQ--------YSIRSNFMKLWIDLCSNA-AYYHRLDLLTNhSKIVKNIWKYL-QYDTINSLLNLIQFLNDKLLD 234  Candida parap...
EDK42643      195 eLGEISNDA-------YSIRCNFIKFWINLCSQV-LHVHRLDLLTNhPKIMRNIWKYL-QYDSLQLIHHLINFLDCKVLD 265  Lodderomyces ...
CCE86539      165 eRYAPTKDDPSMt--kEITRANLIDFWFHLNSIV-PGFIRKDLLNThYKIMNNIWKHMhEIDSLATLNIIFNFVDKNILE 241  Millerozyma f...
Q6BK25        163 eKYSQFKDKPDNt--hLLIRYNFIKFWINLNSKV-SSFIRKDLLINnHKIMNNLWKNMfEIDSVPVLLNIFEFIDSKILD 239  Debaryomyces ...
GAC73026      338 DQRIPRSKKVEFWNEWACGCVVQLYPREEEHVLihadTDavenPSVAELAHHFLLSICTNPGFGICYP-DRGWYPRkasa 416  Moesziomyces ...
ESW99448      238 ERSYKKMTKCKIFGDYIPKKLLELY------------GV----EAVRDEVHDFLTKLATDHEVGLVFSdDR--------- 292  Ogataea parap...
EEQ41565      247 EKSFKRSTKCQILNENFLFNFRSLFPLAASENTrledNDedefSDFKSAFTTFMNVLVSDSARGISYPqNE--------- 317  Clavispora lu...
XP_001385716  232 EVNFKRASKCKILNENFMYKIQSVFAKLEQE----------------KWYLDFVYRLATDSKLGLVYPhDSLFTS----- 290  Scheffersomyc...
XP_007372633  237 EVNFKRSEKCKILSENFMHKIHVVFGKTEESF-----------------FIDFMNKLATDSKQGLMFPnDKLWQK----- 294  Spathaspora p...
EMG45579      237 EVNFKRSLKCKILNEGFMYKISNLFTKFNNNTEnh--------deNFTIFIDFLNKLATDNKYGLVFPnDKLWQKD---- 304  Candida malto...
CCE43241      235 ERNFKKAQKCKILNDSFMYKVHFLFNKIKEPF-----------------FLDFMTKVATDFKNGLVFAnDKLWTQN---- 293  Candida parap...
EDK42643      266 EANFKKSQKCKILNDNFMYKVQALFSKVSEPF-----------------LINFMNKLTTDTKYGIIFAnDSFWNKD---- 324  Lodderomyces ...
CCE86539      242 ESTFKKSTKCKILNENFMHKAYDLFRRIENSGNk----------dLLDRYTNLLMKITTDQVNGLSFPtHRIWQE----- 306  Millerozyma f...
Q6BK25        240 ESNFKKSTKCKILNENFIFKIQLIFNRLSSINNd----------eFSRTFISLLTKLSTDFTNGLNYPnFKLWQSS---- 305  Debaryomyces ...
GAC73026      417 rgDTDeaagtgkaggaangldkdsfsfemgstQKAKPTSIsigGSI--YNKVLSGVLRQLAVAEDLRQQELALSILKACP 494  Moesziomyces ...
ESW99448      293 --NTTdt------------------------tGAPVTIGD---HTFkiHNKLIFSLLASCKPWTDVKQLDLIVSVLSAVP 343  Ogataea parap...
EEQ41565      318 --FG-----------------------------SLLTVNN---KSFkiNNKLIYTLLTALKPWESYSQLQYVMEILNHNS 363  Clavispora lu...
XP_001385716  291 --STT---------------------------GVPVHINN---KTFkiNNKLLYTLLTTLKPSESHAELAFVTKILEVNP 338  Scheffersomyc...
XP_007372633  295 --PAS---------------------------GVPVQINN---KTFriANKLLFTLVTTLKPGDSNVELQYMVRVLEANP 342  Spathaspora p...
EMG45579      305 --SNL---------------------------GVAIEVHN---KTFkvANKLLYTLITSLKPHESNAQLQFIIRTLNNCQ 352  Candida malto...
CCE43241      294 --SDV---------------------------GVVVDVNN---KHFkiANKLLYTLLTSLKPTDSNKQLQFIVKVLSCCQ 341  Candida parap...
EDK42643      325 --SNV---------------------------GVEIEINN---KKFkvANKLLYTLLTSLKPTESNQQLQFIVRVLSSNQ 372  Lodderomyces ...
CCE86539      307 --GQS---------------------------GVSITYNN---KKFrvSNKLIMSFLTSMKPWESAPQLRLTTEIVKKNP 354  Millerozyma f...
Q6BK25        306 --TDN---------------------------GIPININN---KTFriNNKLIYTFLTSLKPWETHVQLQLVKNILSANI 353  Debaryomyces ...
GAC73026      495 ELVGPYL--ESscagLSVDPRPSSRWLCN 521  Moesziomyces antarcticus T-34
ESW99448      344 ELVPCYn-yNLgqtiGVHDPKLSALyiae 371  Ogataea parapolymorpha DL-1
EEQ41565      364 ELLPPYMnwIVafsgGYHDPSLTSYWIGH 392  Clavispora lusitaniae ATCC 42720
XP_001385716  339 ELVAPYMnwMVqhggGYLDPSLTSWWMAH 367  Scheffersomyces stipitis CBS 6054
XP_007372633  343 ELIPPYMnwAVqhggGYHEPSLTSWWISH 371  Spathaspora passalidarum NRRL Y-27907
EMG45579      353 ELIPPYMnyLVqhggGYHDPSLTSWWIAY 381  Candida maltosa Xu316
CCE43241      342 ELIPPYMnyLVqhggGYHDPSLTSWWILY 370  Candida parapsilosis
EDK42643      373 ELVAPYMnyLVqhggGYHDPSLTSWWIAH 401  Lodderomyces elongisporus NRRL YB-4239
CCE86539      355 DLIAPYLnwIIqnggGYHDPSLTSWWIGH 383  Millerozyma farinosa CBS 7064
Q6BK25        354 ELVAPYMnwLIqnggGYHDPSLTSWWIGH 382  Debaryomyces hansenii
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