Conserved Protein Domain Family

pfam11601: Shal-type 
Shal-type voltage-gated potassium channels, N-terminal
This family represents the short N-terminal helical domain of Shal-type voltage-gated potassium channels. The domain interacts with Kv channel-interacting proteins to modulate cell surface expression and the function of Kv4 channels. The interaction of the N-terminus of Shal-type protein Kv4.2 and the Kv interacting protein KChiP1 forms a structure which is like the structure between calmodulin and its target peptides when they interact. Interactions of an N terminal alpha helix in Kv4.2 and a C terminal alpha helix in KChIP1 are essential for the modulation of Kv4.2 by KChIPs.
PSSM-Id: 402960
View PSSM: pfam11601
Aligned: 11 rows
Threshold Bit Score: 51.7101
Threshold Setting Gi: 156210644
Created: 21-May-2020
Updated: 7-Aug-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
XP_023180241    3 TGVAAW-LPFARAAAIGWMPVANCPMPiAP 31  southern platyfish
OWR42869        2 ASVAAW-LPFARAAAIGWVPIATHPLP-SP 29  Danaus plexippus plexippus
XP_002119138    3 TAVAAW-LPFARAAAIGWVPVATNNLP--P 29  vase tunicate
EDO31803        3 aDVVAW-LPFARAAAIGWVPLATSPMP-PP 30  starlet sea anemone
ESN98434        2 vSVAAW-LPFVRAAAIGWIPIGRNQLP-RV 29  Helobdella robusta
ESN98791        2 TSVASW-LPFVRASAIGWVPLAQKPIP-PP 29  Helobdella robusta
ESO10915        2 ASVSAW-LPFVRATGIGWVPIARNPIP--P 28  Helobdella robusta
XP_018874468    3 AGLATW-LPFARAAAVGWLPLAQQPLPpAP 31  western lowland gorilla
jgi:Sthe_0868  14 AALATWtFPFNQVAAIGWLTVAILILP-TP 42  Sphaerobacter thermophilus DSM 20745
OZF99154        2 ASVAAW-LPFARAAAIGWVPISRQPMPqAP 30  Caenorhabditis remanei
XP_029017859    3 aGVAAW-LPFARAAAIGWMPVASTPMPvPP 31  Siamese fighting fish
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