3K6G


Conserved Protein Domain Family
Rap1_C

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pfam11626: Rap1_C 
TRF2-interacting telomeric protein/Rap1 - C terminal domain
This family of proteins represents the C-terminal domain of the protein Rap-1, which plays a distinct role in silencing at the silent mating-type loci and telomeres. The Rap-1 C-terminus adopts an all-helical fold. Rap1 carries out its function by recruiting the Sir3 and Sir4 proteins to chromatin via its C terminal domain. Rap1 is otherwise known as TRF2-interacting protein, as it is one of the six subunit components of the Shelterin complex. Shelterin protects telomere ends from attack by DNA-repair mechanisms. Model doesn't capture Sch. pombe as it cuts this sequence into two.
Statistics
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PSSM-Id: 402980
View PSSM: pfam11626
Aligned: 76 rows
Threshold Bit Score: 47.2387
Threshold Setting Gi: 354548202
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3K6G_A        22 EKFNLDLSTVTQAFLKNSGELE-ATSAFLASGQR--AD------GYP--------------------------------- 59 
XP_002489597 484 TELGFAHRYTEFLFTSCSGDVIfFRPLVEHFLLTgeWElen--------------------------------------- 524 Komagataella ph...
XP_002491351 439 NALGVKDYYLTFLLDVTSGNLKlIVQIISNYLEDntQYl----tNFPg-------------------------------- 482 Komagataella ph...
XP_013932968 532 EKVGLSMGWLTYWFDCSCGHLNlFMAAILNYIRNdeLIl----sNYPg-------------------------------- 575 Ogataea parapol...
EEQ38841     528 ENIGLQRRFTGHIFKVTGADVRyAHKFLVQFLQGidNHiqtedlLFPrnq------------------------------ 577 Clavispora lusi...
EDK39454     440 KATGFEPNFTAHIVMATNGDVAkMQEYVHEFLQRmnTQaiadpyELAqis------------------------------ 489 Meyerozyma guil...
XP_004200889 500 SDIGITDVFTAHILMCTCADIPrILLFINKFLN-----------MLPyvkedeisn--------------------alni 548 Pichia farinosa...
Q6BU78       525 NEIGINDVFTAHLIMAATGDIVnMQVFIDQFLH-----------LIPhlledklyd--------------------glqi 573 Debaryomyces ha...
XP_007374266 491 NKLGLKDPLISHVVYATSADVPlIPTYCQRLFTAlnAArl--epGIPlykqlr--------------------------i 542 Spathaspora pas...
EDK44188     439 GQVGLCDNFISHVIYACSAETPvMLNYITAFVKQllKN------KQRaegrgggegggeggeaeeirkglvnvykylptg 512 Lodderomyces el...
3K6G_A        60 -----IWSRQDDIDLqk-dDEDTREALVKKFGAQNVARRIEFR 96 
XP_002489597 525 --trgIWTGRQDEMLra-sNLDDLHKLIDLHGKERVETRRKAI 564 Komagataella phaffii GS115
XP_002491351 483 -----VFLPRHDIILlaneNKDEIDQLIKYHSLENVEKRRKYL 520 Komagataella phaffii GS115
XP_013932968 576 -----FWTSEHDRMLk---EEDKISDLIKLHGLESVTKRREAL 610 Ogataea parapolymorpha DL-1
EEQ38841     578 ---ngFWIPEYDMSLek-gDLRELQFQSKSS----IAQRRVFL 612 Clavispora lusitaniae ATCC 42720
EDK39454     490 --rngIWTPETDAMLcs-gNPADIKRLQQTHDHDEIKRRGNFL 529 Meyerozyma guilliermondii ATCC 6260
XP_004200889 549 egsngLWTAEYDRLLld-gSDSGMKTIRQVHDEESIYNRKKFL 590 Pichia farinosa CBS 7064
Q6BU78       574 edtdgIWTSKLDNYLls-gSKQDMKKLQAIQSPQSIEARRHFL 615 Debaryomyces hansenii
XP_007374266 543 vgsgdIWSPKHDQML----GTESEHDLQRPHSLDSIMKRKEFL 581 Spathaspora passalidarum NRRL Y-27907
EDK44188     513 telhgIWTDEFDSVLgt-qQESD---LFQYKSGVEIERRFKFL 551 Lodderomyces elongisporus NRRL YB-4239
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