Conserved Protein Domain Family
Saw1

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pfam11561: Saw1 
Single strand annealing-weakened 1
This family of yeast proteins is involved in single-strand-annealing, or SSA. SSA entails multiple steps: end resection and ssDNA formation; annealing of complementary ssDNAs; removal of 3' single-stranded non-homologous tails; gap fill-in synthesis; and ligation. Saw1 in combination with Slx4 catalyzes the 3' non-homologous tail removal during recombination. Saw1 interacts physically with Rad1/Rad10, Msh2/Msh3, and Rad52 proteins, and works by targeting Rad1/Rad10 to Rad52-coated recombination intermediates.
Statistics
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PSSM-Id: 371605
View PSSM: pfam11561
Aligned: 17 rows
Threshold Bit Score: 135.926
Threshold Setting Gi: 149245257
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003683451   1 MAPSVATVKVAEDTVLPLRIFVNRKQLL------QKSSNESIFHTPLLSNNSIVYI----KSPTVKI-----HLSNNDMR 65  Torulaspora del...
CCE65395       1 MPCTIATLTVANNVLLPLRIHVNRKQLLqniansSSDEKDPIFEAPLLANNSIIQL----KAPLTRI-----YLSNKDLT 71  Tetrapisispora ...
CCK70228       1 MAISVATVALDERTTLPLRVFVNRRKLA------SNVKESTLFETPLLSNNSLVSL----KSPKTAI-----YLSNTDME 65  Kazachstania na...
CCF60417       1 MVLNVATVKISDNMVLPLRIFINRKRIL------ENNSSKTIFEAPLLSNNSIVSL----KSPNVRL-----YLSEYDMR 65  Kazachstania af...
XP_001642568   1 MTLSIARIKISDNIILPLRVFINRKQLL------YNITNEPIIQAPLLSNNSIVCL----KSPNTRI-----FVSNNDLE 65  Vanderwaltozyma...
Q759C5         1 MSPTHALLQLQPGYVMPVRVFINRREVL------NNAASCSLFEAPILSNSAIVRL----KSPSVRV-----HLSEDDKQ 65  Eremothecium go...
XP_003646676   1 MTPTLAVVKITPKTGLPIRIFINRKEVLsk---hISGSARPIFEAPLLSNNAIVRL----KSPSVRI-----HLSNEDSR 68  Eremothecium cy...
XP_001527152   1 MAPQITFVAITDTLSLPLKIFTKKTV--------TKLTKDPISSAPLYPHSQATLLsineKSPITLInitesRLSLDEIG 72  Lodderomyces el...
CAR22378       1 M------VQVQSGVVLPIRIFINRQQVAk-----TIQDSSTSFETPLLPNNSIIRL----KSPLIRV-----YLSNTDAR 60  Lachancea therm...
Q6FT09         1 MVQNIAYIKVAKDSILPVRVHINRRQIL------STATEESKVQAPLLSNNTIVCL----KSPLTKI-----YLSNTDLK 65  [Candida] glabrata
XP_003683451  66 DLCSEIITELILIIYEL-APELaVGKTFG---SLRIGQSSDFQDNY-----LSKLlegDDADL--------VKSHIDTIT 128 Torulaspora del...
CCE65395      72 DLCNEIKYDLLFIVYDLtSKEV-MDH------DLRIGKVISFQNDI-----VEKHymkDGEMVnd----miKNCHIESIV 135 Tetrapisispora ...
CCK70228      66 SMCNAIKDDLLMIVYELmGPQV----ALS---KLRVGQEKSFDSIYstteyNHEF----------------IDHHIESIT 122 Kazachstania na...
CCF60417      66 NLCEEIRNDLIFIAYEVsSPEI-LDKIIA---KLRIGNSLPYKENV-----VSKTegeSNKF---------IASHVETIT 127 Kazachstania af...
XP_001642568  66 SLCDEIRDDILLIIYELtSQEV-MNQTIG---KLRVGYNLDFKKSV-----INRFfkdDDTGDy------yIDSNILMVT 130 Vanderwaltozyma...
Q759C5        66 SLLAELRDDLLYIIYELgSPGA--EETLR---KFKIGGLADFRDIVr----------aAEQGDrpeqpipgLDLHTMTFE 130 Eremothecium go...
XP_003646676  69 DLCNELRDELLFIVHEFgSETI-QNELLK---KLKVGSAMDFQELMqvvkgNAGLqrnASRNDdnp--lagLEFHTTIIE 142 Eremothecium cy...
XP_001527152  73 DLVSSIKKRVKAILYDMaTSDTpKEQSLSknkKPKLNQQLGLSLGV-------------------------LTSHRFTVD 127 Lodderomyces el...
CAR22378      61 DLCNDIKKEILLIIYELtSKDV-HDTVTG---KLKIGNCVDIKEAFgktraFSFLydsDP-----------DRCNLTTLE 125 Lachancea therm...
Q6FT09        66 NLVTEMEDDIILILYELsSPAM-KQNIFS---KIRVGQVYDFDEDT-----LKKFpqsIQGSL--------KESNLTSLK 128 [Candida] glabrata
XP_003683451 129 R---------VAKFKYKL----------HYKGNWELEIYI------------------NSVKRLADIRSFLLFK------ 165 Torulaspora del...
CCE65395     136 R---------ISKFKLKI----------SYKHNWELSIFI------------------KSLKQLTEIRNYLLFKnfpthf 178 Tetrapisispora ...
CCK70228     123 R---------LGKFKYKL----------WYKNNWELEIFL------------------NNTLKLSRIRRYMLFRd----- 160 Kazachstania na...
CCF60417     128 R---------VSKFKYKL----------HFKKNWELDIFI------------------NDVRKLSQLRHYLIFS------ 164 Kazachstania af...
XP_001642568 131 R---------VSKLKYKF----------RFKKNWEVDIFI------------------NNIKKLSDLRDYLLFRh----- 168 Vanderwaltozyma...
Q759C5       131 R---------LDKQRFPL----------HFEHNWVVNIIL------------------NDIRKLAVWRRLLLCDia---- 169 Eremothecium go...
XP_003646676 143 R---------IDKNKFTL----------LFKHNWEANIII------------------CDIKRLVKWRKLLCW------- 178 Eremothecium cy...
XP_001527152 128 GynvvipmdvIYQVRYKLraieyedakkYLKRDTGMELCIkrgvvdidevesgkevedSDVEELEQVQNLE--------- 198 Lodderomyces el...
CAR22378     126 R---------IGKHQYKL----------HYDKNWELDIFI------------------TDLRKLARIRSVLLARmsw--- 165 Lachancea therm...
Q6FT09       129 R---------VGKMKYKL----------TYRKNWDVDIFI------------------SNINKLETIRTYLIFKd----- 166 [Candida] glabrata
XP_003683451 166 -----EQGLQHLIRTMPSKRKIL------LTET-------------VSIEKPKILQEVDDN------------------- 202 Torulaspora del...
CCE65395     179 deistEHMVNTGMVSVKNNKRIL------LTTVq-----------eQAPENPVILLEGSDN------------------- 222 Tetrapisispora ...
CCK70228     161 -----SILHNAVNEGIHDKKQLL------LMRQ-------------DSVDISKVPTENDLPl------------------ 198 Kazachstania na...
CCF60417     165 -----KYRSILPPLIVRPDRRLL------LVEHs------------ASSRKPNILIEREED------------------- 202 Kazachstania af...
XP_001642568 169 ----nPNQMSSPSIPINSVKKVL------IMEPddyl------nieTGKDQTMILQEDENDs------------------ 214 Vanderwaltozyma...
Q759C5       170 ---piGVPAAAAPAPMPAGAPYV------LLREr------------RGRVSPQGMLQEDAP------------------- 209 Eremothecium go...
XP_003646676 179 ------------TAFVSNVSGIP------LLSSqesphiivrgaveTTEPAAEILQESDEEdsssrl------------- 227 Eremothecium cy...
XP_001527152 199 ---------------ENSNEDMV------TLTKnkdeaqsetqlnnEANDVEIIDEAATDDtdqlenksnvqvhsprtrd 257 Lodderomyces el...
CAR22378     166 --qgsVFPGAAIPVGDLSGTRILrrcreeIMSKk------------SPTDEPSILLESDDEgalldtaa----------- 220 Lachancea therm...
Q6FT09       167 -----QYPQWNEYPCLQKQQSLL------VMGQkl---------seSTNQDPIILQEEEELn------------------ 208 [Candida] glabrata
XP_003683451 203 --------------------------DISLEEIASSADQKPDLTFKY-----KPVINLGDCIDIHIL 238 Torulaspora delbrueckii
CCE65395     223 --------------------------ESGFIHEHITEDTKPTINYKY-----QPSITLPECIEIHVL 258 Tetrapisispora phaffii CBS 4417
CCK70228     199 --------------------------EDLPLEDLPSEDIKPEVNFRY-----KRMVNLVPCIDIHVL 234 Kazachstania naganishii CBS ...
CCF60417     203 ---------------------------EEDPFAMQPAEEKPEIKFKY-----KPVLNVMSCIDIHVL 237 Kazachstania africana CBS 2517
XP_001642568 215 --------------------------GIIDQQSSQDDDSKPIIHYRY-----KPTLNLAELIDIHVL 250 Vanderwaltozyma polyspora DS...
Q759C5       210 --------------------------EGVPREGDLNVEQKPVLDYRY-----KSVTNLGPGIEIHVL 245 Eremothecium gossypii
XP_003646676 228 ---------------------ilvndDLANRQDLGDGEQKPVVEYNY-----EPLINLGSGIDVHVL 268 Eremothecium cymbalariae DBV...
XP_001527152 258 vevevklekevnssiindkdktnkkqNRASQINRVKDEKKLKMHQNYrlssrQIVGDFASCIKVYVN 324 Lodderomyces elongisporus NR...
CAR22378     221 ------------------vdsststtTRPLKEADLDEDKKPAFKFIH-----SPMVNLGNCIDIHVL 264 Lachancea thermotolerans CBS...
Q6FT09       209 -------------------------lNYEQSAEDQPNNEKPEIAFTY-----EPQLSLIQCLDLYIL 245 [Candida] glabrata
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